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    wcaD colanic acid polymerase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946550, updated on 3-Dec-2024

    Summary

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    Official Symbol
    wcaD
    Official Full Name
    colanic acid polymerase
    Primary source
    ECOCYC:G7101
    Locus tag
    b2056
    See related
    ASAP:ABE-0006809
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2050
    Summary
    The ortholog of WcaD in Escherichia coli O157:H7 is involved in colanic acid synthesis . [More information is available at EcoCyc: G7101].
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    Genomic context

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    Sequence:
    NC_000913.3 (2129661..2130878, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene colanic acid biosynthesis acetyltransferase WcaF Neighboring gene GDP-Fuc:2/3-O-Ac-alpha-L-Fuc-(1->3)-alpha-D-Glc-PP-Und alpha-(1,4)-fucosyltransferase Neighboring gene colanic acid biosynthesis galactosyltransferase WcaC Neighboring gene colanic acid biosynthesis acetyltransferase WcaB Neighboring gene UDP-glucuronate:2-O-Ac-beta-D-Gal-(1->3)-alpha-L-Fuc-(1->4)-2/3-O-Ac-alpha-L-Fuc-(1->3)-beta-D-Glc-PP-Und beta-(1,3)-glucuronosyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Insertion mutagenesis of wca reduces acid and heat tolerance of enterohemorrhagic Escherichia coli O157:H7. Mao Y, et al. J Bacteriol, 2001 Jun. PMID 11371548, Free PMC Article
    2. Biosynthesis and assembly of capsular polysaccharides in Escherichia coli. Whitfield C. Annu Rev Biochem, 2006. PMID 16756484
    3. Development of a biofilm production-deficient Escherichia coli strain as a host for biotechnological applications. Sung BH, et al. Appl Environ Microbiol, 2006 May. PMID 16672475, Free PMC Article
    4. Temporal gene-expression in Escherichia coli K-12 biofilms. Domka J, et al. Environ Microbiol, 2007 Feb. PMID 17222132
    5. Global topology analysis of the Escherichia coli inner membrane proteome. Daley DO, et al. Science, 2005 May 27. PMID 15919996

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Process Evidence Code Pubs
    acts_upstream_of_or_within colanic acid metabolic process IGC
    Inferred from Genomic Context
    more info
    		 PubMed 
    involved_in lipopolysaccharide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in slime layer polysaccharide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    colanic acid polymerase

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2129661..2130878 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416560.1 colanic acid polymerase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416560.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376M7D1, G1UG13
      Conserved Domains (1) summary
      TIGR04010
      Location:1 → 404
      WcaD; putative colanic acid polymerase WcaD
    Nucleotide Protein
    Heading Accession and Version

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