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    rluE 23S rRNA pseudouridine(2457) synthase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945701, updated on 17-Dec-2024

    Summary

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    Official Symbol
    rluE
    Official Full Name
    23S rRNA pseudouridine(2457) synthase
    Primary source
    ECOCYC:G6581
    Locus tag
    b1135
    See related
    ASAP:ABE-0003820
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1121; ymfC
    Summary
    AFMB Structural Genomics target Number 19 (http://afmb.cnrs-mrs.fr/article171.html). [More information is available at EcoGene: EG13447]. RluE is the pseudouridine synthase that catalyzes formation of pseudouridine at position 2457 in 23S rRNA. [More information is available at EcoCyc: G6581].
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    Genomic context

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    Sequence:
    NC_000913.3 (1194298..1194951, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene tRNA-specific 2-thiouridylase Neighboring gene phosphatase NudJ Neighboring gene isocitrate dehydrogenase Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular Determinants for 23S rRNA Recognition and Modification by the E. coli Pseudouridine Synthase RluE. Tillault AS, et al. J Mol Biol, 2018 Apr 27. PMID 29555553
    2. The crystal structure of E. coli rRNA pseudouridine synthase RluE. Pan H, et al. J Mol Biol, 2007 Apr 13. PMID 17320904, Free PMC Article
    3. An indigenous posttranscriptional modification in the ribosomal peptidyl transferase center confers resistance to an array of protein synthesis inhibitors. Toh SM, et al. J Mol Biol, 2008 Jul 18. PMID 18554609, Free PMC Article
    4. Four newly located pseudouridylate residues in Escherichia coli 23S ribosomal RNA are all at the peptidyltransferase center: analysis by the application of a new sequencing technique. Bakin A, et al. Biochemistry, 1993 Sep 21. PMID 8373778
    5. Identification and site of action of the remaining four putative pseudouridine synthases in Escherichia coli. Del Campo M, et al. RNA, 2001 Nov. PMID 11720289, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The crystal structure of E. coli rRNA pseudouridine synthase RluE.
      Title: The crystal structure of E. coli rRNA pseudouridine synthase RluE.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables 23S rRNA pseudouridine(2457) synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables catalytic activity, acting on RNA IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pseudouridine synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pseudouridine synthase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables rRNA pseudouridine synthase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within enzyme-directed rRNA pseudouridine synthesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pseudouridine synthesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    23S rRNA pseudouridine(2457) synthase
    NP_415653.4

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1194298..1194951 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415653.4 23S rRNA pseudouridine(2457) synthase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415653.4

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8S7FJR9
      Conserved Domains (1) summary
      PRK11394
      Location:1 → 217
      PRK11394; 23S rRNA pseudouridine(2457) synthase RluE
    Nucleotide Protein
    Heading Accession and Version

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