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    PHF21A PHD finger protein 21A [ Homo sapiens (human) ]

    Gene ID: 51317, updated on 10-Dec-2024

    Summary

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    Official Symbol
    PHF21Aprovided by HGNC
    Official Full Name
    PHD finger protein 21Aprovided by HGNC
    Primary source
    HGNC:HGNC:24156
    See related
    Ensembl:ENSG00000135365 MIM:608325; AllianceGenome:HGNC:24156
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BHC80; NEDMS; BM-006; IDDBCS
    Summary
    The PHF21A gene encodes BHC80, a component of a BRAF35 (MIM 605535)/histone deacetylase (HDAC; see MIM 601241) complex (BHC) that mediates repression of neuron-specific genes through the cis-regulatory element known as repressor element-1 (RE1) or neural restrictive silencer (NRS) (Hakimi et al., 2002 [PubMed 12032298]).[supplied by OMIM, Nov 2010]
    Expression
    Ubiquitous expression in testis (RPKM 7.2), ovary (RPKM 5.9) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See PHF21A in Genome Data Viewer
    Location:
    11p11.2
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (45929319..46121454, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (46085233..46277451, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (45950870..46143005, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:45938484-45939236 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3292 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4673 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4674 Neighboring gene peroxisomal biogenesis factor 16 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:45956286-45957284 Neighboring gene LARGE xylosyl- and glucuronyltransferase 2 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:45975728-45975893 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:45986871-45987068 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:46003193-46004090 Neighboring gene Sharpr-MPRA regulatory region 8215 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:46015337-46015518 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:46015959-46016504 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr11:46022272-46022894 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr11:46033641-46034224 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:46141064-46141221 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3293 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3294 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3295 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3296 Neighboring gene uncharacterized LOC105376661 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:46164759-46165418 Neighboring gene FBLIM1 pseudogene 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Transcriptome Analysis Revealed Impaired cAMP Responsiveness in PHF21A-Deficient Human Cells. Porter RS, et al. Neuroscience, 2018 Feb 1. PMID 28571721, Free PMC Article
    2. Disruption of PHF21A causes syndromic intellectual disability with craniofacial anomalies, epilepsy, hypotonia, and neurobehavioral problems including autism. Kim HG, et al. Mol Autism, 2019. PMID 31649809, Free PMC Article
    3. A novel de novo variant in the PHF21A causes craniofacial abnormalities, intellectual disability and skeletal manifestations. Mustafa S, et al. Clin Genet, 2023 Jul. PMID 36843358
    4. Potocki-Shaffer syndrome in a child without intellectual disability-The role of PHF21A in cognitive function. McCool C, et al. Am J Med Genet A, 2017 Mar. PMID 28127865
    5. PHF21A Related Disorder: Description of a New Case. Butera A, et al. Int J Mol Sci, 2022 Dec 17. PMID 36555772, Free PMC Article

