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    XPO1 exportin 1 [ Homo sapiens (human) ]

    Gene ID: 7514, updated on 10-Dec-2024

    Summary

    Official Symbol
    XPO1provided by HGNC
    Official Full Name
    exportin 1provided by HGNC
    Primary source
    HGNC:HGNC:12825
    See related
    Ensembl:ENSG00000082898 MIM:602559; AllianceGenome:HGNC:12825
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    emb; CRM1; exp1; CRM-1
    Summary
    This cell-cycle-regulated gene encodes a protein that mediates leucine-rich nuclear export signal (NES)-dependent protein transport. The protein specifically inhibits the nuclear export of Rev and U snRNAs. It is involved in the control of several cellular processes by controlling the localization of cyclin B, MPAK, and MAPKAP kinase 2. This protein also regulates NFAT and AP-1. [provided by RefSeq, Jan 2015]
    Expression
    Ubiquitous expression in testis (RPKM 38.6), lymph node (RPKM 33.8) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See XPO1 in Genome Data Viewer
    Location:
    2p15
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (61477849..61538612, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (61483936..61544825, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (61704984..61765491, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ubiquitin specific peptidase 34 Neighboring gene BNIP3 pseudogene 45 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr2:61504619-61505818 Neighboring gene NANOG hESC enhancer GRCh37_chr2:61607882-61608383 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:61644005-61644197 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:61652307-61652984 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:61652985-61653662 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:61653663-61654340 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:61657175-61657369 Neighboring gene small nucleolar RNA, H/ACA box 70B Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11526 Neighboring gene MPRA-validated peak3715 silencer Neighboring gene Sharpr-MPRA regulatory region 6736 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15830 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:61692432-61692952 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:61692953-61693472 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:61694001-61694500 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11527 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11528 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11529 Neighboring gene MPRA-validated peak3716 silencer Neighboring gene USP34 divergent transcript Neighboring gene MPRA-validated peak3717 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:61743599-61744099 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15831 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15832 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15833 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:61766044-61766833 Neighboring gene proteasome 26S subunit, non-ATPase 12 pseudogene Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:61809253-61809844 Neighboring gene ribosomal protein S29 pseudogene 10

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    HIV-1 requires XPO1 for efficient replication as determined through the use of the XPO1 inhibitor KPT-185 PubMed
    Knockdown of exportin 1 (CRM1 homolog; XPO1) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

