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    rsmC 16S rRNA m(2)G1207 methyltransferase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948892, updated on 17-Dec-2024

    Summary

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    Official Symbol
    rsmC
    Official Full Name
    16S rRNA m(2)G1207 methyltransferase
    Primary source
    ECOCYC:G7950
    Locus tag
    b4371
    See related
    ASAP:ABE-0014336
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK4362; yjjT
    Summary
    RsmC is the methyltransferase responsible for methylation of 16S rRNA at the N2 position of the G1207 nucleotide. [More information is available at EcoCyc: G7950].
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    Genomic context

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    Sequence:
    NC_000913.3 (4606669..4607700, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene tRNA-Leu Neighboring gene tRNA-Leu Neighboring gene DNA polymerase III subunit psi Neighboring gene protein N-acetyltransferase RimI Neighboring gene pyrimidine 5'-nucleotidase YjjG

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ribosomal RNA Methyltransferase RsmC Moonlights as an RNA Chaperone. Gc K, et al. Chembiochem, 2020 Jul 1. PMID 31972066
    2. Functional specialization of domains tandemly duplicated within 16S rRNA methyltransferase RsmC. Sunita S, et al. Nucleic Acids Res, 2007. PMID 17576679, Free PMC Article
    3. YfiF, an unknown protein, affects initiation timing of chromosome replication in Escherichia coli. GeZi G, et al. J Basic Microbiol, 2021 Oct. PMID 34486756
    4. Phylogenomic analysis of 16S rRNA:(guanine-N2) methyltransferases suggests new family members and reveals highly conserved motifs and a domain structure similar to other nucleic acid amino-methyltransferases. Bujnicki JM. FASEB J, 2000 Nov. PMID 11053259
    5. RNA:(guanine-N2) methyltransferases RsmC/RsmD and their homologs revisited--bioinformatic analysis and prediction of the active site based on the uncharacterized Mj0882 protein structure. Bujnicki JM, et al. BMC Bioinformatics, 2002 Apr 3. PMID 11929612, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. N-terminus verified by Edman degradation on mature peptide
      Title: Purification, cloning, and characterization of the 16 S RNA m2G1207 methyltransferase from Escherichia coli.
    2. The crystal structure of E. coli RsmC reveals two homologous domains tandemly duplicated within a single polypeptide.
      Title: Functional specialization of domains tandemly duplicated within 16S rRNA methyltransferase RsmC.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables 16S rRNA (guanine(1207)-N(2))-methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 16S rRNA (guanine(1207)-N(2))-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables N-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA folding chaperone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables S-adenosylmethionine-dependent methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables rRNA (guanine-N2-)-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables rRNA (guanine-N2-)-methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables rRNA (guanine-N2-)-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA folding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in rRNA base methylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in rRNA base methylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in rRNA methylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in rRNA methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IC
    Inferred by Curator
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    16S rRNA m(2)G1207 methyltransferase
    NP_418788.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      4606669..4607700 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418788.1 16S rRNA m(2)G1207 methyltransferase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418788.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A403CU42
      Conserved Domains (1) summary
      PRK09489
      Location:1 → 342
      rsmC; 16S rRNA (guanine(1207)-N(2))-methyltransferase RsmC
    Nucleotide Protein
    Heading Accession and Version

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