ybeY endoribonuclease YbeY [Escherichia coli str. K-12 substr. MG1655] - Gene

Summary

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Official Symbol: ybeY
Official Full Name: endoribonuclease YbeY
Primary source: ECOCYC:G6362
Locus tag: b0659
See related: ASAP:ABE-0002255
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage: Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as: ECK0651
Summary: AFMB Structural Genomics target Number 122 (http://afmb.cnrs-mrs.fr/article171.html). [More information is available at EcoGene: EG13655]. YbeY shows similarity to metal-dependent hydrolases. [More information is available at EcoCyc: G6362].
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Genomic context

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Sequence:: NC_000913.3 (691874..692341, complement)

NC_000913.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_000913.3

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

YbeY binds to Era and is involved in the 3'-end processing of 16S rRNA
Title: Elevated Levels of Era GTPase Improve Growth, 16S rRNA Processing, and 70S Ribosome Assembly of Escherichia coli Lacking Highly Conserved Multifunctional YbeY Endoribonuclease.
This work provides the first evidence that YbeY is recruited to the ribosome through interaction with proteins involved in ribosome biogenesis (i.e., ribosomal protein S11, Era).
Title: Identification of YbeY-Protein Interactions Involved in 16S rRNA Maturation and Stress Regulation in Escherichia coli.
This observation suggests that the function of HuYbeY in human cells is likely regulated through specific interactions with partner proteins similarly to the way YbeY is regulated in bacteria.
Title: C21orf57 is a human homologue of bacterial YbeY proteins.
evidence which tie YbeY to the transcription antitermination process
Title: The Escherichia coli translation-associated heat shock protein YbeY is involved in rRNA transcription antitermination.
Deletion of ybeY strongly affects the maturation of rRNA, and causes striking defects in ribosome function including decreased ribosome activity, reduced translational fidelity and altered translation initiation factor binding.
Title: Role of Escherichia coli YbeY, a highly conserved protein, in rRNA processing.
Data show that the in vitro activity of the translation machinery of ybeY deletion mutants is significantly lower than that of the wild type.
Title: The heat shock protein YbeY is required for optimal activity of the 30S ribosomal subunit.
The authors provide evidence that YbeY, a conserved heat shock protein with unknown function, is involved in the translation process.
Title: YbeY, a heat shock protein involved in translation in Escherichia coli.
ybeY protein from Escherichia coli is a metalloprotein
Title: The ybeY protein from Escherichia coli is a metalloprotein.

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General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by EcoCyc

Function	Evidence Code	Pubs
enables RNA endonuclease activity	IEA Inferred from Electronic Annotation more info
enables RNA endonuclease activity, producing 3'-phosphomonoesters	IDA Inferred from Direct Assay more info	PubMed
enables endonuclease activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables metalloendopeptidase activity	IEA Inferred from Electronic Annotation more info
enables nickel cation binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within maturation of SSU-rRNA	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in rRNA processing	IEA Inferred from Electronic Annotation more info
involved_in rRNA processing	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to heat	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to heat	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within ribosomal small subunit biogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ribosome biogenesis	IEA Inferred from Electronic Annotation more info
involved_in ribosome biogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within transcription antitermination	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within translation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: endoribonuclease YbeY

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_000913.3 Reference assembly

Range

691874..692341 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NP_415192.1 endoribonuclease YbeY [Escherichia coli str. K-12 substr. MG1655]

See identical proteins and their annotated locations for NP_415192.1

Status: PROVISIONAL

UniProtKB/TrEMBL

W1EUK5

Conserved Domains (1) summary

PRK00016
Location:7 → 154

PRK00016; metal-binding heat shock protein; Provisional