    See all (72) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A novel de novo variant in the PHF21A causes craniofacial abnormalities, intellectual disability and skeletal manifestations.
      Title: A novel de novo variant in the PHF21A causes craniofacial abnormalities, intellectual disability and skeletal manifestations.
    2. PHF21A expression as a biomarker of hepatocellular carcinoma progression and prognosis.
      Title: PHF21A expression as a biomarker of hepatocellular carcinoma progression and prognosis.
    3. RNA Splicing of the BHC80 Gene Contributes to Neuroendocrine Prostate Cancer Progression.
      Title: RNA Splicing of the BHC80 Gene Contributes to Neuroendocrine Prostate Cancer Progression.
    4. PHF21A is involved in autism spectrum disorder and intellectual disability, and its haploinsufficiency causes a diverse neurological phenotype.
      Title: Disruption of PHF21A causes syndromic intellectual disability with craniofacial anomalies, epilepsy, hypotonia, and neurobehavioral problems including autism.
    5. PHF21A truncating mutations were identified in three patients with intellectual disability and craniofacial anomalies.
      Title: De novo truncating variants in PHF21A cause intellectual disability and craniofacial anomalies.
    6. Study analyzed by RNA-Sequencing (RNA-Seq) two patient-derived cell lines with heterozygous loss of PHF21A compared to unaffected individuals and identified 1,885 genes that were commonly misregulated. The patient cells displayed down-regulation of key pathways relevant to learning and memory, including Cyclic Adenosine Monophosphate (cAMP)-signaling pathway genes.
      Title: Transcriptome Analysis Revealed Impaired cAMP Responsiveness in PHF21A-Deficient Human Cells.
    7. this case lends further support that haploinsufficiency of PHF21A contributes to the intellectual disability and craniofacial abnormalities in PSS and that there are other genes in the region which likely contribute to the behavioral phenotype in this syndrome.
      Title: Potocki-Shaffer syndrome in a child without intellectual disability-The role of PHF21A in cognitive function.
    8. we have uncovered evidence that the ID and CFA phenotypes are both caused by haploinsufficiency of a single gene, PHF21A, at 11p11.2.
      Title: Translocations disrupting PHF21A in the Potocki-Shaffer-syndrome region are associated with intellectual disability and craniofacial anomalies.
    9. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    10. the recovery of neurosecretion depends on the reciprocal level of BHC80 and REST, with BHC80 working as a negative modulator of REST repression
      Title: The rest repression of the neurosecretory phenotype is negatively modulated by BHC80, a protein of the BRAF/HDAC complex.
    Submit: New GeneRIF Correction See all GeneRIFs (11)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Intellectual developmental disorder with behavioral abnormalities and craniofacial dysmorphism with or without seizures
    MedGen: C5231476 OMIM: 618725 GeneReviews: Not available
    		not available

    Copy number response

    Description
    Copy number response
    Haploinsufficency

    Sufficient evidence for dosage pathogenicity (Last evaluated 2023-09-21)

    ClinGen Genome Curation PagePubMed
    Triplosensitivity

    No evidence available (Last evaluated 2023-09-21)

    ClinGen Genome Curation Page

    EBI GWAS Catalog

    Description
    Nine loci for ocular axial length identified through genome-wide association studies, including shared loci with refractive error.
    EBI GWAS Catalog
    Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
    EBI GWAS Catalog
    Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA1696

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of DNA repair complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of histone deacetylase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of histone deacetylase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    PHD finger protein 21A
    Names
    BHC80a
    BRAF35-HDAC complex protein BHC80
    BRAF35/HDAC2 complex (80 kDa)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001101802.3 → NP_001095272.1  PHD finger protein 21A isoform a

      See identical proteins and their annotated locations for NP_001095272.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform a.
      Source sequence(s)
      AC024475, AC068385
      Consensus CDS
      CCDS44578.1
      UniProtKB/Swiss-Prot
      D3DQP5, Q6AWA2, Q96BD5, Q9C0G7, Q9H8V9, Q9HAK6, Q9NZE9
      UniProtKB/TrEMBL
      H0YEK2
      Related
      ENSP00000398824.2, ENST00000418153.6
      Conserved Domains (2) summary
      COG5034
      Location:374 → 536
      TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
      cd15523
      Location:490 → 532
      PHD_PHF21A; PHD finger found in PHD finger protein 21A (PHF21A)

    2. NM_001352025.3 → NP_001338954.1  PHD finger protein 21A isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (c). Variants 3, 4, and 5 all encode isoform c.
      Source sequence(s)
      AC024475, AC068385
      Consensus CDS
      CCDS91465.1
      UniProtKB/TrEMBL
      H0YEK2
      Conserved Domains (2) summary
      COG5034
      Location:375 → 537
      TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
      cd15523
      Location:491 → 533
      PHD_PHF21A; PHD finger found in PHD finger protein 21A (PHF21A)

    3. NM_001352026.3 → NP_001338955.1  PHD finger protein 21A isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4), as well as variants 3 and 5, encodes isoform c.
      Source sequence(s)
      AC024475, AC068385
      Consensus CDS
      CCDS91465.1
      UniProtKB/TrEMBL
      H0YEK2
      Conserved Domains (2) summary
      COG5034
      Location:375 → 537
      TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
      cd15523
      Location:491 → 533
      PHD_PHF21A; PHD finger found in PHD finger protein 21A (PHF21A)

