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    cusC copper/silver export system outer membrane channel [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946288, updated on 17-Dec-2024

    Summary

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    Official Symbol
    cusC
    Official Full Name
    copper/silver export system outer membrane channel
    Primary source
    ECOCYC:G6320
    Locus tag
    b0572
    See related
    ASAP:ABE-0001958
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0564; ibeB; ylcB
    Summary
    cusC is in the cusCFBA Cu/Ag efflux operon regulated by Cu and Ag. [More information is available at EcoGene: EG14233]. CusC is an outer membrane factor involved in the detoxification of copper and silver ions in Escherichia coli as part of the CusCFBA copper/silver efflux system. [More information is available at EcoCyc: G6320].
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    Genomic context

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    Sequence:
    NC_000913.3 (595600..596973)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene exopolysaccharide secretion system outer membrane protein NfrA Neighboring gene cyclic di-3',5'-guanylate-activated glycosyltransferase Neighboring gene sensor histidine kinase CusS Neighboring gene DNA-binding transcriptional activator CusR Neighboring gene copper/silver export system periplasmic binding protein Neighboring gene copper/silver export system membrane fusion protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Crystal structures of CusC review conformational changes accompanying folding and transmembrane channel formation. Lei HT, et al. J Mol Biol, 2014 Jan 23. PMID 24099674, Free PMC Article
    2. Identification and characterization of an Escherichia coli invasion gene locus, ibeB, required for penetration of brain microvascular endothelial cells. Huang SH, et al. Infect Immun, 1999 May. PMID 10225861, Free PMC Article
    3. [Characterization of ibeB gene of meningitic Escherichia coli strains in calves from Xinjiang]. Ling C, et al. Wei Sheng Wu Xue Bao, 2016 Jun 4. PMID 29727554
    4. Characterization of the copper(II) binding site in the pink copper binding protein CusF by electron paramagnetic resonance spectroscopy. Astashkin AV, et al. J Biol Inorg Chem, 2005 May. PMID 15770503
    5. Silver-resistant mutants of Escherichia coli display active efflux of Ag+ and are deficient in porins. Li XZ, et al. J Bacteriol, 1997 Oct. PMID 9324262, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables copper ion binding IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables copper ion transmembrane transporter activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables diacylglycerol binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables efflux transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables porin activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within copper ion export IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within copper ion export IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in copper ion export NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in copper ion transmembrane transport NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within detoxification of copper ion IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within intracellular copper ion homeostasis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein homotrimerization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein homotrimerization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within response to copper ion IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to copper ion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to silver ion IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to silver ion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to toxic substance NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in silver ion transmembrane transport NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell outer membrane RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of pore complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    copper/silver export system outer membrane channel

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      595600..596973
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415104.1 copper/silver export system outer membrane channel [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415104.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8S7EG87
      Conserved Domains (1) summary
      PRK09837
      Location:1 → 457
      PRK09837; Cu(I)/Ag(I) efflux RND transporter outer membrane protein
    Nucleotide Protein
    Heading Accession and Version

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