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    dcuR DNA-binding transcriptional activator DcuR [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948640, updated on 3-Dec-2024

    Summary

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    Official Symbol
    dcuR
    Official Full Name
    DNA-binding transcriptional activator DcuR
    Primary source
    ECOCYC:G7826
    Locus tag
    b4124
    See related
    ASAP:ABE-0013507
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK4117; yjdG
    Summary
    dcuSR operon is repressed by nitrate via the NarXL system. [More information is available at EcoGene: EG12464]. [More information is available at EcoCyc: G7826].
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    Genomic context

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    Sequence:
    NC_000913.3 (4349315..4350034, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene fumarase B Neighboring gene anaerobic C4-dicarboxylate transporter DcuB Neighboring gene sensor histidine kinase DcuS Neighboring gene PF06902 family protein YjdI Neighboring gene putative N-acetyltransferase YjdJ

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Tight Complex Formation of the Fumarate Sensing DcuS-DcuR Two-Component System at the Membrane and Target Promoter Search by Free DcuR Diffusion. Gencheva S, et al. mSphere, 2022 Aug 31. PMID 35862816, Free PMC Article
    2. Function of DcuS from Escherichia coli as a fumarate-stimulated histidine protein kinase in vitro. Janausch IG, et al. J Biol Chem, 2002 Oct 18. PMID 12167640
    3. Phosphorylation and DNA binding of the regulator DcuR of the fumarate-responsive two-component system DcuSR of Escherichia coli. Janausch IG, et al. Microbiology (Reading), 2004 Apr. PMID 15073297
    4. Polar localization of a tripartite complex of the two-component system DcuS/DcuR and the transporter DctA in Escherichia coli depends on the sensor kinase DcuS. Scheu PD, et al. PLoS One, 2014. PMID 25549248, Free PMC Article
    5. Fumarate regulation of gene expression in Escherichia coli by the DcuSR (dcuSR genes) two-component regulatory system. Zientz E, et al. J Bacteriol, 1998 Oct. PMID 9765574, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Regulation of Aerobic Succinate Transporter dctA of E. coli by cAMP-CRP, DcuS-DcuR, and EIIAGlc: Succinate as a Carbon Substrate and Signaling Molecule.
      Title: Regulation of Aerobic Succinate Transporter dctA of E. coli by cAMP-CRP, DcuS-DcuR, and EIIAGlc: Succinate as a Carbon Substrate and Signaling Molecule.
    2. Tight Complex Formation of the Fumarate Sensing DcuS-DcuR Two-Component System at the Membrane and Target Promoter Search by Free DcuR Diffusion.
      Title: Tight Complex Formation of the Fumarate Sensing DcuS-DcuR Two-Component System at the Membrane and Target Promoter Search by Free DcuR Diffusion.
    3. DcuS is required for location of DctA and DcuR at the poles and formation of tripartite DctA/DcuS/DcuR sensor/regulator complexes.
      Title: Polar localization of a tripartite complex of the two-component system DcuS/DcuR and the transporter DctA in Escherichia coli depends on the sensor kinase DcuS.
    4. DcuS/DcuR modulating citA and citB expression.
      Title: CitA/CitB two-component system regulating citrate fermentation in Escherichia coli and its relation to the DcuS/DcuR system in vivo.
    5. The transcription of structural genes is activated by the DcuS-DcuR two-component system in response to fumarate or its dicarboxylate precursors.
      Title: Hierarchical control of anaerobic gene expression in Escherichia coli K-12: the nitrate-responsive NarX-NarL regulatory system represses synthesis of the fumarate-responsive DcuS-DcuR regulatory system.
    6. Study analyzed promoters of the dcuS-R operon to elucidate the transcriptional regulation system and found a new internal promoter within the dcuS gene that is regulated by the transcriptional regulator, CRP-cAMP, in both aerobic and anaerobic conditions.
      Title: Expression of Escherichia coli DcuS-R two-component regulatory system is regulated by the secondary internal promoter which is activated by CRP-cAMP.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphorelay response regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA-templated transcription IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within phosphorelay signal transduction system IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in phosphorelay signal transduction system IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within positive regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    DNA-binding transcriptional activator DcuR

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      4349315..4350034 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418548.1 DNA-binding transcriptional activator DcuR [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418548.1

      Status: PROVISIONAL

      Conserved Domains (1) summary
      PRK10430
      Location:1 → 239
      PRK10430; two-component system response regulator DcuR
    Nucleotide Protein
    Heading Accession and Version

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