    4. NM_001352027.3 → NP_001338956.1  PHD finger protein 21A isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5), as well as variants 3 and 4, encodes isoform c.
      Source sequence(s)
      AC024475, AC068385
      Consensus CDS
      CCDS91465.1
      UniProtKB/TrEMBL
      H0YEK2
      Related
      ENSP00000502222.1, ENST00000676320.1
      Conserved Domains (2) summary
      COG5034
      Location:375 → 537
      TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
      cd15523
      Location:491 → 533
      PHD_PHF21A; PHD finger found in PHD finger protein 21A (PHF21A)

    5. NM_001352028.1 → NP_001338957.1  PHD finger protein 21A isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6), as well as variants 2 and 7, encodes isoform b.
      Source sequence(s)
      AC024475, AC068385
      Consensus CDS
      CCDS31474.1
      UniProtKB/TrEMBL
      H0YEK2
      Conserved Domains (1) summary
      cd15523
      Location:444 → 486
      PHD_PHF21A; PHD finger found in PHD finger protein 21A (PHF21A)

    6. NM_001352029.1 → NP_001338958.1  PHD finger protein 21A isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7), as well as variants 2 and 6, encodes isoform b.
      Source sequence(s)
      AC024475, AC068385
      Consensus CDS
      CCDS31474.1
      UniProtKB/TrEMBL
      H0YEK2
      Related
      ENSP00000508589.1, ENST00000690620.1
      Conserved Domains (1) summary
      cd15523
      Location:444 → 486
      PHD_PHF21A; PHD finger found in PHD finger protein 21A (PHF21A)

    7. NM_001352030.3 → NP_001338959.1  PHD finger protein 21A isoform 8

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8), as well as variants 9 and 10, encodes isoform d.
      Source sequence(s)
      AC024475, AC068385
      UniProtKB/TrEMBL
      H0YEK2
      Conserved Domains (1) summary
      cd15523
      Location:443 → 485
      PHD_PHF21A; PHD finger found in PHD finger protein 21A (PHF21A)

    8. NM_001352031.3 → NP_001338960.1  PHD finger protein 21A isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (9), as well as variants 8 and 10, encodes isoform d.
      Source sequence(s)
      AC024475, AC068385
      UniProtKB/TrEMBL
      H0YEK2
      Conserved Domains (1) summary
      cd15523
      Location:443 → 485
      PHD_PHF21A; PHD finger found in PHD finger protein 21A (PHF21A)

    9. NM_001352032.3 → NP_001338961.1  PHD finger protein 21A isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (10), as well as variants 8 and 9, encodes isoform d.
      Source sequence(s)
      AC024475, AC068385
      UniProtKB/TrEMBL
      H0YEK2
      Conserved Domains (1) summary
      cd15523
      Location:443 → 485
      PHD_PHF21A; PHD finger found in PHD finger protein 21A (PHF21A)

    10. NM_016621.5 → NP_057705.3  PHD finger protein 21A isoform b

      See identical proteins and their annotated locations for NP_057705.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the mid-coding region, and includes an alternate in-frame exon in the 3' coding region, but lacks a different alternate in-frame exon in the 3' coding region, compared to variant 1. The resulting protein (isoform b) is shorter than isoform a. Variants 2, 6, and 7 all encode the same isoform (b).
      Source sequence(s)
      AB051483, AC024475, AC068385
      Consensus CDS
      CCDS31474.1
      UniProtKB/TrEMBL
      H0YEK2
      Related
      ENSP00000323152.6, ENST00000323180.10
      Conserved Domains (1) summary
      cd15523
      Location:444 → 486
      PHD_PHF21A; PHD finger found in PHD finger protein 21A (PHF21A)

    RNA

    1. NR_147890.3 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC024475, AC068385

    2. NR_165446.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC024475, AC068385

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      45929319..46121454 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047427091.1 → XP_047283047.1  PHD finger protein 21A isoform X8

