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    TCF7 transcription factor 7 [ Homo sapiens (human) ]

    Gene ID: 6932, updated on 10-Dec-2024

    Summary

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    Official Symbol
    TCF7provided by HGNC
    Official Full Name
    transcription factor 7provided by HGNC
    Primary source
    HGNC:HGNC:11639
    See related
    Ensembl:ENSG00000081059 MIM:189908; AllianceGenome:HGNC:11639
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TCF-1
    Summary
    This gene encodes a member of the T-cell factor/lymphoid enhancer-binding factor family of high mobility group (HMG) box transcriptional activators. This gene is expressed predominantly in T-cells and plays a critical role in natural killer cell and innate lymphoid cell development. The encoded protein forms a complex with beta-catenin and activates transcription through a Wnt/beta-catenin signaling pathway. Mice with a knockout of this gene are viable and fertile, but display a block in T-lymphocyte differentiation. Alternative splicing results in multiple transcript variants. Naturally-occurring isoforms lacking the N-terminal beta-catenin interaction domain may act as dominant negative regulators of Wnt signaling. [provided by RefSeq, Oct 2016]
    Expression
    Broad expression in lymph node (RPKM 9.2), appendix (RPKM 6.3) and 14 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See TCF7 in Genome Data Viewer
    Location:
    5q31.1
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (134108218..134148210)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (134630059..134671840)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (133450372..133483901)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105379183 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23112 Neighboring gene MPRA-validated peak5471 silencer Neighboring gene voltage dependent anion channel 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23113 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23114 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16349 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16350 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16351 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23115 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23116 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23117 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23118 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23119 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23120 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:133382518-133383158 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:133383159-133383798 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:133385203-133385778 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr5:133387505-133388080 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:133394172-133394770 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:133394771-133395367 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16352 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16353 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23121 Neighboring gene short transmembrane mitochondrial protein 1-like Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:133422388-133422888 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:133422889-133423389 Neighboring gene Sharpr-MPRA regulatory region 10905 Neighboring gene Sharpr-MPRA regulatory region 12956 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23122 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23123 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:133437181-133438148 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:133438510-133439380 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23125 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:133441120-133441988 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:133442973-133443520 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16354 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23126 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23127 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16355 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:133457701-133458202 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23128 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:133464814-133465636 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:133465637-133466458 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23129 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23131 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23130 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23132 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:133475053-133476030 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23133 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23134 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23135 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23136 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16356 Neighboring gene S-phase kinase associated protein 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:133513545-133514059 Neighboring gene protein phosphatase 2 catalytic subunit alpha Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23137 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23138 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23139 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:133561503-133562022 Neighboring gene microRNA 3661

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Transcriptional Regulatory Network for the Development of Innate Lymphoid Cells. Zhong C, et al. Mediators Inflamm, 2015. PMID 26379372, Free PMC Article
    2. Clinical Significance of Transcription Factor 7 (TCF7) as a Prognostic Factor in Gastric Cancer. Xu X, et al. Med Sci Monit, 2019 May 28. PMID 31133633, Free PMC Article
    3. A WNT/p21 circuit directed by the C-clamp, a sequence-specific DNA binding domain in TCFs. Hoverter NP, et al. Mol Cell Biol, 2012 Sep. PMID 22778133, Free PMC Article
    4. Transcriptional regulation of innate and adaptive lymphocyte lineages. De Obaldia ME, et al. Annu Rev Immunol, 2015. PMID 25665079
    5. Transcription factor 7 functions as an unfavorable prognostic marker of glioblastoma multiforme by promoting proliferation by upregulating c-Myc. Su Y, et al. Neuroreport, 2018 Jun 13. PMID 29642232