    Protein interactions

    Items 1 - 20 of 40
    Protein Gene Interaction Pubs
    Pr55(Gag) gag Human CRM1 exports gag mRNA to the cytoplasm more efficiently than rat CRM1 in rat cells, leading to efficient processing of Gag proteins and particle formation PubMed
    gag Mouse-human CRM1 chimera analysis reveals that the amino-acid residues 146-444 of human CRM1 are important for increased HIV-1 titers in mouse cells. Three residues P411/M412/F414 are critical for human CRM1 function PubMed
    gag Human CRM1 increases HIV-1 Gag production in mouse cells. Human CRM1 and SRp40 increase the amount of unspliced HIV-1 RNA and have a more-than-additive effect on HIV-1 titers in mouse cells PubMed
    gag Human CRM1 enhances HIV-1 MA-dependent Gag membrane targeting in mouse cells PubMed
    gag Expression of CRM1 enhances Gag production 10-15 fold in rat macrophages, but only marginally in rat T cells. Expression of both CRM1 and CycT1 factors synergistically enhances Gag production to levels approximately 10-40% of those detected in human cells PubMed
    gag HIV-1 Matrix contains a nuclear export signal (amino acids 15-32) which is recognized by exportin 1 (CRM1; XPO1) and is important for nucleocytoplasmic shuttling of HIV-1 Gag and genomic RNA to the cytoplasm by exportin 1 PubMed
    Rev rev A dimeric CRM1-RanGTP complex binds a Rev-RRE complex to export the Rev-RRE complex from the nuclear to the cytoplasm in cells PubMed
    rev Computational molecular docking, alanine scanning, clustering, and evolutionary analysis reveal the interaction of DDX3 with HIV-1 Rev-CRM1-RanGTP complex PubMed
    rev Co-immunoprecipitation analysis demonstrates that endogenous RBM14 associates with HIV-1 Rev, XPO1, and p54NRB in cells PubMed
    rev The CRM1 dimer interface, including residues T346, P411, M412, F414, R474, E478, and H481, facilitates cooperative assembly with the Rev-RRE complex PubMed
    rev CRM1-mediated nuclear export of Rev involves interactions of CRM1 with RanGTP, RanBP1 and RanGEF PubMed
    rev CRM1 interacts with the nuclear export signal of Rev and acts as a bridge between Rev and nuclear pore proteins PubMed
    rev Nuclear export of Rev is dependent on its activation domain which encodes a nuclear export signal (amino acids 75-83) PubMed
    rev The addition of a second NES to HIV-1 Rev or a second RRE to Rev-dependent transcripts rescues HIV-1 virion production in murine cells independently of human CRM1 PubMed
    rev HIV-1 Rev co-localizes with CRM1 at the HIV-1 transcription site in the nucleus PubMed
    rev Human CRM1 rescues RRE/Rev-dependent HIV-1 virion production in mouse cells PubMed
    rev Rev recruitment of CRM1 to HIV-1 mRNA is sufficient to mediate nuclear export of incompletely spliced HIV-1 mRNA PubMed
    rev Ratjadone A (myxobacterial metabolite) interacts with CRM1 to inhibit the Rev-dependent HIV-1 RNA nuclear export PubMed
    rev Eukaryotic initiation factor 5A (eIF-5A) mediates the binding of CRM1 to Rev PubMed
    rev Interaction of CRM1 with nucleoporins Nup42 and Nup159 results in the release of Rev from CRM1 PubMed
    rev During Rev-mediated nuclear export of HIV-1 mRNA, Rev interacts directly with the nucleocytoplasmic mRNA-transport system PubMed
    rev Excess CRM1 may downregulate Rev-mediated RNA export by sequestering Rev to a subnucleolar structure PubMed
    rev Nuclear retention and co-localization of Rev and CRM1 is caused by down-modulation of GAP-associated tyrosine phosphoprotein p62 (Sam68), suggesting Sam68 is directly involved in the CRM1-mediated Rev nuclear export pathway PubMed
    rev HIV-1 Rev interacting protein, exportin 1 (XPO1), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells PubMed
    rev The HEAT repeat helix 9A domain (residues 402-423) of CRM1 serves as an effective cofactor for HIV-1 Rev function in higher primates PubMed
    rev Three specific domains (residues 89-123, 405-593, and 594-670) of NF90 promote Rev-RRE mediated nuclear export of Gag mRNA, which is dependent on CRM1 function PubMed
    rev HIV-1 Rev/CRM1 export complexes are observed in nucleoli by cotransfection with CFP/YFP pairs of the proteins on a large three-dimensional set of fixed cells, with Rev/CRM1 colocalization in nucleoli decreasing exponentially after addition of leptomycin B PubMed
    rev Studies suggest Rev is necessary and sufficient for the accumulation of incompletely spliced HIV RNAs at nuclear pores while CRM1 is required for translocation across the nuclear pore complex PubMed
    rev Rev-Rev interactions (multimerization) are enhanced by CRM1 PubMed
    rev The C-terminal region of Rev (amino acids 86-116) plays a role in enhancing the interaction of Rev with CRM1 PubMed
    rev CRM1 is involved in the binding of Rev to yeast Rip1 and hRip/Rab, which is involved in Rev-mediated nuclear export of HIV-1 mRNA PubMed
    rev CRM1 interacts with FG-repeat-containing nuclear pore proteins during nuclear export of Rev PubMed
    Tat tat Exportin 1 (XPO1, CRM1 homolog) is identified to interact with HIV-1 Tat mutant Nullbasic in HeLa cells by LC MS/MS PubMed
    tat Interaction of HIV-1 Tat with XPO1 in T-cells is identified by a proteomic strategy based on affinity chromatography PubMed
    Vpr vpr Nuclear export of HIV-1 Vpr by exportin-1 is required for efficient HIV replication in tissue macrophages and is important for Vpr incorporation into virions PubMed
    vpr HIV-1 Vpr contains a nuclear export signal within amino acids 1-71 that is sensitive to Leptomycin B, suggesting it is recognized by CRM1 (exportin 1) PubMed
    Vpu vpu HIV-1 Vpu is identified to have a physical interaction with exportin 1 (XPO1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
    capsid gag Human CRM1 and SRp40 have a more-than-additive effect on HIV-1 CA production in mouse cells PubMed
    matrix gag Human CRM1 enhances HIV-1 MA-dependent Gag membrane targeting in mouse cells PubMed
    gag HIV-1 Matrix contains a nuclear export signal (amino acids 15-32) which is recognized by exportin 1 (CRM1; XPO1) and is important for nucleocytoplasmic shuttling of HIV-1 Gag and genomic RNA to the cytoplasm by exportin 1 PubMed
    Items 1 - 20 of 40

