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    ilvM acetolactate synthase II subunit IlvM [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948279, updated on 3-Dec-2024

    Summary

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    Official Symbol
    ilvM
    Official Full Name
    acetolactate synthase II subunit IlvM
    Primary source
    ECOCYC:EG10501
    Locus tag
    b3769
    See related
    ASAP:ABE-0012313
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3761
    Summary
    The Salmonella IlvM N-terminal sequence (Schloss et al., 1985) and spacing to the RBS indicate the first ATG is used. [More information is available at EcoGene: EG10501]. Acetohydroxyacid synthase II (AHAS II) catalyzes the biosynthesis of -aceto--hydroxybutyrate and -acetolactate. [More information is available at EcoCyc: EG10501].
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    Genomic context

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    Sequence:
    NC_000913.3 (3952201..3952464)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene ilvXGMEDA operon leader peptide Neighboring gene uncharacterized protein IlvX Neighboring gene pseudo Neighboring gene branched-chain-amino-acid aminotransferase Neighboring gene dihydroxy-acid dehydratase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Analysis and comparison of the internal promoter, pE, of the ilvGMEDA operons from Escherichia coli K-12 and Salmonella typhimurium. Lopes JM, et al. Nucleic Acids Res, 1986 Mar 25. PMID 3008097, Free PMC Article
    2. Binding and activation of thiamin diphosphate in acetohydroxyacid synthase. Bar-Ilan A, et al. Biochemistry, 2001 Oct 2. PMID 11570896
    3. Homology modeling of the structure of bacterial acetohydroxy acid synthase and examination of the active site by site-directed mutagenesis. Ibdah M, et al. Biochemistry, 1996 Dec 17. PMID 8973202
    4. Examination of the internal promoter, PE, in the ilvGMEDA operon of E. coli K-12. Wek RC, et al. Nucleic Acids Res, 1986 Mar 25. PMID 2421252, Free PMC Article
    5. Effects of deletion and insertion mutations in the ilvM gene of Escherichia coli. Lu MF, et al. J Bacteriol, 1987 Feb. PMID 3027038, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ilvM is able to activate the large subunits of all three acetolactate synthase I, II and III isozymes.
      Title: Interactions between large and small subunits of different acetohydroxyacid synthase isozymes of Escherichia coli.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables acetolactate synthase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables acetolactate synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-valine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within amino acid biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in amino acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in branched-chain amino acid biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in branched-chain amino acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in isoleucine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of acetolactate synthase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    acetolactate synthase II subunit IlvM
    NP_418217.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3952201..3952464
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418217.1 acetolactate synthase II subunit IlvM [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418217.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8S0FHH5
      Conserved Domains (1) summary
      PRK11152
      Location:1 → 76
      ilvM; acetolactate synthase 2 small subunit
    Nucleotide Protein
    Heading Accession and Version

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