    See all (116) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Downregulation of TCF7 and LEF1 is a key determinant of tumor-infiltrating regulatory T-cell function.
      Title: Downregulation of TCF7 and LEF1 is a key determinant of tumor-infiltrating regulatory T-cell function.
    2. TCF-1 limits intraepithelial lymphocyte antitumor immunity in colorectal carcinoma.
      Title: TCF-1 limits intraepithelial lymphocyte antitumor immunity in colorectal carcinoma.
    3. Characterization of TCF-1 and its relationship between CD8+ TIL densities and immune checkpoints and their joint influences on prognoses of lung adenocarcinoma patients.
      Title: Characterization of TCF-1 and its relationship between CD8+ TIL densities and immune checkpoints and their joint influences on prognoses of lung adenocarcinoma patients.
    4. Inhibition of ox-LDL-induced endothelial cell injury by LINC02381 knockdown through the microRNA-491-5p/transcription factor 7 axis.
      Title: Inhibition of ox-LDL-induced endothelial cell injury by LINC02381 knockdown through the microRNA-491-5p/transcription factor 7 axis.
    5. Liver X receptor controls follicular helper T cell differentiation via repression of TCF-1.
      Title: Liver X receptor controls follicular helper T cell differentiation via repression of TCF-1.
    6. LncRNA TCF7 contributes to high glucose-induced damage in human podocytes by up-regulating SEMA3A via sponging miR-16-5p.
      Title: LncRNA TCF7 contributes to high glucose-induced damage in human podocytes by up-regulating SEMA3A via sponging miR-16-5p.
    7. Pancreatic stellate cells exploit Wnt/beta-catenin/TCF7-mediated glutamine metabolism to promote pancreatic cancer cells growth.
      Title: Pancreatic stellate cells exploit Wnt/β-catenin/TCF7-mediated glutamine metabolism to promote pancreatic cancer cells growth.
    8. Tcf-1 protects anti-tumor TCR-engineered CD8(+) T-cells from GzmB mediated self-destruction.
      Title: Tcf-1 protects anti-tumor TCR-engineered CD8(+) T-cells from GzmB mediated self-destruction.
    9. Circ3823 contributes to growth, metastasis and angiogenesis of colorectal cancer: involvement of miR-30c-5p/TCF7 axis.
      Title: Circ3823 contributes to growth, metastasis and angiogenesis of colorectal cancer: involvement of miR-30c-5p/TCF7 axis.
    10. TCF7 knockdown inhibits the imatinib resistance of chronic myeloid leukemia K562/G01 cells by neutralizing the Wnt/betacatenin/TCF7/ABC transporter signaling axis.
      Title: TCF7 knockdown inhibits the imatinib resistance of chronic myeloid leukemia K562/G01 cells by neutralizing the Wnt/β‑catenin/TCF7/ABC transporter signaling axis.
    Submit: New GeneRIF Correction See all GeneRIFs (57)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
    EBI GWAS Catalog
    Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ36364, MGC47735

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription repressor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables beta-catenin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transcription cis-regulatory region binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to interleukin-4 IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in gamma-delta T cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in immune response TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of gamma-delta T cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of beta-catenin-TCF complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear body IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    transcription factor 7
    Names
    T-cell-factor-7
    T-cell-specific transcription factor 1
    transcription factor 7 (T-cell specific, HMG-box)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_030367.2 RefSeqGene

      Range
      11465..44994
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001134851.4 → NP_001128323.2  transcription factor 7 isoform 3

      See identical proteins and their annotated locations for NP_001128323.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3, also known as A), differs in the 5' UTR, has multiple coding region differences, uses a downstream start codon, and differs in the 3' UTR, compared to variant 1. The resulting isoform (3) is shorter at the N-terminus and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC011336, HY048657, X59869, X59871
      Consensus CDS
      CCDS47263.2
      UniProtKB/TrEMBL
      E5RG34
      Related
      ENSP00000430179.1, ENST00000518915.5
      Conserved Domains (2) summary
      cd01388
      Location:154 → 224
      SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
      pfam08347
      Location:1 → 97
      CTNNB1_binding; N-terminal CTNNB1 binding

    2. NM_001346425.2 → NP_001333354.1  transcription factor 7 isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) contains an alternate exon in the coding region, compared to variant 1. The resulting isoform (5) is longer, compared to isoform 1.
      Source sequence(s)
      AC008608, AC011336, AK057580, AL832816, BC048769, CR976030, X59870
      UniProtKB/Swiss-Prot
      P36402
      UniProtKB/TrEMBL
      B3KQ75

    3. NM_001346450.2 → NP_001333379.1  transcription factor 7 isoform 7

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) differs in the 5' UTR, has multiple coding region differences, and uses a downstream start codon, compared to variant 1. The resulting isoform (7) is shorter at the N-terminus and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC011336, CN274309, DB128524, X59871
      UniProtKB/TrEMBL
      E5RG34
      Related
      ENSP00000427870.2, ENST00000522375.6

    4. NM_001366502.2 → NP_001353431.1  transcription factor 7 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC011336, AK310591, DB137814
      Conserved Domains (2) summary
      cd01388
      Location:129 → 199
      SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
      pfam08347
      Location:12 → 72
      CTNNB1_binding; N-terminal CTNNB1 binding

