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    dcm DNA-cytosine methyltransferase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946479, updated on 17-Dec-2024

    Summary

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    Official Symbol
    dcm
    Official Full Name
    DNA-cytosine methyltransferase
    Primary source
    ECOCYC:EG10211
    Locus tag
    b1961
    See related
    ASAP:ABE-0006509
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1959; mec
    Summary
    Dcm is a DNA cytosine methyltransferase that preferentially methylates sites of sequence 5' C-MeC-T 3' . [More information is available at EcoCyc: EG10211].
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    Genomic context

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    Sequence:
    NC_000913.3 (2030899..2032317, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene DUF808 domain-containing inner membrane protein YedI Neighboring gene putative transporter YedA Neighboring gene DNA mismatch endonuclease Vsr Neighboring gene putative HD superfamily phosphohydrolase YedJ Neighboring gene cell division protein DrpB

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Survival and mutagenic effects of 5-azacytidine in Escherichia coli. Lal D, et al. Mutat Res, 1988 May. PMID 2452347
    2. Expression of the cloned coliphage T3 S-adenosylmethionine hydrolase gene inhibits DNA methylation and polyamine biosynthesis in Escherichia coli. Hughes JA, et al. J Bacteriol, 1987 Aug. PMID 3301808, Free PMC Article
    3. Very short patch mismatch repair activity associated with gene dcm is not conferred by a plasmid coding for EcoRII methylase. Lieb M, et al. J Bacteriol, 1988 Oct. PMID 3049557, Free PMC Article
    4. Genetic expression and gyrase dependence of methylated and undermethylated DNA in Escherichia coli. Gomez-Eichelmann MC, et al. Biochim Biophys Acta, 1985 Jul 24. PMID 2990558
    5. Mismatch repair mutations of Escherichia coli K12 enhance transposon excision. Lundblad V, et al. Genetics, 1985 Jan. PMID 2981756, Free PMC Article

    See all (62) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables DNA (cytosine-5-)-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA (cytosine-5-)-methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA (cytosine-5-)-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA (cytosine-5-)-methyltransferase activity, acting on CpN substrates IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA (cytosine-5-)-methyltransferase activity, acting on CpNpG substrates IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA restriction-modification system IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of gene expression via chromosomal CpG island methylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    DNA-cytosine methyltransferase
    NP_416470.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2030899..2032317 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416470.1 DNA-cytosine methyltransferase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416470.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376M657
      Conserved Domains (1) summary
      PRK10458
      Location:1 → 465
      PRK10458; DNA cytosine methylase; Provisional
    Nucleotide Protein
    Heading Accession and Version

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