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Clone Names

    • DKFZp686B1823

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding  
    enables nuclear export signal receptor activity  
    enables nuclear export signal receptor activity PubMed 
    enables nuclear export signal receptor activity PubMed 
    enables nuclear export signal receptor activity PubMed 
    enables nuclear export signal receptor activity  
    enables protein binding PubMed 
    enables small GTPase binding  
    Process Evidence Code Pubs
    involved_in mRNA export from nucleus PubMed 
    involved_in nucleocytoplasmic transport PubMed 
    involved_in protein export from nucleus PubMed 
    involved_in protein export from nucleus PubMed 
    acts_upstream_of_or_within protein export from nucleus PubMed 
    involved_in protein export from nucleus PubMed 
    involved_in protein export from nucleus PubMed 
    involved_in protein localization to nucleus  
    involved_in regulation of centrosome duplication  
    involved_in regulation of proteasomal ubiquitin-dependent protein catabolic process PubMed 
    involved_in regulation of protein export from nucleus  
    involved_in ribosomal large subunit export from nucleus  
    involved_in ribosomal large subunit export from nucleus PubMed 
    involved_in ribosomal small subunit export from nucleus  
    involved_in ribosomal small subunit export from nucleus PubMed 
    involved_in ribosomal subunit export from nucleus PubMed 
    involved_in ribosome biogenesis PubMed 
    Component Evidence Code Pubs
    located_in Cajal body  
    located_in annulate lamellae PubMed 
    is_active_in cytoplasm  
    located_in cytoplasm PubMed 
    located_in cytosol  
    located_in cytosol  
    located_in intracellular membrane-bounded organelle  
    located_in kinetochore PubMed 
    located_in membrane PubMed 
    located_in nuclear envelope PubMed 
    located_in nuclear membrane  
    located_in nucleolus PubMed 
    located_in nucleoplasm  
    located_in nucleoplasm  
    is_active_in nucleus  
    part_of protein-containing complex PubMed 
    part_of ribonucleoprotein complex PubMed 

    General protein information

    Preferred Names
    exportin-1
    Names
    chromosome region maintenance 1 homolog
    chromosome region maintenance 1 protein homolog
    exportin 1 (CRM1 homolog, yeast)
    exportin-1 (required for chromosome region maintenance)

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001410799.1 → NP_001397728.1  exportin-1 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC016727
      Consensus CDS
      CCDS92765.1
      UniProtKB/TrEMBL
      A0A7I2V2Y6, A0A7I2V3W6
      Related
      ENSP00000502940.1, ENST00000676999.1
    2. NM_003400.4 → NP_003391.1  exportin-1 isoform 1

      See identical proteins and their annotated locations for NP_003391.1

      Status: REVIEWED

      Source sequence(s)
      AC016727, AK124769, AL833550, BC032847, BX492941, BX643790, BX647758, BX954288, CR749840, Y08614
      Consensus CDS
      CCDS33205.1
      UniProtKB/Swiss-Prot
      A6NL14, A8K1K5, D6W5E2, O14980, Q63HP8, Q68CP3, Q99433
      UniProtKB/TrEMBL
      A0A7I2V3W6
      Related
      ENSP00000384863.2, ENST00000401558.7
      Conserved Domains (1) summary
      COG5101
      Location:15 → 1044
      CRM1; Importin beta-related nuclear transport receptor [Nuclear structure / Intracellular trafficking and secretion]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      61477849..61538612 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047445764.1 → XP_047301720.1  exportin-1 isoform X2

