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    emrY tripartite efflux pump membrane subunit EmrY [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946835, updated on 3-Dec-2024

    Summary

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    Official Symbol
    emrY
    Official Full Name
    tripartite efflux pump membrane subunit EmrY
    Primary source
    ECOCYC:EG13283
    Locus tag
    b2367
    See related
    ASAP:ABE-0007806
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2363
    Summary
    EvgAS regulon. [More information is available at EcoGene: EG13283]. EmrY is a putative multidrug efflux protein belonging to the major facilitator superfamily (MFS) of transporters . [More information is available at EcoCyc: EG13283].
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    Genomic context

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    Sequence:
    NC_000913.3 (2480638..2482176, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene D-serine transporter Neighboring gene D-serine ammonia-lyase Neighboring gene tripartite efflux pump membrane fusion protein EmrK Neighboring gene protein EvgL Neighboring gene DNA-binding transcriptional activator EvgA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Induction of multidrug resistance mechanism in Escherichia coli biofilms by interplay between tetracycline and ampicillin resistance genes. May T, et al. Antimicrob Agents Chemother, 2009 Nov. PMID 19721076, Free PMC Article
    2. Transcription of emrKY is regulated by the EvgA-EvgS two-component system in Escherichia coli K-12. Kato A, et al. Biosci Biotechnol Biochem, 2000 Jun. PMID 10923791
    3. Proton-dependent multidrug efflux systems. Paulsen IT, et al. Microbiol Rev, 1996 Dec. PMID 8987357, Free PMC Article
    4. Overexpression of the response regulator evgA of the two-component signal transduction system modulates multidrug resistance conferred by multidrug resistance transporters. Nishino K, et al. J Bacteriol, 2001 Feb. PMID 11157960, Free PMC Article
    5. Growth phase-dependent transcription of emrKY, a homolog of multidrug efflux emrAB genes of Escherichia coli, is induced by tetracycline. Tanabe H, et al. J Gen Appl Microbiol, 1997 Oct. PMID 12501312

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA damage response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within bile acid and bile salt transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to antibiotic IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in xenobiotic detoxification by transmembrane export across the cell outer membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within xenobiotic detoxification by transmembrane export across the plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of efflux pump complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in periplasmic side of plasma membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tripartite efflux pump membrane subunit EmrY

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2480638..2482176 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416868.1 tripartite efflux pump membrane subunit EmrY [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416868.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376M4M9
      Conserved Domains (1) summary
      NF000391
      Location:10 → 508
      EmrB; multidrug efflux MFS transporter permease subunit EmrB
    Nucleotide Protein
    Heading Accession and Version

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