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    epmA EF-P-lysine lysyltransferase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948672, updated on 3-Dec-2024

    Summary

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    Official Symbol
    epmA
    Official Full Name
    EF-P-lysine lysyltransferase
    Primary source
    ECOCYC:EG11211
    Locus tag
    b4155
    See related
    ASAP:ABE-0013610
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK4151; genX; poxA; yjeA
    Summary
    The poxA pleiotropic phenotypes are not due to a defect in pyruvate oxidase. [More information is available at EcoGene: EG11211]. PoxA is suggested to regulate pyruvate oxidase . [More information is available at EcoCyc: EG11211].
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    Genomic context

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    Sequence:
    NC_000913.3 (4382643..4383620)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene fumarate reductase membrane protein FrdC Neighboring gene fumarate reductase iron-sulfur protein Neighboring gene fumarate reductase flavoprotein subunit Neighboring gene putative transporter YjeM Neighboring gene uncharacterized protein YjeN Neighboring gene DUF2645 domain-containing inner membrane protein YjeO

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. De-novo designed β-lysine derivatives can both augment and diminish the proliferation rates of E. coli through the action of Elongation Factor P. McDonnell CM, et al. Bioorg Med Chem Lett, 2022 Mar 1. PMID 35032607
    2. Evidence for a new Escherichia coli protein resembling a lysyl-tRNA synthetase. Kong L, et al. Gene, 1991 Dec 1. PMID 1761227
    3. Pleiotropic effects of poxA regulatory mutations of Escherichia coli and Salmonella typhimurium, mutations conferring sulfometuron methyl and alpha-ketobutyrate hypersensitivity. Van Dyk TK, et al. J Bacteriol, 1987 Oct. PMID 2820932, Free PMC Article
    4. Mapping nonselectable genes of Escherichia coli by using transposon Tn10: location of a gene affecting pyruvate oxidase. Chang YY, et al. J Bacteriol, 1982 Sep. PMID 6286595, Free PMC Article
    5. Molecular and functional characterization of Salmonella enterica serovar typhimurium poxA gene: effect on attenuation of virulence and protection. Kaniga K, et al. Infect Immun, 1998 Dec. PMID 9826331, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. De-novo designed beta-lysine derivatives can both augment and diminish the proliferation rates of E. coli through the action of Elongation Factor P.
      Title: De-novo designed β-lysine derivatives can both augment and diminish the proliferation rates of E. coli through the action of Elongation Factor P.
    2. Synthetic post-translational modifications of elongation factor P using the ligase EpmA.
      Title: Synthetic post-translational modifications of elongation factor P using the ligase EpmA.
    3. GenX-elongation factor P-lysyl adenylate analogue crystals belonged to the monoclinic space group P2(1), with unit-cell parameters a=105.93, b=102.96, c=119.94 A, beta=99.4 degrees, and diffracted to 2.5 A resolution
      Title: Crystallization and preliminary X-ray crystallographic study of GenX, a lysyl-tRNA synthetase paralogue from Escherichia coli, in complex with translation elongation factor P.
    4. reveal that the translation elongation factor P (EF-P) lysylation by GenX is enhanced by YjeK (lysine 2,3-aminomutase paralog)
      Title: A paralog of lysyl-tRNA synthetase aminoacylates a conserved lysine residue in translation elongation factor P.
    5. Misacylation of yeast amber suppressor tRNA(Tyr) is via E. coli lysyl-tRNA synthetase.
      Title: Misacylation of yeast amber suppressor tRNA(Tyr) by E. coli lysyl-tRNA synthetase and its effective repression by genetic engineering of the tRNA sequence.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acid-ammonia (or amide) ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lysine-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lysine-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein-lysine lysyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables tRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to acidic pH IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lysyl-tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lysyl-tRNA aminoacylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within post-translational protein modification RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    EF-P-lysine lysyltransferase

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      4382643..4383620
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418579.2 EF-P-lysine lysyltransferase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418579.2

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A0H2Z5K9, A0A1X3J951, C3SGA2
      Conserved Domains (1) summary
      PRK09350
      Location:12 → 317
      PRK09350; elongation factor P--(R)-beta-lysine ligase
    Nucleotide Protein
    Heading Accession and Version

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