      UniProtKB/TrEMBL
      H0YEK2

    2. XM_047427108.1 → XP_047283064.1  PHD finger protein 21A isoform X19

      UniProtKB/TrEMBL
      H0YEK2

    3. XM_047427085.1 → XP_047283041.1  PHD finger protein 21A isoform X6

      UniProtKB/TrEMBL
      H0YEK2

    4. XM_047427109.1 → XP_047283065.1  PHD finger protein 21A isoform X18

      UniProtKB/TrEMBL
      H0YEK2

    5. XM_047427105.1 → XP_047283061.1  PHD finger protein 21A isoform X17

      UniProtKB/TrEMBL
      H0YEK2

    6. XM_047427094.1 → XP_047283050.1  PHD finger protein 21A isoform X9

      UniProtKB/TrEMBL
      H0YCM5

    7. XM_047427081.1 → XP_047283037.1  PHD finger protein 21A isoform X2

    8. XM_047427082.1 → XP_047283038.1  PHD finger protein 21A isoform X3

    9. XM_047427098.1 → XP_047283054.1  PHD finger protein 21A isoform X12

      UniProtKB/TrEMBL
      H0YEK2

    10. XM_011520157.3 → XP_011518459.1  PHD finger protein 21A isoform X1

      See identical proteins and their annotated locations for XP_011518459.1

      Conserved Domains (2) summary
      cd15523
      Location:498 → 540
      PHD_PHF21A; PHD finger found in PHD finger protein 21A (PHF21A)
      cl26267
      Location:382 → 544
      ING; Inhibitor of growth proteins N-terminal histone-binding

    11. XM_017017907.2 → XP_016873396.1  PHD finger protein 21A isoform X22

      Conserved Domains (3) summary
      COG5034
      Location:291 → 453
      TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
      cd15523
      Location:407 → 449
      PHD_PHF21A; PHD finger found in PHD finger protein 21A (PHF21A)
      pfam01017
      Location:3 → 62
      STAT_alpha; STAT protein, all-alpha domain

    12. XM_047427090.1 → XP_047283046.1  PHD finger protein 21A isoform X8

      UniProtKB/TrEMBL
      H0YEK2

    13. XM_017017892.2 → XP_016873381.1  PHD finger protein 21A isoform X6

      UniProtKB/TrEMBL
      H0YEK2
      Conserved Domains (2) summary
      COG5034
      Location:374 → 536
      TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
      cd15523
      Location:490 → 532
      PHD_PHF21A; PHD finger found in PHD finger protein 21A (PHF21A)

    14. XM_047427107.1 → XP_047283063.1  PHD finger protein 21A isoform X18

      UniProtKB/TrEMBL
      H0YEK2

    15. XM_017017891.2 → XP_016873380.1  PHD finger protein 21A isoform X7

      UniProtKB/Swiss-Prot
      D3DQP5, Q6AWA2, Q96BD5, Q9C0G7, Q9H8V9, Q9HAK6, Q9NZE9
      UniProtKB/TrEMBL
      H0YEK2
      Conserved Domains (2) summary
      COG5034
      Location:374 → 536
      TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
      cd15523
      Location:490 → 532
      PHD_PHF21A; PHD finger found in PHD finger protein 21A (PHF21A)

    16. XM_047427104.1 → XP_047283060.1  PHD finger protein 21A isoform X17

      UniProtKB/TrEMBL
      H0YEK2

    17. XM_047427092.1 → XP_047283048.1  PHD finger protein 21A isoform X9

      UniProtKB/TrEMBL
      H0YCM5

    18. XM_011520179.4 → XP_011518481.1  PHD finger protein 21A isoform X14

      See identical proteins and their annotated locations for XP_011518481.1

      UniProtKB/TrEMBL
      H0YEK2
      Conserved Domains (1) summary
      cd15523
      Location:444 → 486
      PHD_PHF21A; PHD finger found in PHD finger protein 21A (PHF21A)

