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    fliD flagellar filament capping protein [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946428, updated on 3-Dec-2024

    Summary

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    Official Symbol
    fliD
    Official Full Name
    flagellar filament capping protein
    Primary source
    ECOCYC:EG10841
    Locus tag
    b1924
    See related
    ASAP:ABE-0006407
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1923; flbC; rfs
    Summary
    Flagellar regulon. [More information is available at EcoGene: EG10841]. The filament cap lies at the distal, growing end of the flagellar filament and plays a critical role in the assembly of flagellin (FliC) monomers into the growing filament . [More information is available at EcoCyc: EG10841].
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    Genomic context

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    Sequence:
    NC_000913.3 (2003872..2005278)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene flagellar filament structural protein Neighboring gene flagellar biosynthesis protein FliS Neighboring gene flagellar biosynthesis protein FliT

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Excretion of unassembled flagellin by Salmonella typhimurium mutants deficient in hook-associated proteins. Homma M, et al. J Bacteriol, 1984 Sep. PMID 6384179, Free PMC Article
    2. Self-Oligomerizing Structure of the Flagellar Cap Protein FliD and Its Implication in Filament Assembly. Song WS, et al. J Mol Biol, 2017 Mar 24. PMID 28179186
    3. Isolation and characterization of Escherichia coli hag operator mutants whose hag48 expression has become repressible by a Salmonella H1 repressor. Hanafusa T, et al. Mol Gen Genet, 1989 Mar. PMID 2659972
    4. DNA sequence adjacent to flagellar genes and evolution of flagellar-phase variation. Szekely E, et al. J Bacteriol, 1983 Jul. PMID 6305924, Free PMC Article
    5. Molecular Determinants of Filament Capping Proteins Required for the Formation of Functional Flagella in Gram-Negative Bacteria. Nedeljković M, et al. Biomolecules, 2021 Sep 22. PMID 34680030, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Molecular Determinants of Filament Capping Proteins Required for the Formation of Functional Flagella in Gram-Negative Bacteria.
      Title: Molecular Determinants of Filament Capping Proteins Required for the Formation of Functional Flagella in Gram-Negative Bacteria.
    2. Escherichia coli FliD consists of three domains (D1, D2, and D3) and forms a hexamer plate of the D2 and D3 domains that resembles a six-pointed star with legs consisting of the D1 domain. In contrast, the D2 and D3 domains of Salmonella typhimurium FliD assemble into a pentamer as a five-pointed star plate. Despite their distinct oligomeric states, ecFliD and stFliD engage a common molecular surface for oligomerization.
      Title: Self-Oligomerizing Structure of the Flagellar Cap Protein FliD and Its Implication in Filament Assembly.
    3. analysis of integration and expression at four candidate loci, fliD, fliS, fliT, and fliY, of the E. coli flagellar region 3a
      Title: Escherichia coli flagellar genes as target sites for integration and expression of genetic circuits.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in bacterial-type flagellum-dependent cell motility IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within bacterial-type flagellum-dependent cell motility IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in bacterial-type flagellum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in bacterial-type flagellum filament cap IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in bacterial-type flagellum filament cap IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in bacterial-type flagellum hook IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    flagellar filament capping protein

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2003872..2005278
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416434.1 flagellar filament capping protein [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416434.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A377DSH9, A0A5N8HAI3, A0A6D0ICE8
      Conserved Domains (1) summary
      PRK08032
      Location:1 → 462
      fliD; flagellar capping protein; Reviewed
    Nucleotide Protein
    Heading Accession and Version

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