U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    lolE lipoprotein release complex - inner membrane subunit [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945665, updated on 3-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    lolE
    Official Full Name
    lipoprotein release complex - inner membrane subunit
    Primary source
    ECOCYC:G6575
    Locus tag
    b1118
    See related
    ASAP:ABE-0003776
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1104; ycfW
    Summary
    LolE is a membrane component of the LolCDE lipoprotein export ABC transporter. [More information is available at EcoCyc: G6575].
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Sequence:
    NC_000913.3 (1177320..1178564)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene inner membrane protein YcfT Neighboring gene lipoprotein release complex - inner membrane subunit Neighboring gene lipoprotein release complex - ATP binding subunit Neighboring gene N-acetyl-D-glucosamine kinase Neighboring gene CobB-S;protein-lysine deacetylase/desuccinylase/lipoamidase

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Transcriptional Responses of Escherichia coli to a Small-Molecule Inhibitor of LolCDE, an Essential Component of the Lipoprotein Transport Pathway. Lorenz C, et al. J Bacteriol, 2016 Dec 1. PMID 27645386, Free PMC Article
    2. A single amino acid determinant of the membrane localization of lipoproteins in E. coli. Yamaguchi K, et al. Cell, 1988 May 6. PMID 3284654
    3. Biogenesis of the gram-negative bacterial envelope. Duong F, et al. Cell, 1997 Nov 28. PMID 9393850
    4. A new ABC transporter mediating the detachment of lipid-modified proteins from membranes. Yakushi T, et al. Nat Cell Biol, 2000 Apr. PMID 10783239
    5. Disruption of lolCDE, encoding an ATP-binding cassette transporter, is lethal for Escherichia coli and prevents release of lipoproteins from the inner membrane. Narita S, et al. J Bacteriol, 2002 Mar. PMID 11844772, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Structural basis for bacterial lipoprotein relocation by the transporter LolCDE.
      Title: Structural basis for bacterial lipoprotein relocation by the transporter LolCDE.
    2. Inhibition of LolCDE leads to significant inhibition of growth and lipoprotein transport.
      Title: Transcriptional Responses of Escherichia coli to a Small-Molecule Inhibitor of LolCDE, an Essential Component of the Lipoprotein Transport Pathway.
    3. These results indicate that the affinity of LolCDE for apolipoprotein is very low, and therefore, overexpression of LolCDE is required for its release and sorting to the outer membrane.
      Title: Overexpression of LolCDE allows deletion of the Escherichia coli gene encoding apolipoprotein N-acyltransferase.
    4. N-terminus verified by Edman degradation on mature peptide
      Title: A new ABC transporter mediating the detachment of lipid-modified proteins from membranes.
    5. suppressor mutations of the lolE gene that correct the growth defect caused by the LolD mutations were mainly located in the cytoplasmic loop
      Title: Genetic analysis of the mode of interplay between an ATPase subunit and membrane subunits of the lipoprotein-releasing ATP-binding cassette transporter LolCDE.
    6. Liganded LolCDE thus reveals molecular events brought about through ATP binding and hydrolysis, LolCDE is the first example of an ABC transporter purified with tightly bound native substrates.
      Title: A novel ligand bound ABC transporter, LolCDE, provides insights into the molecular mechanisms underlying membrane detachment of bacterial lipoproteins.
    Submit: New GeneRIF Correction

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables lipoprotein releasing activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables lipoprotein releasing activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in lipoprotein localization to outer membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within lipoprotein localization to outer membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in lipoprotein localization to outer membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in lipoprotein localization to outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within lipoprotein localization to outer membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lipoprotein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of ATP-binding cassette (ABC) transporter complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    part_of plasma membrane protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of plasma membrane protein complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    lipoprotein release complex - inner membrane subunit

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1177320..1178564
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415636.1 lipoprotein release complex - inner membrane subunit [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415636.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A0A0G274, A0A0H3ET60, A0A7U9J0F3, A0AAN3UZK3
      Conserved Domains (1) summary
      PRK11146
      Location:3 → 414
      PRK11146; lipoprotein-releasing ABC transporter permease subunit LolE
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.