    19. XM_017017889.2 → XP_016873378.1  PHD finger protein 21A isoform X2

      Conserved Domains (2) summary
      cd15523
      Location:497 → 539
      PHD_PHF21A; PHD finger found in PHD finger protein 21A (PHF21A)
      cl26267
      Location:381 → 543
      ING; Inhibitor of growth proteins N-terminal histone-binding

    20. XM_011520158.3 → XP_011518460.1  PHD finger protein 21A isoform X1

      See identical proteins and their annotated locations for XP_011518460.1

      Conserved Domains (2) summary
      cd15523
      Location:498 → 540
      PHD_PHF21A; PHD finger found in PHD finger protein 21A (PHF21A)
      cl26267
      Location:382 → 544
      ING; Inhibitor of growth proteins N-terminal histone-binding

    21. XM_047427087.1 → XP_047283043.1  PHD finger protein 21A isoform X6

      UniProtKB/TrEMBL
      H0YEK2

    22. XM_047427102.1 → XP_047283058.1  PHD finger protein 21A isoform X15

      UniProtKB/TrEMBL
      H0YEK2
      Related
      ENSP00000431964.2, ENST00000525676.6

    23. XM_047427110.1 → XP_047283066.1  PHD finger protein 21A isoform X18

      UniProtKB/TrEMBL
      H0YEK2

    24. XM_047427089.1 → XP_047283045.1  PHD finger protein 21A isoform X7

      UniProtKB/Swiss-Prot
      D3DQP5, Q6AWA2, Q96BD5, Q9C0G7, Q9H8V9, Q9HAK6, Q9NZE9
      UniProtKB/TrEMBL
      H0YEK2

    25. XM_005252965.5 → XP_005253022.1  PHD finger protein 21A isoform X5

      See identical proteins and their annotated locations for XP_005253022.1

      UniProtKB/TrEMBL
      H0YEK2
      Conserved Domains (2) summary
      COG5034
      Location:375 → 537
      TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
      cd15523
      Location:491 → 533
      PHD_PHF21A; PHD finger found in PHD finger protein 21A (PHF21A)

    26. XM_047427101.1 → XP_047283057.1  PHD finger protein 21A isoform X14

      UniProtKB/TrEMBL
      H0YEK2

    27. XM_017017887.3 → XP_016873376.1  PHD finger protein 21A isoform X1

      Conserved Domains (2) summary
      cd15523
      Location:498 → 540
      PHD_PHF21A; PHD finger found in PHD finger protein 21A (PHF21A)
      cl26267
      Location:382 → 544
      ING; Inhibitor of growth proteins N-terminal histone-binding

    28. XM_011520175.3 → XP_011518477.1  PHD finger protein 21A isoform X6

      See identical proteins and their annotated locations for XP_011518477.1

      UniProtKB/TrEMBL
      H0YEK2
      Conserved Domains (2) summary
      COG5034
      Location:374 → 536
      TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
      cd15523
      Location:490 → 532
      PHD_PHF21A; PHD finger found in PHD finger protein 21A (PHF21A)

    29. XM_011520174.3 → XP_011518476.1  PHD finger protein 21A isoform X5

      See identical proteins and their annotated locations for XP_011518476.1

      UniProtKB/TrEMBL
      H0YEK2
      Conserved Domains (2) summary
      COG5034
      Location:375 → 537
      TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
      cd15523
      Location:491 → 533
      PHD_PHF21A; PHD finger found in PHD finger protein 21A (PHF21A)

    30. XM_047427093.1 → XP_047283049.1  PHD finger protein 21A isoform X9

      UniProtKB/TrEMBL
      H0YCM5

    31. XM_047427100.1 → XP_047283056.1  PHD finger protein 21A isoform X14

      UniProtKB/TrEMBL
      H0YEK2

    32. XM_047427088.1 → XP_047283044.1  PHD finger protein 21A isoform X6

      UniProtKB/TrEMBL
      H0YEK2

    33. XM_047427084.1 → XP_047283040.1  PHD finger protein 21A isoform X5

      UniProtKB/TrEMBL
      H0YEK2

    34. XM_047427079.1 → XP_047283035.1  PHD finger protein 21A isoform X1

    35. XM_047427086.1 → XP_047283042.1  PHD finger protein 21A isoform X7

      UniProtKB/Swiss-Prot
      D3DQP5, Q6AWA2, Q96BD5, Q9C0G7, Q9H8V9, Q9HAK6, Q9NZE9
      UniProtKB/TrEMBL
      H0YEK2

