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    UBA2A UBP1-associated protein 2A [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 824853, updated on 18-Sep-2024

    Summary

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    Official Symbol
    UBA2A
    Official Full Name
    UBP1-associated protein 2A
    Primary source
    TAIR:AT3G56860
    Locus tag
    AT3G56860
    See related
    Araport:AT3G56860
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    UBP1-associated protein 2A
    Summary
    encodes a nuclear protein that binds to RNA with a specificity for oligouridylates in vitro. Along with UBP1 and UBA1a, it may act as a component of a complex recognizing U-rich sequences in plant 3'-UTRs and contributing to the stabilization of mRNAs in the nucleus.
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    Genomic context

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    See UBA2A in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    2
    Sequence:
    Chromosome: 3; NC_003074.8 (21048727..21052320, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene YCF20-like protein (DUF565) Neighboring gene ncRNA Neighboring gene FAD-dependent oxidoreductase family protein Neighboring gene ABA-responsive element binding protein 3 Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Modulation of an RNA-binding protein by abscisic-acid-activated protein kinase. Li J, et al. Nature, 2002 Aug 15. PMID 12181571
    2. Arabidopsis RNA-binding protein UBA2a relocalizes into nuclear speckles in response to abscisic acid. Riera M, et al. FEBS Lett, 2006 Jul 24. PMID 16828085
    3. Overexpression of wound-responsive RNA-binding proteins induces leaf senescence and hypersensitive-like cell death. Kim CY, et al. New Phytol, 2008. PMID 18705666
    4. Characterization of wound-responsive RNA-binding proteins and their splice variants in Arabidopsis. Bove J, et al. Plant Mol Biol, 2008 May. PMID 18278441
    5. UBA1 and UBA2, two proteins that interact with UBP1, a multifunctional effector of pre-mRNA maturation in plants. Lambermon MH, et al. Mol Cell Biol, 2002 Jun. PMID 12024044, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. UBA2 gene expression stimulates leaf yellowing and cell death phenotypes through senescence and defense response pathways.
      Title: Overexpression of wound-responsive RNA-binding proteins induces leaf senescence and hypersensitive-like cell death.
    2. UBA2A encodes an hnRNP-type nuclear RNA-binding protein that functions in a novel wound signal transduction pathway.
      Title: Characterization of wound-responsive RNA-binding proteins and their splice variants in Arabidopsis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001203180.2
    NM_001203181.1
    NM_001339826.1
    NM_001339827.1
    NM_001339828.1
    NM_001339829.1
    NM_001339830.1
    NM_001339831.1
    NM_115545.4
    NM_180379.4
    NM_180380.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables mRNA 3'-UTR AU-rich region binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mRNA binding HDA PubMed 
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within abscisic acid-activated signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within defense response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within ethylene biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within leaf senescence IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within mRNA stabilization NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within programmed cell death IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    UBP1-associated protein 2A
    NP_001190109.1
    • UBP1-associated protein 2A (UBA2A); CONTAINS InterPro DOMAIN/s: RNA recognition motif, RNP-1 (InterPro:IPR000504), Nucleotide-binding, alpha-beta plait (InterPro:IPR012677); BEST Arabidopsis thaliana protein match is: RNA-binding (RRM/RBD/RNP motifs) family protein (TAIR:AT2G41060.2).
    NP_001190110.1
    • UBP1-associated protein 2A (UBA2A); CONTAINS InterPro DOMAIN/s: RNA recognition motif, RNP-1 (InterPro:IPR000504), Nucleotide-binding, alpha-beta plait (InterPro:IPR012677); BEST Arabidopsis thaliana protein match is: RNA-binding (RRM/RBD/RNP motifs) family protein (TAIR:AT2G41060.2).
    NP_001319772.1
    • UBP1-associated protein 2A (UBA2A); FUNCTIONS IN: RNA binding, AU-rich element binding; INVOLVED IN: in 6 processes; LOCATED IN: nucleus; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: RNA recognition motif, RNP-1 (InterPro:IPR000504), Nucleotide-binding, alpha-beta plait (InterPro:IPR012677); BEST Arabidopsis thaliana protein match is: RNA-binding (RRM/RBD/RNP motifs) family protein (TAIR:AT2G41060.2); Has 31201 Blast hits to 20858 proteins in 862 species: Archae - 47; Bacteria - 1378; Metazoa - 14800; Fungi - 3616; Plants - 4555; Viruses - 445; Other Eukaryotes - 6360 (source: NCBI BLink).
    NP_567042.1
    • UBP1-associated protein 2A (UBA2A); FUNCTIONS IN: RNA binding, AU-rich element binding; INVOLVED IN: in 6 processes; LOCATED IN: nucleus; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: RNA recognition motif, RNP-1 (InterPro:IPR000504), Nucleotide-binding, alpha-beta plait (InterPro:IPR012677); BEST Arabidopsis thaliana protein match is: RNA-binding (RRM/RBD/RNP motifs) family protein (TAIR:AT2G41060.2); Has 31187 Blast hits to 20847 proteins in 859 species: Archae - 47; Bacteria - 1373; Metazoa - 14793; Fungi - 3614; Plants - 4555; Viruses - 445; Other Eukaryotes - 6360 (source: NCBI BLink).
    NP_850711.1
    • UBP1-associated protein 2A (UBA2A); FUNCTIONS IN: RNA binding, AU-rich element binding; INVOLVED IN: in 6 processes; LOCATED IN: nucleus; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: RNA recognition motif, RNP-1 (InterPro:IPR000504), Nucleotide-binding, alpha-beta plait (InterPro:IPR012677); BEST Arabidopsis thaliana protein match is: RNA-binding (RRM/RBD/RNP motifs) family protein (TAIR:AT2G41060.2); Has 31187 Blast hits to 20847 proteins in 859 species: Archae - 47; Bacteria - 1373; Metazoa - 14793; Fungi - 3614; Plants - 4555; Viruses - 445; Other Eukaryotes - 6360 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      21048727..21052320 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_115545.4 → NP_567042.1  UBP1-associated protein 2A [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      C0Z2A5, Q94B29, Q9LES2
      UniProtKB/TrEMBL
      A0A178VCS6, A0A5S9XLK2
      Conserved Domains (3) summary
      TIGR01628
      Location:136 → 347
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      pfam09606
      Location:361 → 465
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cl17169
      Location:140 → 215
      RRM_SF; RNA recognition motif (RRM) superfamily

