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    Cfap298 cilia and flagella associate protien 298 [ Mus musculus (house mouse) ]

    Gene ID: 68001, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cfap298provided by MGI
    Official Full Name
    cilia and flagella associate protien 298provided by MGI
    Primary source
    MGI:MGI:1915251
    See related
    Ensembl:ENSMUSG00000022972 AllianceGenome:MGI:1915251
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1110004E09Rik
    Summary
    Predicted to be involved in cilium assembly and regulation of cilium movement. Predicted to be located in cytosol. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; heart; and sensory organ. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 26. Orthologous to human CFAP298 (cilia and flagella associated protein 298). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 38.1), CNS E11.5 (RPKM 13.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cfap298 in Genome Data Viewer
    Location:
    16 C3.3; 16 52.17 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (90721178..90731737, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (90925811..90934849, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_41464 Neighboring gene URB1 ribosome biogenesis 1 homolog (S. cerevisiae) Neighboring gene STARR-positive B cell enhancer ABC_E1929 Neighboring gene eva-1 homolog C Neighboring gene predicted gene, 36363 Neighboring gene STARR-seq mESC enhancer starr_41466 Neighboring gene STARR-seq mESC enhancer starr_41467 Neighboring gene STARR-seq mESC enhancer starr_41468 Neighboring gene predicted gene, 53919 Neighboring gene STARR-positive B cell enhancer ABC_E4188 Neighboring gene synaptojanin 1 Neighboring gene RIKEN cDNA 4930404I05 gene Neighboring gene STARR-positive B cell enhancer mm9_chr16:91012148-91012449 Neighboring gene STARR-seq mESC enhancer starr_41471 Neighboring gene PAX3 and PAX7 binding protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A gene expression map of human chromosome 21 orthologues in the mouse. Gitton Y, et al. Nature, 2002 Dec 5. PMID 12466855
    2. Human chromosome 21 gene expression atlas in the mouse. Reymond A, et al. Nature, 2002 Dec 5. PMID 12466854
    3. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
    4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in cilium assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cilium movement IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cilium movement ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cilium IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    cilia- and flagella-associated protein 298
    Names
    UPF0769 protein C21orf59 homolog
    protein kurly homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026502.2 → NP_080778.2  cilia- and flagella-associated protein 298

      See identical proteins and their annotated locations for NP_080778.2

      Status: VALIDATED

      Source sequence(s)
      AK045905, CX236612
      Consensus CDS
      CCDS28321.1
      UniProtKB/Swiss-Prot
      Q8BL95, Q8VCL7
      UniProtKB/TrEMBL
      Q9CU27
      Related
      ENSMUSP00000023694.4, ENSMUST00000023694.11
      Conserved Domains (1) summary
      pfam11069
      Location:189 → 285
      DUF2870; Protein of unknown function (DUF2870)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      90721178..90731737 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036160103.1 → XP_036015996.1  cilia- and flagella-associated protein 298 isoform X1

      UniProtKB/TrEMBL
      Q9CU27
      Conserved Domains (1) summary
      pfam11069
      Location:145 → 239
      DUF2870; Protein of unknown function (DUF2870)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BL95.1 GenPept UniProtKB/Swiss-Prot:Q8BL95

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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