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    mlaC intermembrane phospholipid transport system - periplasmic binding protein [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947710, updated on 3-Dec-2024

    Summary

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    Official Symbol
    mlaC
    Official Full Name
    intermembrane phospholipid transport system - periplasmic binding protein
    Primary source
    ECOCYC:G7659
    Locus tag
    b3192
    See related
    ASAP:ABE-0010489
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3181; yrbC
    Summary
    The first 21 aa are predicted to be a Type I signal peptide. [More information is available at EcoGene: EG12798].
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    Genomic context

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    Sequence:
    NC_000913.3 (3337256..3337891, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene UDP-N-acetylglucosamine 1-carboxyvinyltransferase Neighboring gene acid stress protein IbaG Neighboring gene intermembrane phospholipid transport system protein MlaB Neighboring gene intermembrane phospholipid transport system, substrate binding protein MlaD Neighboring gene intermembrane phospholipid transport system, integral membrane subunit MlaE

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Protein-protein interactions in the Mla lipid transport system probed by computational structure prediction and deep mutational scanning. MacRae MR, et al. J Biol Chem, 2023 Jun. PMID 37100290, Free PMC Article
    2. Structure of the MlaC-MlaD complex reveals molecular basis of periplasmic phospholipid transport. Wotherspoon P, et al. Nat Commun, 2024 Jul 30. PMID 39080293, Free PMC Article
    3. Proteome analysis of Escherichia coli using high-performance liquid chromatography and Fourier transform ion cyclotron resonance mass spectrometry. Ihling C, et al. Proteomics, 2005 May. PMID 15852340
    4. Architectures of Lipid Transport Systems for the Bacterial Outer Membrane. Ekiert DC, et al. Cell, 2017 Apr 6. PMID 28388411, Free PMC Article
    5. Getting in or out: early segregation between importers and exporters in the evolution of ATP-binding cassette (ABC) transporters. Saurin W, et al. J Mol Evol, 1999 Jan. PMID 9873074

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Structure of the MlaC-MlaD complex reveals molecular basis of periplasmic phospholipid transport.
      Title: Structure of the MlaC-MlaD complex reveals molecular basis of periplasmic phospholipid transport.
    2. Protein-protein interactions in the Mla lipid transport system probed by computational structure prediction and deep mutational scanning.
      Title: Protein-protein interactions in the Mla lipid transport system probed by computational structure prediction and deep mutational scanning.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within intermembrane phospholipid transfer IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within phospholipid transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in outer membrane-bounded periplasmic space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in periplasmic space IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    intermembrane phospholipid transport system - periplasmic binding protein

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3337256..3337891 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417659.1 intermembrane phospholipid transport system - periplasmic binding protein [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417659.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A6L7CE02
      Conserved Domains (1) summary
      PRK15117
      Location:1 → 211
      PRK15117; phospholipid-binding protein MlaC
    Nucleotide Protein
    Heading Accession and Version

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