    36. XM_047427080.1 → XP_047283036.1  PHD finger protein 21A isoform X1

    37. XM_047427103.1 → XP_047283059.1  PHD finger protein 21A isoform X16

      UniProtKB/TrEMBL
      H0YEK2

    38. XM_047427083.1 → XP_047283039.1  PHD finger protein 21A isoform X4

    39. XM_047427097.1 → XP_047283053.1  PHD finger protein 21A isoform X11

      UniProtKB/TrEMBL
      H0YEK2

    40. XM_047427099.1 → XP_047283055.1  PHD finger protein 21A isoform X13

      UniProtKB/TrEMBL
      H0YEK2

    41. XM_047427095.1 → XP_047283051.1  PHD finger protein 21A isoform X10

      UniProtKB/TrEMBL
      H0YEK2

    42. XM_047427113.1 → XP_047283069.1  PHD finger protein 21A isoform X21

      UniProtKB/TrEMBL
      H0YEK2

    43. XM_047427111.1 → XP_047283067.1  PHD finger protein 21A isoform X20

      UniProtKB/TrEMBL
      H0YEK2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      46085233..46277451 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054369083.1 → XP_054225058.1  PHD finger protein 21A isoform X8

      UniProtKB/TrEMBL
      H0YEK2

    2. XM_054369099.1 → XP_054225074.1  PHD finger protein 21A isoform X19

      UniProtKB/TrEMBL
      H0YEK2

    3. XM_054369076.1 → XP_054225051.1  PHD finger protein 21A isoform X6

      UniProtKB/TrEMBL
      H0YEK2

    4. XM_054369100.1 → XP_054225075.1  PHD finger protein 21A isoform X18

      UniProtKB/TrEMBL
      H0YEK2

    5. XM_054369097.1 → XP_054225072.1  PHD finger protein 21A isoform X17

      UniProtKB/TrEMBL
      H0YEK2

    6. XM_054369086.1 → XP_054225061.1  PHD finger protein 21A isoform X9

      UniProtKB/TrEMBL
      H0YCM5

    7. XM_054369068.1 → XP_054225043.1  PHD finger protein 21A isoform X2

    8. XM_054369069.1 → XP_054225044.1  PHD finger protein 21A isoform X3

    9. XM_054369089.1 → XP_054225064.1  PHD finger protein 21A isoform X12

      UniProtKB/TrEMBL
      H0YEK2

    10. XM_054369062.1 → XP_054225037.1  PHD finger protein 21A isoform X1

    11. XM_054369104.1 → XP_054225079.1  PHD finger protein 21A isoform X22

    12. XM_054369082.1 → XP_054225057.1  PHD finger protein 21A isoform X8

      UniProtKB/TrEMBL
      H0YEK2

    13. XM_054369074.1 → XP_054225049.1  PHD finger protein 21A isoform X6

      UniProtKB/TrEMBL
      H0YEK2

    14. XM_054369098.1 → XP_054225073.1  PHD finger protein 21A isoform X18

      UniProtKB/TrEMBL
      H0YEK2

    15. XM_054369075.1 → XP_054225050.1  PHD finger protein 21A isoform X7

      UniProtKB/Swiss-Prot
      D3DQP5, Q6AWA2, Q96BD5, Q9C0G7, Q9H8V9, Q9HAK6, Q9NZE9
      UniProtKB/TrEMBL
      H0YEK2

