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    ST13 ST13 Hsp70 interacting protein [ Homo sapiens (human) ]

    Gene ID: 6767, updated on 10-Dec-2024

    Summary

    Official Symbol
    ST13provided by HGNC
    Official Full Name
    ST13 Hsp70 interacting proteinprovided by HGNC
    Primary source
    HGNC:HGNC:11343
    See related
    Ensembl:ENSG00000100380 MIM:606796; AllianceGenome:HGNC:11343
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HIP; HOP; P48; AAG2; SNC6; HSPABP; FAM10A1; FAM10A4; HSPABP1; PRO0786
    Summary
    The protein encoded by this gene is an adaptor protein that mediates the association of the heat shock proteins HSP70 and HSP90. This protein has been shown to be involved in the assembly process of glucocorticoid receptor, which requires the assistance of multiple molecular chaperones. The expression of this gene is reported to be downregulated in colorectal carcinoma tissue suggesting that it is a candidate tumor suppressor gene. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2013]
    Expression
    Ubiquitous expression in ovary (RPKM 177.9), kidney (RPKM 97.3) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See ST13 in Genome Data Viewer
    Location:
    22q13.2
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (40824535..40856639, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (41296730..41328831, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (41220539..41252643, complement)

    Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene solute carrier family 25 member 17 Neighboring gene jumping translocation breakpoint pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19100 Neighboring gene microRNA 4766 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:41252371-41253140 Neighboring gene X-prolyl aminopeptidase 3 Neighboring gene DnaJ heat shock protein family (Hsp40) member B7 Neighboring gene uncharacterized LOC124905124

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ27260, MGC129952

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables Hsp70 protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein-macromolecule adaptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in chaperone cofactor-dependent protein refolding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein folding TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in response to bacterium IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in extracellular exosome HDA PubMed 

    General protein information

    Preferred Names
    hsc70-interacting protein
    Names
    Hsp70-interacting protein
    aging-associated protein 2
    heat shock 70kD protein binding protein
    progesterone receptor-associated p48 protein
    putative tumor suppressor ST13
    renal carcinoma antigen NY-REN-33
    suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)
    suppression of tumorigenicity 13 protein
    testis secretory sperm-binding protein Li 233m

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001278589.2NP_001265518.1  hsc70-interacting protein isoform 2

      See identical proteins and their annotated locations for NP_001265518.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AK303530, BM679025, Z98048
      UniProtKB/Swiss-Prot
      Q8NFI4
      UniProtKB/TrEMBL
      B4E0U6
      Conserved Domains (5) summary
      smart00727
      Location:309348
      STI1; Heat shock chaperonin-binding motif
      cd14438
      Location:343
      Hip_N; N-terminal dimerization domain of the Hsp70-interacting protein (Hip) and similar proteins
      sd00006
      Location:137167
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:138170
      TPR_1; Tetratricopeptide repeat
      pfam13414
      Location:103169
      TPR_11; TPR repeat
    2. NM_003932.5NP_003923.2  hsc70-interacting protein isoform 1

      See identical proteins and their annotated locations for NP_003923.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      BC121107, BM679025, U17714, Z98048
      Consensus CDS
      CCDS14006.1
      UniProtKB/Swiss-Prot
      O14999, P50502, Q2TU77, Q8NFI4
      UniProtKB/TrEMBL
      A0A140VKA6
      Related
      ENSP00000216218.3, ENST00000216218.8
      Conserved Domains (4) summary
      PLN03088
      Location:114233
      PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
      cd14438
      Location:343
      Hip_N; N-terminal dimerization domain of the Hsp70-interacting protein (Hip) and similar proteins
      sd00006
      Location:147177
      TPR; TPR repeat [structural motif]
      pfam17830
      Location:316361
      STI1; STI1 domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

      Range
      40824535..40856639 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060946.1 Alternate T2T-CHM13v2.0

      Range
      41296730..41328831 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)