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    speD S-adenosylmethionine decarboxylase proenzyme [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947719, updated on 17-Dec-2024

    Summary

    Official Symbol
    speD
    Official Full Name
    S-adenosylmethionine decarboxylase proenzyme
    Primary source
    ECOCYC:EG10962
    Locus tag
    b0120
    See related
    ASAP:ABE-0000416
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0119
    Summary
    Paraquat toxicity observed in cells deficient in spermidine. [More information is available at EcoGene: EG10962]. Adenosylmethionine decarboxylase is first synthesized as a proenzyme which is cleaved post-translationally into two smaller polypeptides. [More information is available at EcoCyc: EG10962].
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    Genomic context

    Sequence:
    NC_000913.3 (134788..135582, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene AcnB Neighboring gene PF06062 family protein YacL Neighboring gene spermidine synthase Neighboring gene putative lipoprotein YacC

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables adenosylmethionine decarboxylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables adenosylmethionine decarboxylase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables adenosylmethionine decarboxylase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables carboxy-lyase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables magnesium ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within self proteolysis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in spermidine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in spermidine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within spermidine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    S-adenosylmethionine decarboxylase proenzyme
    NP_414662.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      134788..135582 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_414662.1 S-adenosylmethionine decarboxylase proenzyme [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_414662.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A7A6TY20
      Conserved Domains (1) summary
      PRK05462
      Location:1264
      PRK05462; adenosylmethionine decarboxylase