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    nanK N-acetylmannosamine kinase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947757, updated on 3-Dec-2024

    Summary

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    Official Symbol
    nanK
    Official Full Name
    N-acetylmannosamine kinase
    Primary source
    ECOCYC:G7676
    Locus tag
    b3222
    See related
    ASAP:ABE-0010571
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3211; yhcI
    Summary
    NanK has low level glucokinase activity. [More information is available at EcoGene: EG12815]. NanK belongs to the family of ROK sugar kinases and was shown to have both N-acetylmannosamine kinase and rudimentary glucokinase activity in vitro . [More information is available at EcoCyc: G7676].
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    Genomic context

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    Sequence:
    NC_000913.3 (3369475..3370350, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene DUF1120 domain-containing protein YhcF Neighboring gene DUF1016 domain-containing protein YhcG Neighboring gene N-acetylneuraminate anomerase Neighboring gene putative N-acetylmannosamine-6-phosphate 2-epimerase Neighboring gene N-acetylneuraminate:H(+) symporter Neighboring gene N-acetylneuraminate lyase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Purification and properties of N-acetylmannosamine kinase from Salmonella typhimurium. Banerjee S, et al. Eur J Biochem, 1969 Mar. PMID 4889177
    2. Identifying latent enzyme activities: substrate ambiguity within modern bacterial sugar kinases. Miller BG, et al. Biochemistry, 2004 Jun 1. PMID 15157072
    3. Complete nucleotide sequence of the E. coli N-acetylneuraminate lyase. Ohta Y, et al. Nucleic Acids Res, 1985 Dec 20. PMID 3909108, Free PMC Article
    4. Regulation of sialic acid catabolism by the DNA binding protein NanR in Escherichia coli. Kalivoda KA, et al. J Bacteriol, 2003 Aug. PMID 12897000, Free PMC Article
    5. Diversity of microbial sialic acid metabolism. Vimr ER, et al. Microbiol Mol Biol Rev, 2004 Mar. PMID 15007099, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables N-acylmannosamine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables N-acylmannosamine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables N-acylmannosamine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA damage response IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in N-acetylneuraminate catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in N-acetylneuraminate catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in N-acetylneuraminate catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in carbohydrate phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    N-acetylmannosamine kinase
    NP_417689.4

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3369475..3370350 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417689.4 N-acetylmannosamine kinase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417689.4

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8S7EFJ5
      Conserved Domains (1) summary
      PRK05082
      Location:1 → 276
      PRK05082; N-acetylmannosamine kinase; Provisional
    Nucleotide Protein
    Heading Accession and Version

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