    5. NM_003202.5 → NP_003193.2  transcription factor 7 isoform 1

      See identical proteins and their annotated locations for NP_003193.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform (1).
      Source sequence(s)
      AC008608, AC011336, AK057580, AL832816, BC048769, X59870
      Consensus CDS
      CCDS4169.1
      UniProtKB/Swiss-Prot
      P36402
      UniProtKB/TrEMBL
      B3KQ75
      Related
      ENSP00000340347.5, ENST00000342854.10
      Conserved Domains (2) summary
      cd01388
      Location:269 → 339
      SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
      pfam08347
      Location:20 → 212
      CTNNB1_binding; N-terminal CTNNB1 binding

    6. NM_201632.5 → NP_963963.1  transcription factor 7 isoform 2

      See identical proteins and their annotated locations for NP_963963.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2, also known as B), differs in the 5' UTR, has multiple coding region differences, and uses a downstream start codon, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, compared to isoform 1. Both variants 2 and 5 encode the same isoform.
      Source sequence(s)
      AC011336, AK057580, BC048769, DB106996, X59870
      Consensus CDS
      CCDS4170.1
      UniProtKB/TrEMBL
      E5RG34
      Related
      ENSP00000378469.1, ENST00000395023.5
      Conserved Domains (2) summary
      cd01388
      Location:154 → 224
      SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
      pfam08347
      Location:1 → 97
      CTNNB1_binding; N-terminal CTNNB1 binding

    7. NM_201634.5 → NP_963965.1  transcription factor 7 isoform 4

      See identical proteins and their annotated locations for NP_963965.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4, also known as C), differs in the 5' UTR, has multiple coding region differences, uses a downstream start codon, and differs in the 3' UTR, compared to variant 1. The resulting isoform (4) is shorter at the N-terminus and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC011336, CN274309, HY048657, X59871
      Consensus CDS
      CCDS43362.1
      UniProtKB/TrEMBL
      E5RG34
      Related
      ENSP00000367822.4, ENST00000378560.8
      Conserved Domains (2) summary
      cd01388
      Location:154 → 224
      SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
      pfam08347
      Location:1 → 97
      CTNNB1_binding; N-terminal CTNNB1 binding

    8. NM_213648.5 → NP_998813.1  transcription factor 7 isoform 2

      See identical proteins and their annotated locations for NP_998813.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR, has multiple coding region differences, and uses a downstream start codon, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, compared to isoform 1. Both variants 2 and 5 encode the same isoform.
      Source sequence(s)
      AC011336, AK057580, AL832816, BC048769, DB137814, DB161143, X59870
      Consensus CDS
      CCDS4170.1
      UniProtKB/TrEMBL
      E5RG34
      Related
      ENSP00000429547.1, ENST00000520958.5
      Conserved Domains (2) summary
      cd01388
      Location:154 → 224
      SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
      pfam08347
      Location:1 → 97
      CTNNB1_binding; N-terminal CTNNB1 binding

    RNA

    1. NR_033449.3 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) uses an alternate 5' exon structure and lacks an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC008608, AC011336, AK057580

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      134108218..134148210
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047417636.1 → XP_047273592.1  transcription factor 7 isoform X9

    2. XM_047417640.1 → XP_047273596.1  transcription factor 7 isoform X13

    3. XM_047417634.1 → XP_047273590.1  transcription factor 7 isoform X5

    4. XM_047417635.1 → XP_047273591.1  transcription factor 7 isoform X6

    5. XM_047417641.1 → XP_047273597.1  transcription factor 7 isoform X15

    6. XM_047417638.1 → XP_047273594.1  transcription factor 7 isoform X11

    7. XM_006714678.4 → XP_006714741.1  transcription factor 7 isoform X1

      Conserved Domains (2) summary
      cd01388
      Location:300 → 370
      SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
      pfam08347
      Location:20 → 212
      CTNNB1_binding; N-terminal CTNNB1 binding

    8. XM_047417633.1 → XP_047273589.1  transcription factor 7 isoform X4

    9. XM_011543606.2 → XP_011541908.1  transcription factor 7 isoform X7

      Conserved Domains (2) summary
      cd01388
      Location:300 → 370
      SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
      pfam08347
      Location:20 → 212
      CTNNB1_binding; N-terminal CTNNB1 binding

