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    mtn 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948542, updated on 3-Dec-2024

    Summary

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    Official Symbol
    mtn
    Official Full Name
    5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase
    Primary source
    ECOCYC:EG11090
    Locus tag
    b0159
    See related
    ASAP:ABE-0000545
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0158; mtnN; pfs; yadA
    Summary
    Mutants accumulate 5'-deoxyadenosine and have impaired biotin synthase activity. [More information is available at EcoGene: EG11090]. The mtn gene encodes 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase . [More information is available at EcoCyc: EG11090].
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    Genomic context

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    Sequence:
    NC_000913.3 (178455..179153, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene protein YadW Neighboring gene iron-sulfur cluster insertion protein ErpA Neighboring gene PF03458 family protein YadS Neighboring gene vitamin B12 ABC transporter periplasmic binding protein Neighboring gene dGTP triphosphohydrolase Neighboring gene periplasmic serine endoprotease DegP

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The catalytic mechanism of adenosylhomocysteine/methylthioadenosine nucleosidase from Escherichia coli--chemical evidence for a transition state with a substantial oxocarbenium character. Allart B, et al. Eur J Biochem, 1998 Aug 15. PMID 9746359
    2. Structure of Escherichia coli 5'-methylthioadenosine/ S-adenosylhomocysteine nucleosidase inhibitor complexes provide insight into the conformational changes required for substrate binding and catalysis. Lee JE, et al. J Biol Chem, 2003 Mar 7. PMID 12496243
    3. pfs-dependent regulation of autoinducer 2 production in Salmonella enterica serovar Typhimurium. Beeston AL, et al. J Bacteriol, 2002 Jul. PMID 12057938, Free PMC Article
    4. Structural rationale for the affinity of pico- and femtomolar transition state analogues of Escherichia coli 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase. Lee JE, et al. J Biol Chem, 2005 May 6. PMID 15746096
    5. Femtomolar transition state analogue inhibitors of 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase from Escherichia coli. Singh V, et al. J Biol Chem, 2005 May 6. PMID 15749708

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The transition-state analogue affinity and thermodynamics in mutant VcMTAN became even more unlike those of EcMTAN, the opposite of expectations from catalytic site similarity
      Title: Active site and remote contributions to catalysis in methylthioadenosine nucleosidases.
    2. Pfs and LuxS synthesize AI-2 in vitro from S-ribosylhomocysteine.
      Title: [Cloning and expression of luxS and pfs and in vitro biosynthesis autoinducer 2 of avian pathogenic Escherichia coli from Anhui Province].
    3. Pfs transcription is shown to rely on both sigma 70 and sigma 38 (rpoS), and the latter is subject to induction that increases pfs expression
      Title: Escherichia coli pfs transcription: regulation and proposed roles in autoinducer-2 synthesis and purine excretion.
    4. transition state structure investigated using multiple kinetic isotope effects and its geometric and electrostatic properties obtained using density functional methods
      Title: Transition state structure of 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase from Escherichia coli and its similarity to transition state analogues.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    General protein information

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    Preferred Names
    5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase
    NP_414701.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      178455..179153 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_414701.1 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_414701.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376MCL3
      Conserved Domains (1) summary
      PRK05584
      Location:1 → 230
      PRK05584; 5'-methylthioadenosine/adenosylhomocysteine nucleosidase
    Nucleotide Protein
    Heading Accession and Version

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