      UniProtKB/TrEMBL
      A0A7I2V2H0, A0A7I2V461
      Related
      ENSP00000503808.1, ENST00000676771.1
    2. XM_011533097.2 → XP_011531399.1  exportin-1 isoform X1

      See identical proteins and their annotated locations for XP_011531399.1

      UniProtKB/Swiss-Prot
      A6NL14, A8K1K5, D6W5E2, O14980, Q63HP8, Q68CP3, Q99433
      UniProtKB/TrEMBL
      A0A7I2V3W6
      Related
      ENSP00000504247.1, ENST00000676553.1
      Conserved Domains (1) summary
      COG5101
      Location:15 → 1044
      CRM1; Importin beta-related nuclear transport receptor [Nuclear structure / Intracellular trafficking and secretion]
    3. XM_047445771.1 → XP_047301727.1  exportin-1 isoform X4

      UniProtKB/TrEMBL
      A0A7I2V2H0
    4. XM_005264544.3 → XP_005264601.1  exportin-1 isoform X2

      UniProtKB/TrEMBL
      A0A7I2V2H0, A0A7I2V461
      Conserved Domains (1) summary
      COG5101
      Location:15 → 1029
      CRM1; Importin beta-related nuclear transport receptor [Nuclear structure / Intracellular trafficking and secretion]
    5. XM_011533098.3 → XP_011531400.1  exportin-1 isoform X3

      See identical proteins and their annotated locations for XP_011531400.1

      UniProtKB/TrEMBL
      A0A7I2V2Y6, A0A7I2V3W6
      Related
      ENSP00000503194.1, ENST00000678081.1
      Conserved Domains (1) summary
      COG5101
      Location:15 → 999
      CRM1; Importin beta-related nuclear transport receptor [Nuclear structure / Intracellular trafficking and secretion]
    6. XM_047445761.1 → XP_047301717.1  exportin-1 isoform X2

      UniProtKB/TrEMBL
      A0A7I2V2H0, A0A7I2V461
    7. XM_047445767.1 → XP_047301723.1  exportin-1 isoform X3

      UniProtKB/TrEMBL
      A0A7I2V2Y6, A0A7I2V3W6
      Conserved Domains (1) summary
      COG5101
      Location:15 → 999
      CRM1; Importin beta-related nuclear transport receptor [Nuclear structure / Intracellular trafficking and secretion]
    8. XM_047445760.1 → XP_047301716.1  exportin-1 isoform X1

      UniProtKB/Swiss-Prot
      A6NL14, A8K1K5, D6W5E2, O14980, Q63HP8, Q68CP3, Q99433
      UniProtKB/TrEMBL
      A0A7I2V3W6
      Related
      ENSP00000504087.1, ENST00000677239.1
    9. XM_047445765.1 → XP_047301721.1  exportin-1 isoform X2

      UniProtKB/TrEMBL
      A0A7I2V2H0, A0A7I2V461
    10. XM_047445759.1 → XP_047301715.1  exportin-1 isoform X1

      UniProtKB/Swiss-Prot
      A6NL14, A8K1K5, D6W5E2, O14980, Q63HP8, Q68CP3, Q99433
      UniProtKB/TrEMBL
      A0A7I2V3W6
    11. XM_047445762.1 → XP_047301718.1  exportin-1 isoform X2

      UniProtKB/TrEMBL
      A0A7I2V2H0, A0A7I2V461
    12. XM_047445768.1 → XP_047301724.1  exportin-1 isoform X3

      UniProtKB/TrEMBL
      A0A7I2V2Y6, A0A7I2V3W6
      Conserved Domains (1) summary
      COG5101
      Location:15 → 999
      CRM1; Importin beta-related nuclear transport receptor [Nuclear structure / Intracellular trafficking and secretion]
    13. XM_006712094.4 → XP_006712157.1  exportin-1 isoform X1

