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    rlmG 23S rRNA m(2)G1835 methyltransferase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947589, updated on 3-Dec-2024

    Summary

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    Official Symbol
    rlmG
    Official Full Name
    23S rRNA m(2)G1835 methyltransferase
    Primary source
    ECOCYC:G7603
    Locus tag
    b3084
    See related
    ASAP:ABE-0010133
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3074; ygjO
    Summary
    RlmG methyltransferase mutants have a disadvantage in competitve growth cultures with wild type (Sergiev, 2006). [More information is available at EcoGene: EG12726]. RlmG is the methyltransferase responsible for methylation of 23S rRNA at the N2 position of the G1835 nucleotide. [More information is available at EcoCyc: G7603].
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    Genomic context

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    Sequence:
    NC_000913.3 (3234739..3235875, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene 2,4-dienoyl-CoA reductase Neighboring gene antitoxin/DNA-binding transcriptional repressor HigA Neighboring gene ribosome-dependent mRNA interferase toxin HigB Neighboring gene putative metal-dependent hydrolase Neighboring gene DUF218 domain-containing protein YgjQ

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of Escherichia coli m2G methyltransferases: II. The ygjO gene encodes a methyltransferase specific for G1835 of the 23 S rRNA. Sergiev PV, et al. J Mol Biol, 2006 Nov 17. PMID 17010380
    2. Phylogenomic analysis of 16S rRNA:(guanine-N2) methyltransferases suggests new family members and reveals highly conserved motifs and a domain structure similar to other nucleic acid amino-methyltransferases. Bujnicki JM. FASEB J, 2000 Nov. PMID 11053259
    3. RNA:(guanine-N2) methyltransferases RsmC/RsmD and their homologs revisited--bioinformatic analysis and prediction of the active site based on the uncharacterized Mj0882 protein structure. Bujnicki JM, et al. BMC Bioinformatics, 2002 Apr 3. PMID 11929612, Free PMC Article
    4. Role of 16S ribosomal RNA methylations in translation initiation in Escherichia coli. Das G, et al. EMBO J, 2008 Mar 19. PMID 18288206, Free PMC Article
    5. Comparative genomics and evolution of proteins involved in RNA metabolism. Anantharaman V, et al. Nucleic Acids Res, 2002 Apr 1. PMID 11917006, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables 23S rRNA (guanine(1835)-N(2))-methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 23S rRNA (guanine(1835)-N(2))-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables N-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables S-adenosylmethionine-dependent methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables rRNA (guanine-N2-)-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables rRNA (guanine-N2-)-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in rRNA base methylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within rRNA base methylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in rRNA methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    23S rRNA m(2)G1835 methyltransferase
    NP_417555.4

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3234739..3235875 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417555.4 23S rRNA m(2)G1835 methyltransferase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417555.4

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A7D7KBD9
      Conserved Domains (1) summary
      PRK15001
      Location:1 → 378
      PRK15001; 23S rRNA (guanine(1835)-N(2))-methyltransferase RlmG
    Nucleotide Protein
    Heading Accession and Version

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