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    acnA aconitate hydratase 1 [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946724, updated on 3-Dec-2024

    Summary

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    Official Symbol
    acnA
    Official Full Name
    aconitate hydratase 1
    Primary source
    ECOCYC:EG11325
    Locus tag
    b1276
    See related
    ASAP:ABE-0004283
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    acn; ECK1271
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    Genomic context

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    Sequence:
    NC_000913.3 (1335831..1338506)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein YciX Neighboring gene protein YmiC Neighboring gene GTP cyclohydrolase 2 Neighboring gene phosphatidylglycerophosphatase B

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Inactivation-reactivation of aconitase in Escherichia coli. A sensitive measure of superoxide radical. Gardner PR, et al. J Biol Chem, 1992 May 5. PMID 1315737
    2. Superoxide-driven aconitase FE-S center cycling. Gardner PR. Biosci Rep, 1997 Feb. PMID 9171919
    3. Quantitative and kinetic study of oxidative stress regulons using green fluorescent protein. Lu C, et al. Biotechnol Bioeng, 2005 Mar 5. PMID 15672380
    4. The aconitase of Escherichia coli: purification of the enzyme and molecular cloning and map location of the gene (acn). Prodromou C, et al. J Gen Microbiol, 1991 Nov. PMID 1838390
    5. Superoxide sensitivity of the Escherichia coli aconitase. Gardner PR, et al. J Biol Chem, 1991 Oct 15. PMID 1655783

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The structural state of AcnA by the chemical crosslinking and small-angle X-ray scattering was analyzed.
      Title: Cooperativity of two active sites in bacterial homodimeric aconitases.
    2. N-terminus verified by Edman degradation on mature peptide
      Title: The aconitase of Escherichia coli: purification of the enzyme and molecular cloning and map location of the gene (acn).
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables 4 iron, 4 sulfur cluster binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 4 iron, 4 sulfur cluster binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 4 iron, 4 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aconitate hydratase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables aconitate hydratase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables aconitate hydratase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables iron-responsive element binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA 3'-UTR binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within anaerobic respiration IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in citrate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within glyoxylate cycle NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within response to oxidative stress IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in tricarboxylic acid cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tricarboxylic acid cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within tricarboxylic acid cycle NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    aconitate hydratase 1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1335831..1338506
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415792.1 aconitate hydratase 1 [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415792.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A6M9WRD6
      Conserved Domains (1) summary
      PRK09277
      Location:1 → 891
      PRK09277; aconitate hydratase AcnA
    Nucleotide Protein
    Heading Accession and Version

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