U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    rseB anti-sigma factor stabilizing protein RseB [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947054, updated on 3-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    rseB
    Official Full Name
    anti-sigma factor stabilizing protein RseB
    Primary source
    ECOCYC:G7348
    Locus tag
    b2571
    See related
    ASAP:ABE-0008459
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2569
    Summary
    SignalP predicts cleavage of first 23 aa. [More information is available at EcoGene: EG13177]. RseB interacts with RseA, the anti-sigma factor that inhibits sigma E . [More information is available at EcoCyc: G7348].
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Sequence:
    NC_000913.3 (2707798..2708754, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene signal peptidase I Neighboring gene 30S ribosomal subunit biogenesis factor LepA Neighboring gene protein RseC Neighboring gene anti-sigma-E factor RseA Neighboring gene RNA polymerase sigma factor RpoE Neighboring gene rpoE leader peptide Neighboring gene L-aspartate oxidase Neighboring gene tRNA m(6)A37 methyltransferase

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The structure of RseB: a sensor in periplasmic stress response of E. coli. Wollmann P, et al. J Mol Biol, 2007 Sep 28. PMID 17692869
    2. Expression, crystallization and preliminary X-ray analysis of the periplasmic stress sensory protein RseB from Escherichia coli. Wollmann P, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2006 Sep 1. PMID 16946473, Free PMC Article
    3. Recognition of β-strand motifs by RseB is required for σ(E) activity in Escherichia coli. Kulp A, et al. J Bacteriol, 2011 Nov. PMID 21908666, Free PMC Article
    4. Structural basis for the negative regulation of bacterial stress response by RseB. Kim DY, et al. Protein Sci, 2010 Jun. PMID 20512978, Free PMC Article
    5. Two stress sensor proteins for the expression of sigmaE regulon: DegS and RseB. Kim DY. J Microbiol, 2015 May. PMID 25935301

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. DegS and RseB are proposed to be stress sensor proteins for sigmaE signal transduction [review]
      Title: Two stress sensor proteins for the expression of sigmaE regulon: DegS and RseB.
    2. Recognition of beta-strand motifs of sigma(E) by RseB is required for sigma(E) activity.
      Title: Recognition of β-strand motifs by RseB is required for σ(E) activity in Escherichia coli.
    3. Results show RseB binds to RseA and inhibits its sequential cleavage, thereby functioning as a negative modulator of this response.
      Title: Structural basis for the negative regulation of bacterial stress response by RseB.
    4. Results suggest that RseB acts as a sensor of periplasmic stress with a dual functionality: it detects mislocalized lipoproteins and propagates the signal to induce the sigma(E)-response.
      Title: The structure of RseB: a sensor in periplasmic stress response of E. coli.
    5. Although DegS cleavage of RseA is normally activated by binding of the C termini of porins to the PDZ domain of DegS, RseB inhibition is independent of this activation mechanism
      Title: Inhibition of regulated proteolysis by RseB.
    6. Stress sensory protein RseB from E. coli, missing the periplasmic signal sequence, has been cloned, expressed, purified and crystallized.
      Title: Expression, crystallization and preliminary X-ray analysis of the periplasmic stress sensory protein RseB from Escherichia coli.
    7. two RseAs bind to the grooves of the dimeric RseB by conserved residues
      Title: Crystal structure of RseB and a model of its binding mode to RseA.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables antisigma factor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables antisigma factor binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of DNA-templated transcription NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within protein stabilization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of polysaccharide biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in outer membrane-bounded periplasmic space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in outer membrane-bounded periplasmic space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in periplasmic space IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of sigma factor antagonist complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    anti-sigma factor stabilizing protein RseB

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2707798..2708754 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417066.1 anti-sigma factor stabilizing protein RseB [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417066.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A826IYV2
      Conserved Domains (1) summary
      PRK09455
      Location:1 → 318
      rseB; anti-sigma E factor; Provisional
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.