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    nrdI dimanganese-tyrosyl radical cofactor maintenance flavodoxin NrdI [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947158, updated on 3-Dec-2024

    Summary

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    Official Symbol
    nrdI
    Official Full Name
    dimanganese-tyrosyl radical cofactor maintenance flavodoxin NrdI
    Primary source
    ECOCYC:G7402
    Locus tag
    b2674
    See related
    ASAP:ABE-0008804
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2668; ygaO
    Summary
    NrdI is a flavodoxin that mediates maintenance of the diferric-tyrosyl radical cofactor of NrdF, the subunit of the class Ib ribonucleotide reductase . [More information is available at EcoCyc: G7402].
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    Genomic context

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    Sequence:
    NC_000913.3 (2800965..2801375)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene DUF2002 domain-containing protein YgaC Neighboring gene DUF883 domain-containing protein YgaM Neighboring gene glutaredoxin-like protein NrdH Neighboring gene ribonucleoside-diphosphate reductase 2 subunit alpha Neighboring gene ribonucleoside-diphosphate reductase 2 subunit beta Neighboring gene glycine betaine ABC transporter ATP binding subunit ProV Neighboring gene glycine betaine ABC transporter membrane subunit ProW

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structural basis for activation of class Ib ribonucleotide reductase. Boal AK, et al. Science, 2010 Sep 17. PMID 20688982, Free PMC Article
    2. An active dimanganese(III)-tyrosyl radical cofactor in Escherichia coli class Ib ribonucleotide reductase. Cotruvo JA Jr, et al. Biochemistry, 2010 Feb 16. PMID 20070127, Free PMC Article
    3. NrdI, a flavodoxin involved in maintenance of the diferric-tyrosyl radical cofactor in Escherichia coli class Ib ribonucleotide reductase. Cotruvo JA Jr, et al. Proc Natl Acad Sci U S A, 2008 Sep 23. PMID 18799738, Free PMC Article
    4. Expression analysis of the nrdHIEF operon from Escherichia coli. Conditions that trigger the transcript level in vivo. Monje-Casas F, et al. J Biol Chem, 2001 May 25. PMID 11278973
    5. Characterization of Escherichia coli NrdH. A glutaredoxin-like protein with a thioredoxin-like activity profile. Jordan A, et al. J Biol Chem, 1997 Jul 18. PMID 9218434

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables FMN binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables FMN binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables FMN binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein modification process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    dimanganese-tyrosyl radical cofactor maintenance flavodoxin NrdI

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2800965..2801375
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417160.1 dimanganese-tyrosyl radical cofactor maintenance flavodoxin NrdI [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417160.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A2X1MQP8
      Conserved Domains (1) summary
      PRK03600
      Location:1 → 134
      nrdI; class Ib ribonucleoside-diphosphate reductase assembly flavoprotein NrdI
    Nucleotide Protein
    Heading Accession and Version

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