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    ZNF785 zinc finger protein 785 [ Homo sapiens (human) ]

    Gene ID: 146540, updated on 10-Dec-2024

    Summary

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    Official Symbol
    ZNF785provided by HGNC
    Official Full Name
    zinc finger protein 785provided by HGNC
    Primary source
    HGNC:HGNC:26496
    See related
    Ensembl:ENSG00000197162 AllianceGenome:HGNC:26496
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZNF688
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in endometrium (RPKM 2.1), ovary (RPKM 1.9) and 25 other tissues See more
    Orthologs
    all
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    Genomic context

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    See ZNF785 in Genome Data Viewer
    Location:
    16p11.2
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (30578361..30585697, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (30965340..30972758, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (30591977..30597018, complement)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:30552221-30552866 Neighboring gene uncharacterized LOC124903677 Neighboring gene Sharpr-MPRA regulatory region 8694 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:30564727-30565226 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:30568583-30569144 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10712 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10713 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10714 Neighboring gene zinc finger protein 764 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10715 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:30580811-30581376 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:30581377-30581940 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7379 Neighboring gene zinc finger protein 688 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:30596216-30596816 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7380 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:30597418-30598018 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7381 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:30621737-30622706 Neighboring gene uncharacterized LOC124903678 Neighboring gene zinc finger protein 689 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:30626940-30627180 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:30644787-30645738 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:30645739-30646689 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:30661003-30661520 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:30661521-30662036 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7382 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7383 Neighboring gene proline rich 14

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. Loftus BJ, et al. Genomics, 1999 Sep 15. PMID 10493829
    2. Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells. Chang YJ, et al. Int J Mol Sci, 2023 Jun 6. PMID 37372979, Free PMC Article
    3. N(6)-Methyladenosine on mRNA facilitates a phase-separated nuclear body that suppresses myeloid leukemic differentiation. Cheng Y, et al. Cancer Cell, 2021 Jul 12. PMID 34048709, Free PMC Article
    4. Identification of host proteins required for HIV infection through a functional genomic screen. Brass AL, et al. Science, 2008 Feb 15. PMID 18187620
    5. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. Brandenberger R, et al. Nat Biotechnol, 2004 Jun. PMID 15146197

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Knockdown of zinc finger protein 785 (ZNF785) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ32130

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 785
    Names
    Zinc finger protein 688

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_152458.7 → NP_689671.2  zinc finger protein 785

      See identical proteins and their annotated locations for NP_689671.2

      Status: VALIDATED

      Source sequence(s)
      AC002310, BC040642, CN401082
      Consensus CDS
      CCDS10685.1
      UniProtKB/Swiss-Prot
      A8K8V0
      UniProtKB/TrEMBL
      B4DQL1
      Related
      ENSP00000378642.2, ENST00000395216.3
      Conserved Domains (3) summary
      smart00349
      Location:29 → 89
      KRAB; krueppel associated box
      COG5048
      Location:143 → 359
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:174 → 194
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      30578361..30585697 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017022967.3 → XP_016878456.1  zinc finger protein 785 isoform X2

      UniProtKB/Swiss-Prot
      A8K8V0
      UniProtKB/TrEMBL
      B4DQL1
      Related
      ENSP00000420340.1, ENST00000470110.2
      Conserved Domains (3) summary
      smart00349
      Location:29 → 89
      KRAB; krueppel associated box
      COG5048
      Location:143 → 359
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:174 → 194
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. XM_011545753.3 → XP_011544055.1  zinc finger protein 785 isoform X1

      See identical proteins and their annotated locations for XP_011544055.1

      UniProtKB/TrEMBL
      B4DQL1
      Conserved Domains (3) summary
      smart00349
      Location:29 → 102
      KRAB; krueppel associated box
      COG5048
      Location:156 → 372
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:187 → 207
      ZF_C2H2; C2H2 Zn finger [structural motif]

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      30965340..30972758 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054379677.1 → XP_054235652.1  zinc finger protein 785 isoform X1

      UniProtKB/TrEMBL
      B4DQL1

    2. XM_054379678.1 → XP_054235653.1  zinc finger protein 785 isoform X2

      UniProtKB/Swiss-Prot
      A8K8V0
      UniProtKB/TrEMBL
      B4DQL1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A8K8V0.1 GenPept UniProtKB/Swiss-Prot:A8K8V0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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