    10. XM_006714682.3 → XP_006714745.1  transcription factor 7 isoform X8

      Conserved Domains (2) summary
      cd01388
      Location:300 → 370
      SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
      pfam08347
      Location:20 → 212
      CTNNB1_binding; N-terminal CTNNB1 binding

    11. XM_006714679.4 → XP_006714742.1  transcription factor 7 isoform X2

      Conserved Domains (2) summary
      cd01388
      Location:269 → 339
      SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
      pfam08347
      Location:20 → 212
      CTNNB1_binding; N-terminal CTNNB1 binding

    12. XM_047417637.1 → XP_047273593.1  transcription factor 7 isoform X10

    13. XM_047417639.1 → XP_047273595.1  transcription factor 7 isoform X12

    14. XM_006714684.3 → XP_006714747.1  transcription factor 7 isoform X14

      UniProtKB/Swiss-Prot
      P36402
      Conserved Domains (2) summary
      cd01388
      Location:269 → 339
      SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
      pfam08347
      Location:20 → 212
      CTNNB1_binding; N-terminal CTNNB1 binding

    15. XM_011543604.3 → XP_011541906.1  transcription factor 7 isoform X3

      Conserved Domains (2) summary
      cd01388
      Location:300 → 370
      SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
      pfam08347
      Location:20 → 212
      CTNNB1_binding; N-terminal CTNNB1 binding

    16. XM_047417643.1 → XP_047273599.1  transcription factor 7 isoform X18

    17. XM_047417642.1 → XP_047273598.1  transcription factor 7 isoform X18

    18. XM_006714685.5 → XP_006714748.1  transcription factor 7 isoform X16

      Conserved Domains (2) summary
      cd01388
      Location:185 → 255
      SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
      pfam08347
      Location:1 → 97
      CTNNB1_binding; N-terminal CTNNB1 binding

    19. XM_006714686.5 → XP_006714749.1  transcription factor 7 isoform X17

      Conserved Domains (2) summary
      cd01388
      Location:154 → 224
      SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
      pfam08347
      Location:1 → 97
      CTNNB1_binding; N-terminal CTNNB1 binding

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      134630059..134671840
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054353323.1 → XP_054209298.1  transcription factor 7 isoform X9

    2. XM_054353327.1 → XP_054209302.1  transcription factor 7 isoform X13

    3. XM_054353319.1 → XP_054209294.1  transcription factor 7 isoform X5

    4. XM_054353320.1 → XP_054209295.1  transcription factor 7 isoform X6

    5. XM_054353329.1 → XP_054209304.1  transcription factor 7 isoform X15

    6. XM_054353325.1 → XP_054209300.1  transcription factor 7 isoform X11

    7. XM_054353315.1 → XP_054209290.1  transcription factor 7 isoform X1

    8. XM_054353318.1 → XP_054209293.1  transcription factor 7 isoform X4

    9. XM_054353321.1 → XP_054209296.1  transcription factor 7 isoform X7

    10. XM_054353322.1 → XP_054209297.1  transcription factor 7 isoform X8

    11. XM_054353316.1 → XP_054209291.1  transcription factor 7 isoform X2

    12. XM_054353324.1 → XP_054209299.1  transcription factor 7 isoform X10

    13. XM_054353326.1 → XP_054209301.1  transcription factor 7 isoform X12

    14. XM_054353328.1 → XP_054209303.1  transcription factor 7 isoform X14

    15. XM_054353317.1 → XP_054209292.1  transcription factor 7 isoform X3

    16. XM_054353335.1 → XP_054209310.1  transcription factor 7 isoform X18

    17. XM_054353334.1 → XP_054209309.1  transcription factor 7 isoform X18

    18. XM_054353336.1 → XP_054209311.1  transcription factor 7 isoform X20

      UniProtKB/TrEMBL
      B3KQ75, B3KSI6

    19. XM_054353330.1 → XP_054209305.1  transcription factor 7 isoform X16

    20. XM_054353331.1 → XP_054209306.1  transcription factor 7 isoform X17

    21. XM_054353332.1 → XP_054209307.1  transcription factor 7 isoform X19

    22. XM_054353333.1 → XP_054209308.1  transcription factor 7 isoform X19

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001134852.1: Suppressed sequence

      Description
      NM_001134852.1: This RefSeq was temporarily suppressed because the CDS may possibly be 5'-partial, and the nature of its 5' end is unclear.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P36402.3 GenPept UniProtKB/Swiss-Prot:P36402

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