    2. NM_180380.3 → NP_850711.1  UBP1-associated protein 2A [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      C0Z2A5, Q94B29, Q9LES2
      UniProtKB/TrEMBL
      A0A178VCS6, A0A5S9XLK2
      Conserved Domains (3) summary
      TIGR01628
      Location:136 → 347
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      pfam09606
      Location:361 → 465
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cl17169
      Location:140 → 215
      RRM_SF; RNA recognition motif (RRM) superfamily

    3. NM_001203180.2 → NP_001190109.1  UBP1-associated protein 2A [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      C0Z2A5, Q94B29, Q9LES2
      UniProtKB/TrEMBL
      A0A178VCS6, A0A5S9XLK2
      Conserved Domains (3) summary
      TIGR01628
      Location:136 → 347
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      pfam09606
      Location:361 → 465
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cl17169
      Location:140 → 215
      RRM_SF; RNA recognition motif (RRM) superfamily

    4. NM_001339831.1 → NP_001325969.1  UBP1-associated protein 2A [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      C0Z2A5, Q94B29, Q9LES2
      UniProtKB/TrEMBL
      A0A178VCS6, A0A5S9XLK2
      Conserved Domains (3) summary
      TIGR01628
      Location:136 → 347
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      pfam09606
      Location:361 → 465
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cl17169
      Location:140 → 215
      RRM_SF; RNA recognition motif (RRM) superfamily

    5. NM_001339830.1 → NP_001325970.1  UBP1-associated protein 2A [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      C0Z2A5, Q94B29, Q9LES2
      UniProtKB/TrEMBL
      A0A178VCS6, A0A5S9XLK2
      Conserved Domains (3) summary
      TIGR01628
      Location:136 → 347
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      pfam09606
      Location:361 → 465
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cl17169
      Location:140 → 215
      RRM_SF; RNA recognition motif (RRM) superfamily

    6. NM_001339829.1 → NP_001325971.1  UBP1-associated protein 2A [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      C0Z2A5, Q94B29, Q9LES2
      UniProtKB/TrEMBL
      A0A178VCS6, A0A5S9XLK2
      Conserved Domains (3) summary
      TIGR01628
      Location:136 → 347
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      pfam09606
      Location:361 → 465
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cl17169
      Location:140 → 215
      RRM_SF; RNA recognition motif (RRM) superfamily

    7. NM_180379.4 → NP_850710.1  UBP1-associated protein 2A [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      C0Z2A5, Q94B29, Q9LES2
      UniProtKB/TrEMBL
      A0A178VCS6, A0A5S9XLK2
      Conserved Domains (3) summary
      TIGR01628
      Location:136 → 347
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      pfam09606
      Location:361 → 465
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cl17169
      Location:140 → 215
      RRM_SF; RNA recognition motif (RRM) superfamily

    8. NM_001203181.1 → NP_001190110.1  UBP1-associated protein 2A [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      C0Z2A5, Q94B29, Q9LES2
      UniProtKB/TrEMBL
      A0A178VCS6, A0A5S9XLK2
      Conserved Domains (3) summary
      TIGR01628
      Location:136 → 347
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      pfam09606
      Location:361 → 465
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cl17169
      Location:140 → 215
      RRM_SF; RNA recognition motif (RRM) superfamily

    9. NM_001339826.1 → NP_001325972.1  UBP1-associated protein 2A [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      C0Z2A5, Q94B29, Q9LES2
      UniProtKB/TrEMBL
      A0A178VCS6, A0A5S9XLK2
      Conserved Domains (3) summary
      TIGR01628
      Location:136 → 347
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      pfam09606
      Location:361 → 465
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cl17169
      Location:140 → 215
      RRM_SF; RNA recognition motif (RRM) superfamily

    10. NM_001339828.1 → NP_001319772.1  UBP1-associated protein 2A [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      C0Z2A5, Q94B29, Q9LES2
      UniProtKB/TrEMBL
      A0A178VCS6, A0A5S9XLK2
      Conserved Domains (3) summary
      TIGR01628
      Location:136 → 347
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      pfam09606
      Location:361 → 465
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cl17169
      Location:140 → 215
      RRM_SF; RNA recognition motif (RRM) superfamily

    11. NM_001339827.1 → NP_001325973.1  UBP1-associated protein 2A [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      C0Z2A5, Q94B29, Q9LES2
      UniProtKB/TrEMBL
      A0A178VCS6, A0A5S9XLK2
      Conserved Domains (3) summary
      TIGR01628
      Location:136 → 347
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      pfam09606
      Location:361 → 465
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cl17169
      Location:140 → 215
      RRM_SF; RNA recognition motif (RRM) superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LES2.1

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