      See identical proteins and their annotated locations for XP_006712157.1

      UniProtKB/Swiss-Prot
      A6NL14, A8K1K5, D6W5E2, O14980, Q63HP8, Q68CP3, Q99433
      UniProtKB/TrEMBL
      A0A7I2V3W6
      Related
      ENSP00000503167.1, ENST00000677150.1
      Conserved Domains (1) summary
      COG5101
      Location:15 → 1044
      CRM1; Importin beta-related nuclear transport receptor [Nuclear structure / Intracellular trafficking and secretion]
    14. XM_047445763.1 → XP_047301719.1  exportin-1 isoform X2

      UniProtKB/TrEMBL
      A0A7I2V2H0, A0A7I2V461
    15. XM_047445769.1 → XP_047301725.1  exportin-1 isoform X3

      UniProtKB/TrEMBL
      A0A7I2V2Y6, A0A7I2V3W6
      Conserved Domains (1) summary
      COG5101
      Location:15 → 999
      CRM1; Importin beta-related nuclear transport receptor [Nuclear structure / Intracellular trafficking and secretion]
    16. XM_047445758.1 → XP_047301714.1  exportin-1 isoform X1

      UniProtKB/Swiss-Prot
      A6NL14, A8K1K5, D6W5E2, O14980, Q63HP8, Q68CP3, Q99433
      UniProtKB/TrEMBL
      A0A7I2V3W6
    17. XM_024453125.2 → XP_024308893.1  exportin-1 isoform X1

      UniProtKB/Swiss-Prot
      A6NL14, A8K1K5, D6W5E2, O14980, Q63HP8, Q68CP3, Q99433
      UniProtKB/TrEMBL
      A0A7I2V3W6
      Related
      ENSP00000385942.2, ENST00000404992.6
      Conserved Domains (1) summary
      COG5101
      Location:15 → 1044
      CRM1; Importin beta-related nuclear transport receptor [Nuclear structure / Intracellular trafficking and secretion]
    18. XM_047445766.1 → XP_047301722.1  exportin-1 isoform X2

      UniProtKB/TrEMBL
      A0A7I2V2H0, A0A7I2V461
    19. XM_024453127.2 → XP_024308895.1  exportin-1 isoform X6

      UniProtKB/TrEMBL
      A0A7I2V488, A0A7I2V6B9
      Conserved Domains (1) summary
      COG5101
      Location:1 → 913
      CRM1; Importin beta-related nuclear transport receptor [Nuclear structure / Intracellular trafficking and secretion]
    20. XM_047445772.1 → XP_047301728.1  exportin-1 isoform X5

      UniProtKB/TrEMBL
      A0A7I2V3W6
      Related
      ENSP00000503702.1, ENST00000677803.1
    21. XM_005264546.3 → XP_005264603.1  exportin-1 isoform X6

      See identical proteins and their annotated locations for XP_005264603.1

      UniProtKB/TrEMBL
      A0A7I2V488, A0A7I2V6B9
      Related
      ENSP00000504749.1, ENST00000677556.1
      Conserved Domains (1) summary
      COG5101
      Location:1 → 913
      CRM1; Importin beta-related nuclear transport receptor [Nuclear structure / Intracellular trafficking and secretion]
    22. XM_047445773.1 → XP_047301729.1  exportin-1 isoform X6

      UniProtKB/TrEMBL
      A0A7I2V488, A0A7I2V6B9
      Related
      ENSP00000503789.1, ENST00000677476.1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      61483936..61544825 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054343778.1 → XP_054199753.1  exportin-1 isoform X1

      UniProtKB/Swiss-Prot
      A6NL14, A8K1K5, D6W5E2, O14980, Q63HP8, Q68CP3, Q99433
      UniProtKB/TrEMBL
      A0A7I2V3W6
    2. XM_054343783.1 → XP_054199758.1  exportin-1 isoform X2

      UniProtKB/TrEMBL
      A0A7I2V2H0, A0A7I2V461
    3. XM_054343790.1 → XP_054199765.1  exportin-1 isoform X4

