fliC flagellar filament structural protein [Escherichia coli str. K-12 substr. MG1655] - Gene

Summary

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Official Symbol: fliC
Official Full Name: flagellar filament structural protein
Primary source: ECOCYC:EG10321
Locus tag: b1923
See related: ASAP:ABE-0006402
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage: Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as: ECK1922; flaF; H; hag
Summary: Flagellar regulon. [More information is available at EcoGene: EG10321]. FliC, or flagellin, is the basic subunit that polymerizes to form the rigid flagellar filament of Escherichia coli. [More information is available at EcoCyc: EG10321].
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Genomic context

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Sequence:: NC_000913.3 (2002110..2003606, complement)

NC_000913.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Molecular Determinants of Filament Capping Proteins Required for the Formation of Functional Flagella in Gram-Negative Bacteria.
Title: Molecular Determinants of Filament Capping Proteins Required for the Formation of Functional Flagella in Gram-Negative Bacteria.
The authors conclude that detection of Escherichia coli FliC through TLR5 triggers rapid IL-10 synthesis in the bladder.
Title: Rapid Bladder Interleukin-10 Synthesis in Response to Uropathogenic Escherichia coli Is Part of a Defense Strategy Triggered by the Major Bacterial Flagellar Filament FliC and Contingent on TLR5.
Studies indicate that toll-like receptor 5 (TLR5) specifically interacts with flagellin, and is useful as an analytical recognition element for low concentrations of flagellin.
Title: The effects of lipids and surfactants on TLR5-proteoliposome functionality for flagellin detection using surface plasmon resonance biosensing.
Flagellin subunit FliC function as adhesins to piglet epithelial cells invasion.
Title: Contribution of flagellin subunit FliC to piglet epithelial cells invasion by F18ab E. coli.
New promising vaccine combinations based on the FliC antigen against urinary tract infections caused by uropathogenic Escherichia coli.
Title: Assessment of immune responses of the flagellin (FliC) fused to FimH adhesin of Uropathogenic Escherichia coli.
Results showed a reproducible and clear cut classification with molecular polymorphism of gene rfb cluster and flagella gene fliC.
Title: Molecular typing of Escherichia coli strains isolated from food in Casablanca (Morocco).
Increased IL-8 levels mainly depended on flagellin expression as fliC-negative EPEC did not elicit a significant IL-8 response despite increased mucosal colonization compared with wild-type EPEC.
Title: The ex vivo response of human intestinal mucosa to enteropathogenic Escherichia coli infection.
FliC is secreted by the LEE-encoded type III secretion system and stimulates TLR5 signalling but does not confer motility.
Title: Secretion of flagellin by the LEE-encoded type III secretion system of enteropathogenic Escherichia coli.
Binding of a fliC(H7) mutant O157 strain to rectal epithelium was significantly reduced as was binding of the flagellated wild-type strain following incubation with H7-specific antibodies.
Title: An investigation of the expression and adhesin function of H7 flagella in the interaction of Escherichia coli O157 : H7 with bovine intestinal epithelium.
Insertion of Cys-derived thiol residues in the E. coli FliC protein increased Au(III) sorption and reduction onto the surface of the flagellar filament and resulted in the production of stabilized Au(0) nanoparticles of approximately 20-50 nm diameter.
Title: Manufacture of stable palladium and gold nanoparticles on native and genetically engineered flagella scaffolds.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by EcoCyc

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables structural molecule activity	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in bacterial-type flagellum	IEA Inferred from Electronic Annotation more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: flagellar filament structural protein

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_000913.3 Reference assembly

Range

2002110..2003606 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NP_416433.1 flagellar filament structural protein [Escherichia coli str. K-12 substr. MG1655]

See identical proteins and their annotated locations for NP_416433.1

Status: PROVISIONAL

UniProtKB/TrEMBL

Q2A873

Conserved Domains (1) summary

PRK08026
Location:1 → 498

PRK08026; FliC/FljB family flagellin