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    nrdG anaerobic ribonucleoside-triphosphate reductase activating protein [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948757, updated on 3-Dec-2024

    Summary

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    Official Symbol
    nrdG
    Official Full Name
    anaerobic ribonucleoside-triphosphate reductase activating protein
    Primary source
    ECOCYC:G812
    Locus tag
    b4237
    See related
    ASAP:ABE-0013860
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK4232; yjgE
    Summary
    FNR regulon. [More information is available at EcoGene: EG12523]. An nrdG null mutant does not grow under entirely anaerobic conditions, but grows under aerobic or microaerophilic conditions due to the activity of NrdA and/or NrdB . [More information is available at EcoCyc: G812].
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    Genomic context

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    Sequence:
    NC_000913.3 (4459900..4460364, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene metalloprotease subunit TldE Neighboring gene pseudo Neighboring gene anaerobic ribonucleoside-triphosphate reductase Neighboring gene trehalose-6-phosphate hydrolase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular properties of pyruvate formate-lyase activating enzyme. Wong KK, et al. Biochemistry, 1993 Dec 28. PMID 8260492
    2. An iron-sulfur center and a free radical in the active anaerobic ribonucleotide reductase of Escherichia coli. Mulliez E, et al. J Biol Chem, 1993 Feb 5. PMID 8381402
    3. The activating component of the anaerobic ribonucleotide reductase from Escherichia coli. An iron-sulfur center with only three cysteines. Tamarit J, et al. J Biol Chem, 2000 May 26. PMID 10821845
    4. Deoxyribonucleotide synthesis in anaerobic microorganisms: the class III ribonucleotide reductase. Fontecave M, et al. Prog Nucleic Acid Res Mol Biol, 2002. PMID 12206460
    5. Fumarate and nitrate reduction (FNR) dependent activation of the Escherichia coli anaerobic ribonucleotide reductase nrdDG promoter. Roca I, et al. Int Microbiol, 2008 Mar. PMID 18683632

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables 4 iron, 4 sulfur cluster binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 4 iron, 4 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables [formate-C-acetyltransferase]-activating enzyme activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron-sulfur cluster binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    contributes_to ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in 2'-deoxyribonucleotide biosynthetic process NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within nucleobase-containing small molecule interconversion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nucleobase-containing small molecule interconversion NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of anaerobic ribonucleoside-triphosphate reductase complex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    anaerobic ribonucleoside-triphosphate reductase activating protein

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      4459900..4460364 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418658.1 anaerobic ribonucleoside-triphosphate reductase activating protein [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418658.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8T6A891
      Conserved Domains (1) summary
      PRK11121
      Location:1 → 154
      nrdG; anaerobic ribonucleoside-triphosphate reductase-activating protein
    Nucleotide Protein
    Heading Accession and Version

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