      UniProtKB/TrEMBL
      A0A7I2V2H0
    4. XM_054343779.1 → XP_054199754.1  exportin-1 isoform X2

      UniProtKB/TrEMBL
      A0A7I2V2H0, A0A7I2V461
    5. XM_054343786.1 → XP_054199761.1  exportin-1 isoform X3

      UniProtKB/TrEMBL
      A0A7I2V2Y6, A0A7I2V3W6
    6. XM_054343780.1 → XP_054199755.1  exportin-1 isoform X2

      UniProtKB/TrEMBL
      A0A7I2V2H0, A0A7I2V461
    7. XM_054343787.1 → XP_054199762.1  exportin-1 isoform X3

      UniProtKB/TrEMBL
      A0A7I2V2Y6, A0A7I2V3W6
    8. XM_054343777.1 → XP_054199752.1  exportin-1 isoform X1

      UniProtKB/Swiss-Prot
      A6NL14, A8K1K5, D6W5E2, O14980, Q63HP8, Q68CP3, Q99433
      UniProtKB/TrEMBL
      A0A7I2V3W6
    9. XM_054343784.1 → XP_054199759.1  exportin-1 isoform X2

      UniProtKB/TrEMBL
      A0A7I2V2H0, A0A7I2V461
    10. XM_054343776.1 → XP_054199751.1  exportin-1 isoform X1

      UniProtKB/Swiss-Prot
      A6NL14, A8K1K5, D6W5E2, O14980, Q63HP8, Q68CP3, Q99433
      UniProtKB/TrEMBL
      A0A7I2V3W6
    11. XM_054343781.1 → XP_054199756.1  exportin-1 isoform X2

      UniProtKB/TrEMBL
      A0A7I2V2H0, A0A7I2V461
    12. XM_054343788.1 → XP_054199763.1  exportin-1 isoform X3

      UniProtKB/TrEMBL
      A0A7I2V2Y6, A0A7I2V3W6
    13. XM_054343775.1 → XP_054199750.1  exportin-1 isoform X1

      UniProtKB/Swiss-Prot
      A6NL14, A8K1K5, D6W5E2, O14980, Q63HP8, Q68CP3, Q99433
      UniProtKB/TrEMBL
      A0A7I2V3W6
    14. XM_054343782.1 → XP_054199757.1  exportin-1 isoform X2

      UniProtKB/TrEMBL
      A0A7I2V2H0, A0A7I2V461
    15. XM_054343789.1 → XP_054199764.1  exportin-1 isoform X3

      UniProtKB/TrEMBL
      A0A7I2V2Y6, A0A7I2V3W6
    16. XM_054343774.1 → XP_054199749.1  exportin-1 isoform X1

      UniProtKB/Swiss-Prot
      A6NL14, A8K1K5, D6W5E2, O14980, Q63HP8, Q68CP3, Q99433
      UniProtKB/TrEMBL
      A0A7I2V3W6
    17. XM_054343773.1 → XP_054199748.1  exportin-1 isoform X1

      UniProtKB/Swiss-Prot
      A6NL14, A8K1K5, D6W5E2, O14980, Q63HP8, Q68CP3, Q99433
      UniProtKB/TrEMBL
      A0A7I2V3W6
    18. XM_054343785.1 → XP_054199760.1  exportin-1 isoform X2

      UniProtKB/TrEMBL
      A0A7I2V2H0, A0A7I2V461
    19. XM_054343792.1 → XP_054199767.1  exportin-1 isoform X6

      UniProtKB/TrEMBL
      A0A7I2V488, A0A7I2V6B9
    20. XM_054343791.1 → XP_054199766.1  exportin-1 isoform X5

      UniProtKB/TrEMBL
      A0A7I2V3W6
    21. XM_054343793.1 → XP_054199768.1  exportin-1 isoform X6

      UniProtKB/TrEMBL
      A0A7I2V488, A0A7I2V6B9
    22. XM_054343794.1 → XP_054199769.1  exportin-1 isoform X6

      UniProtKB/TrEMBL
      A0A7I2V488, A0A7I2V6B9
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