    16. XM_054369096.1 → XP_054225071.1  PHD finger protein 21A isoform X17

      UniProtKB/TrEMBL
      H0YEK2

    17. XM_054369084.1 → XP_054225059.1  PHD finger protein 21A isoform X9

      UniProtKB/TrEMBL
      H0YCM5

    18. XM_054369091.1 → XP_054225066.1  PHD finger protein 21A isoform X14

      UniProtKB/TrEMBL
      H0YEK2

    19. XM_054369067.1 → XP_054225042.1  PHD finger protein 21A isoform X2

    20. XM_054369064.1 → XP_054225039.1  PHD finger protein 21A isoform X1

    21. XM_054369101.1 → XP_054225076.1  PHD finger protein 21A isoform X18

      UniProtKB/TrEMBL
      H0YEK2

    22. XM_054369094.1 → XP_054225069.1  PHD finger protein 21A isoform X15

      UniProtKB/TrEMBL
      H0YEK2

    23. XM_054369063.1 → XP_054225038.1  PHD finger protein 21A isoform X1

    24. XM_054369065.1 → XP_054225040.1  PHD finger protein 21A isoform X1

    25. XM_054369066.1 → XP_054225041.1  PHD finger protein 21A isoform X1

    26. XM_054369078.1 → XP_054225053.1  PHD finger protein 21A isoform X6

      UniProtKB/TrEMBL
      H0YEK2

    27. XM_054369080.1 → XP_054225055.1  PHD finger protein 21A isoform X7

      UniProtKB/Swiss-Prot
      D3DQP5, Q6AWA2, Q96BD5, Q9C0G7, Q9H8V9, Q9HAK6, Q9NZE9
      UniProtKB/TrEMBL
      H0YEK2

    28. XM_054369093.1 → XP_054225068.1  PHD finger protein 21A isoform X14

      UniProtKB/TrEMBL
      H0YEK2

    29. XM_054369081.1 → XP_054225056.1  PHD finger protein 21A isoform X6

      UniProtKB/TrEMBL
      H0YEK2

    30. XM_054369085.1 → XP_054225060.1  PHD finger protein 21A isoform X9

      UniProtKB/TrEMBL
      H0YCM5

    31. XM_054369092.1 → XP_054225067.1  PHD finger protein 21A isoform X14

      UniProtKB/TrEMBL
      H0YEK2

    32. XM_054369079.1 → XP_054225054.1  PHD finger protein 21A isoform X6

      UniProtKB/TrEMBL
      H0YEK2

    33. XM_054369077.1 → XP_054225052.1  PHD finger protein 21A isoform X7

      UniProtKB/Swiss-Prot
      D3DQP5, Q6AWA2, Q96BD5, Q9C0G7, Q9H8V9, Q9HAK6, Q9NZE9
      UniProtKB/TrEMBL
      H0YEK2

    34. XM_054369073.1 → XP_054225048.1  PHD finger protein 21A isoform X5

      UniProtKB/TrEMBL
      H0YEK2

    35. XM_054369071.1 → XP_054225046.1  PHD finger protein 21A isoform X5

      UniProtKB/TrEMBL
      H0YEK2

    36. XM_054369072.1 → XP_054225047.1  PHD finger protein 21A isoform X5

      UniProtKB/TrEMBL
      H0YEK2

    37. XM_054369095.1 → XP_054225070.1  PHD finger protein 21A isoform X16

      UniProtKB/TrEMBL
      H0YEK2

    38. XM_054369070.1 → XP_054225045.1  PHD finger protein 21A isoform X4

    39. XM_054369088.1 → XP_054225063.1  PHD finger protein 21A isoform X11

      UniProtKB/TrEMBL
      H0YEK2

    40. XM_054369090.1 → XP_054225065.1  PHD finger protein 21A isoform X13

      UniProtKB/TrEMBL
      H0YEK2

    41. XM_054369087.1 → XP_054225062.1  PHD finger protein 21A isoform X10

      UniProtKB/TrEMBL
      H0YEK2

    42. XM_054369103.1 → XP_054225078.1  PHD finger protein 21A isoform X21

      UniProtKB/TrEMBL
      H0YEK2

    43. XM_054369102.1 → XP_054225077.1  PHD finger protein 21A isoform X20

      UniProtKB/TrEMBL
      H0YEK2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96BD5.1 GenPept UniProtKB/Swiss-Prot:Q96BD5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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