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    dgcT putative diguanylate cyclase DgcT [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945593, updated on 3-Dec-2024

    Summary

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    Official Symbol
    dgcT
    Official Full Name
    putative diguanylate cyclase DgcT
    Primary source
    ECOCYC:G6532
    Locus tag
    b1025
    See related
    ASAP:ABE-0003472
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1015; ycdT
    Summary
    YcdT mRNA is translationally repressed by CsrA (Jonas, 2008). ycdT overexpression causes a 20-fold increase in di-c-GMP and represses motility, but a mutant has little effect (Jonas, 2008). [More information is available at EcoGene: EG13866]. YcdT is a diguanylate cyclase that regulates motility; the effect on motility is probably mediated by the second messenger c-di-GMP . [More information is available at EcoCyc: G6532].
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    Genomic context

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    Sequence:
    NC_000913.3 (1092876..1094234)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene poly-N-acetyl-D-glucosamine synthase subunit PgaC Neighboring gene poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase and beta-1,6 glycoside hydrolase Neighboring gene partially deacetylated poly-beta-1,6-N-acetyl-D-glucosamine export outer membrane porin Neighboring gene IS3 element protein InsF Neighboring gene IS3 element protein InsE Neighboring gene pseudo Neighboring gene uncharacterized protein YcdU

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The diguanylate cyclase YddV controls production of the exopolysaccharide poly-N-acetylglucosamine (PNAG) through regulation of the PNAG biosynthetic pgaABCD operon. Tagliabue L, et al. Microbiology (Reading), 2010 Oct. PMID 20576684
    2. Allosteric activation of exopolysaccharide synthesis through cyclic di-GMP-stimulated protein-protein interaction. Steiner S, et al. EMBO J, 2013 Feb 6. PMID 23202856, Free PMC Article
    3. HmsT, a protein essential for expression of the haemin storage (Hms+) phenotype of Yersinia pestis. Jones HA, et al. Microbiology (Reading), 1999 Aug. PMID 10463178
    4. The RNA binding protein CsrA controls cyclic di-GMP metabolism by directly regulating the expression of GGDEF proteins. Jonas K, et al. Mol Microbiol, 2008 Oct. PMID 18713317, Free PMC Article
    5. C-di-GMP: the dawning of a novel bacterial signalling system. Römling U, et al. Mol Microbiol, 2005 Aug. PMID 16045609

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables diguanylate cyclase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables diguanylate cyclase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables diguanylate cyclase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in c-di-GMP signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within single-species submerged biofilm formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    putative diguanylate cyclase DgcT
    NP_415544.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1092876..1094234
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415544.1 putative diguanylate cyclase DgcT [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415544.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8T6BJW7
      Conserved Domains (2) summary
      pfam00990
      Location:282 → 439
      GGDEF; Diguanylate cyclase, GGDEF domain
      pfam17158
      Location:43 → 275
      MASE4; Membrane-associated sensor, integral membrane domain
    Nucleotide Protein
    Heading Accession and Version

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