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    Flad1 flavin adenine dinucleotide synthetase 1 [ Mus musculus (house mouse) ]

    Gene ID: 319945, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Flad1provided by MGI
    Official Full Name
    flavin adenine dinucleotide synthetase 1provided by MGI
    Primary source
    MGI:MGI:2443030
    See related
    Ensembl:ENSMUSG00000042642 AllianceGenome:MGI:2443030
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pp591; A930017E24Rik
    Summary
    Enables FMN adenylyltransferase activity. Involved in flavin adenine dinucleotide biosynthetic process and riboflavin metabolic process. Is active in cytosol. Orthologous to human FLAD1 (flavin adenine dinucleotide synthetase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in subcutaneous fat pad adult (RPKM 22.3), testis adult (RPKM 20.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Flad1 in Genome Data Viewer
    Location:
    3 F1; 3 39.1 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (89309980..89319188, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (89402673..89411881, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene zinc finger and BTB domain containing 7B Neighboring gene STARR-seq mESC enhancer starr_08237 Neighboring gene STARR-positive B cell enhancer ABC_E3446 Neighboring gene predicted gene 15417 Neighboring gene lens epithelial protein Neighboring gene STARR-positive B cell enhancer ABC_E70 Neighboring gene STARR-seq mESC enhancer starr_08239 Neighboring gene CDC28 protein kinase 1b Neighboring gene src homology 2 domain-containing transforming protein C1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Flavin adenine dinucleotide synthesis in animal tissues. DELUCA C, et al. Biochim Biophys Acta, 1958 Oct. PMID 13584389
    2. Over-expression in Escherichia coli and characterization of two recombinant isoforms of human FAD synthetase. Brizio C, et al. Biochem Biophys Res Commun, 2006 Jun 9. PMID 16643857
    3. FAD Regulates CRYPTOCHROME Protein Stability and Circadian Clock in Mice. Hirano A, et al. Cell Rep, 2017 Apr 11. PMID 28402850, Free PMC Article
    4. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
    5. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Potential readthrough

    Included gene: Lenep

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables FMN adenylyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables FMN adenylyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables FMN adenylyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in FAD biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in FAD biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in flavin adenine dinucleotide biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in riboflavin metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    FAD synthase
    Names
    FAD pyrophosphorylase
    FAD synthetase
    FMN adenylyltransferase
    RFad1, flavin adenine dinucleotide synthetase, homolog
    flavin adenine dinucleotide synthase
    NP_001349304.1
    NP_001349305.1
    NP_796015.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001362375.1 → NP_001349304.1  FAD synthase

      Status: VALIDATED

      Source sequence(s)
      AC171273
      Consensus CDS
      CCDS38492.1
      UniProtKB/Swiss-Prot
      Q3TSN6, Q8BXQ1, Q8R123
      Related
      ENSMUSP00000103049.2, ENSMUST00000107426.8
      Conserved Domains (2) summary
      cd00885
      Location:17 → 171
      cinA; Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of ...
      cd01713
      Location:303 → 453
      PAPS_reductase; This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly ...

    2. NM_001362376.1 → NP_001349305.1  FAD synthase

      Status: VALIDATED

      Source sequence(s)
      AC171273
      Consensus CDS
      CCDS38492.1
      UniProtKB/Swiss-Prot
      Q3TSN6, Q8BXQ1, Q8R123
      Conserved Domains (2) summary
      cd00885
      Location:17 → 171
      cinA; Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of ...
      cd01713
      Location:303 → 453
      PAPS_reductase; This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly ...

    3. NM_177041.4 → NP_796015.2  FAD synthase

      See identical proteins and their annotated locations for NP_796015.2

      Status: VALIDATED

      Source sequence(s)
      BC046769, BY240597
      Consensus CDS
      CCDS38492.1
      UniProtKB/Swiss-Prot
      Q3TSN6, Q8BXQ1, Q8R123
      Related
      ENSMUSP00000122252.3, ENSMUST00000129308.9
      Conserved Domains (2) summary
      cd00885
      Location:17 → 171
      cinA; Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of ...
      cd01713
      Location:303 → 453
      PAPS_reductase; This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly ...

    RNA

    1. NR_155545.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC171273

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      89309980..89319188 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R123.1 GenPept UniProtKB/Swiss-Prot:Q8R123

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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