U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    rutA pyrimidine monooxygenase RutA [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945643, updated on 17-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    rutA
    Official Full Name
    pyrimidine monooxygenase RutA
    Primary source
    ECOCYC:G6523
    Locus tag
    b1012
    See related
    ASAP:ABE-0003416
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1003; ycdM
    Summary
    NtrC regulon. [More information is available at EcoGene: EG13859]. Escherichia coli K-12 contains a previously undescribed pathway for pyrimidine degradation. [More information is available at EcoCyc: G6523].
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Sequence:
    NC_000913.3 (1072863..1074011, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative aminoacrylate hydrolase RutD Neighboring gene 3-aminoacrylate deaminase Neighboring gene ureidoacrylate amidohydrolase Neighboring gene DNA-binding transcriptional dual regulator RutR Neighboring gene fused DNA-binding transcriptional repressor/proline dehydrogenase/1-pyrroline-5-carboxylate dehydrogenase PutA

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Aminoperoxide adducts expand the catalytic repertoire of flavin monooxygenases. Matthews A, et al. Nat Chem Biol, 2020 May. PMID 32066967
    2. Catalysis of a flavoenzyme-mediated amide hydrolysis. Mukherjee T, et al. J Am Chem Soc, 2010 Apr 28. PMID 20369853, Free PMC Article
    3. Comparative genomics reveals novel biochemical pathways. Piskur J, et al. Trends Genet, 2007 Aug. PMID 17555842
    4. A hidden metabolic pathway exposed. Osterman A. Proc Natl Acad Sci U S A, 2006 Apr 11. PMID 16595627, Free PMC Article
    5. RutR is the uracil/thymine-sensing master regulator of a set of genes for synthesis and degradation of pyrimidines. Shimada T, et al. Mol Microbiol, 2007 Nov. PMID 17919280

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RutA structure has a structural motif for dioxygen activation and N5-functionalization.
      Title: Aminoperoxide adducts expand the catalytic repertoire of flavin monooxygenases.
    Submit: New GeneRIF Correction

    Pathways from PubChem

    Go to the top of the page

    General gene information

    Go to the top of the page Help

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables alkanesulfonate monooxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables monooxygenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables uracil oxygenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables uracil oxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in alkanesulfonate catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nitrogen utilization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in nitrogen utilization IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within nitrogen utilization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within pyrimidine nucleobase catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in thymine catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in uracil catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in uracil catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within uracil catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    pyrimidine monooxygenase RutA
    NP_415532.3

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1072863..1074011 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415532.3 pyrimidine monooxygenase RutA [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415532.3

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      B7LFC2, B7N3G8
      UniProtKB/TrEMBL
      A0A148HS85, A0A8T9D3G5, A0AA35AHJ0
      Conserved Domains (1) summary
      TIGR03612
      Location:20 → 374
      RutA; pyrimidine utilization protein A
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.