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    Hspa12a heat shock protein 12A [ Mus musculus (house mouse) ]

    Gene ID: 73442, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Hspa12aprovided by MGI
    Official Full Name
    heat shock protein 12Aprovided by MGI
    Primary source
    MGI:MGI:1920692
    See related
    Ensembl:ENSMUSG00000025092 AllianceGenome:MGI:1920692
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D5Mgi40; Gm19925; mKIAA0417; 1700063D12Rik
    Summary
    Predicted to enable ATP binding activity. Predicted to be located in cytoplasm and nucleus. Is expressed in nervous system; retina; and white fat. Orthologous to human HSPA12A (heat shock protein family A (Hsp70) member 12A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in cortex adult (RPKM 20.3), CNS E18 (RPKM 18.9) and 20 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Hspa12a in Genome Data Viewer
    Location:
    19 D2; 19 54.51 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (58784182..58932104, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (58795750..58943672, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 52394 Neighboring gene sperm microtubule inner protein 5 Neighboring gene predicted gene, 41877 Neighboring gene STARR-positive B cell enhancer ABC_E10000 Neighboring gene STARR-seq mESC enhancer starr_46586 Neighboring gene predicted gene, 52393 Neighboring gene STARR-seq mESC enhancer starr_46588 Neighboring gene microRNA 3086 Neighboring gene enolase 4 Neighboring gene STARR-seq mESC enhancer starr_46589 Neighboring gene shootin 1 Neighboring gene predicted gene, 57667

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. HSPA12A maintains aerobic glycolytic homeostasis and Histone3 lactylation in cardiomyocytes to attenuate myocardial ischemia/reperfusion injury. Yu W, et al. JCI Insight, 2024 Apr 8. PMID 38421727, Free PMC Article
    2. HSPA12A controls cerebral lactate homeostasis to maintain hippocampal neurogenesis and mood stabilization. Wang J, et al. Transl Psychiatry, 2023 Aug 14. PMID 37580315, Free PMC Article
    3. Hepatocyte HSPA12A inhibits macrophage chemotaxis and activation to attenuate liver ischemia/reperfusion injury via suppressing glycolysis-mediated HMGB1 lactylation and secretion of hepatocytes. Du S, et al. Theranostics, 2023. PMID 37441587, Free PMC Article
    4. Roles of heat shock protein A12A in the development of diabetic cardiomyopathy. Jia Y, et al. Cell Stress Chaperones, 2024 Apr. PMID 38485044, Free PMC Article
    5. HSPA12A Is a Novel Player in Nonalcoholic Steatohepatitis via Promoting Nuclear PKM2-Mediated M1 Macrophage Polarization. Kong Q, et al. Diabetes, 2019 Feb. PMID 30455376

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Roles of heat shock protein A12A in the development of diabetic cardiomyopathy.
      Title: Roles of heat shock protein A12A in the development of diabetic cardiomyopathy.
    2. HSPA12A maintains aerobic glycolytic homeostasis and Histone3 lactylation in cardiomyocytes to attenuate myocardial ischemia/reperfusion injury.
      Title: HSPA12A maintains aerobic glycolytic homeostasis and Histone3 lactylation in cardiomyocytes to attenuate myocardial ischemia/reperfusion injury.
    3. HSPA12A controls cerebral lactate homeostasis to maintain hippocampal neurogenesis and mood stabilization.
      Title: HSPA12A controls cerebral lactate homeostasis to maintain hippocampal neurogenesis and mood stabilization.
    4. HSPA12A Stimulates p38/ERK-AP-1 Signaling to Promote Angiogenesis and Is Required for Functional Recovery Postmyocardial Infarction.
      Title: HSPA12A Stimulates p38/ERK-AP-1 Signaling to Promote Angiogenesis and Is Required for Functional Recovery Postmyocardial Infarction.
    5. HSPA12A attenuates lipopolysaccharide-induced liver injury through inhibiting caspase-11-mediated hepatocyte pyroptosis via PGC-1alpha-dependent acyloxyacyl hydrolase expression.
      Title: HSPA12A attenuates lipopolysaccharide-induced liver injury through inhibiting caspase-11-mediated hepatocyte pyroptosis via PGC-1α-dependent acyloxyacyl hydrolase expression.
    6. HSPA12A is required for adipocyte differentiation and diet-induced obesity through a positive feedback regulation with PPARgamma.
      Title: HSPA12A is required for adipocyte differentiation and diet-induced obesity through a positive feedback regulation with PPARγ.
    7. Deficiency of Hspa12a promotes browning of white adipose tissues in mice.
      Title: Deficiency of heat shock protein A12A promotes browning of white adipose tissues in mice.
    8. findings suggest that HSPA12A expression encodes a critical novel prosurvival pathway during ischaemic stroke.
      Title: Heat shock protein A12A encodes a novel prosurvival pathway during ischaemic stroke.
    9. HSPA12A and HSPA12B may play roles in genetic susceptibility to atherosclerosis
      Title: Two Hsp70 family members expressed in atherosclerotic lesions.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (1)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    heat shock 70 kDa protein 12A
    Names
    heat shock 70kDa protein 12A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001327998.1 → NP_001314927.1  heat shock 70 kDa protein 12A isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AK087732, AK141925, BQ176746, BY240671
      UniProtKB/Swiss-Prot
      Q8K0U4
      Conserved Domains (1) summary
      cd11735
      Location:75 → 541
      HSPA12A_like_NBD; Nucleotide-binding domain of HSPA12A and similar proteins

    2. NM_175199.3 → NP_780408.1  heat shock 70 kDa protein 12A isoform 2

      See identical proteins and their annotated locations for NP_780408.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate 5' terminal exon and uses an alternate start codon, compared to variant 1. It encodes isoform 2, which has a shorter and distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AK141925
      Consensus CDS
      CCDS38032.1
      UniProtKB/Swiss-Prot
      Q3UQZ8, Q8CHF6, Q8K0U4
      Related
      ENSMUSP00000066860.5, ENSMUST00000066285.6
      Conserved Domains (1) summary
      cd11735
      Location:57 → 523
      HSPA12A_like_NBD; Nucleotide-binding domain of HSPA12A and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      58784182..58932104 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011247368.4 → XP_011245670.1  heat shock 70 kDa protein 12A isoform X2

      Conserved Domains (1) summary
      cd11735
      Location:46 → 512
      HSPA12A_like_NBD; Nucleotide-binding domain of HSPA12A and similar proteins

    2. XM_006527377.3 → XP_006527440.1  heat shock 70 kDa protein 12A isoform X1

      Conserved Domains (1) summary
      cd11735
      Location:77 → 543
      HSPA12A_like_NBD; Nucleotide-binding domain of HSPA12A and similar proteins

    3. XM_006527379.5 → XP_006527442.1  heat shock 70 kDa protein 12A isoform X3

      Conserved Domains (1) summary
      cl17037
      Location:1 → 440
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

    4. XM_036161702.1 → XP_036017595.1  heat shock 70 kDa protein 12A isoform X4

      Conserved Domains (1) summary
      cl17037
      Location:24 → 268
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

    5. XM_036161704.1 → XP_036017597.1  heat shock 70 kDa protein 12A isoform X4

      Conserved Domains (1) summary
      cl17037
      Location:24 → 268
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

    6. XM_036161703.1 → XP_036017596.1  heat shock 70 kDa protein 12A isoform X4

      Conserved Domains (1) summary
      cl17037
      Location:24 → 268
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K0U4.1 GenPept UniProtKB/Swiss-Prot:Q8K0U4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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