U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    ynaI small conductance mechanosensitive channel YnaI [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945898, updated on 17-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    ynaI
    Official Full Name
    small conductance mechanosensitive channel YnaI
    Primary source
    ECOCYC:G6666
    Locus tag
    b1330
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1327
    Summary
    EvgAS regulon. mscS, kefA, yjeP, ybiO, ybdG and ynaI are paralogs. [More information is available at EcoGene: EG13924]. YnaI is a putative member of the small mechanosensitive ion channel MscS family. [More information is available at EcoCyc: G6666].
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Sequence:
    NC_000913.3 (1394891..1395922, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene DNA-binding transcriptional repressor PgrR Neighboring gene murein tripeptide ABC transporter periplasmic binding protein Neighboring gene IS5 family transposase and trans-activator Neighboring gene DUF2534 domain-containing protein YnaJ

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The Structure of YnaI Implies Structural and Mechanistic Conservation in the MscS Family of Mechanosensitive Channels. Böttcher B, et al. Structure, 2015 Sep 1. PMID 26256535, Free PMC Article
    2. The MscS-like channel YnaI has a gating mechanism based on flexible pore helices. Flegler VJ, et al. Proc Natl Acad Sci U S A, 2020 Nov 17. PMID 33148804, Free PMC Article
    3. Identification and mapping of self-assembling protein domains encoded by the Escherichia coli K-12 genome by use of lambda repressor fusions. Mariño-Ramírez L, et al. J Bacteriol, 2004 Mar. PMID 14973045, Free PMC Article
    4. Analysis of the kefA2 mutation suggests that KefA is a cation-specific channel involved in osmotic adaptation in Escherichia coli. McLaggan D, et al. Mol Microbiol, 2002 Jan. PMID 11985727
    5. Protection of Escherichia coli cells against extreme turgor by activation of MscS and MscL mechanosensitive channels: identification of genes required for MscS activity. Levina N, et al. EMBO J, 1999 Apr 1. PMID 10202137, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The MscS-like channel YnaI has a gating mechanism based on flexible pore helices.
      Title: The MscS-like channel YnaI has a gating mechanism based on flexible pore helices.
    2. High level expression of YnaI proteins from a multicopy plasmid in the Delta7 strain (MJFGH) leads to substantial protection against hypoosmotic shock.
      Title: Characterization of three novel mechanosensitive channel activities in Escherichia coli.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables mechanosensitive monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mechanosensitive monoatomic ion channel activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to osmotic stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    small conductance mechanosensitive channel YnaI

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1394891..1395922 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415846.1 small conductance mechanosensitive channel YnaI [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415846.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A377D1I3
      Conserved Domains (1) summary
      pfam00924
      Location:121 → 323
      MS_channel; Mechanosensitive ion channel
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.