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    Gata6 GATA binding protein 6 [ Mus musculus (house mouse) ]

    Gene ID: 14465, updated on 14-Jan-2025

    Summary

    Official Symbol
    Gata6provided by MGI
    Official Full Name
    GATA binding protein 6provided by MGI
    Primary source
    MGI:MGI:107516
    See related
    Ensembl:ENSMUSG00000005836 AllianceGenome:MGI:107516
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    GATA-6
    Summary
    Enables several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and transcription coactivator binding activity. Involved in gene expression; heart contraction; and sinoatrial node development. Acts upstream of or within several processes, including cardiac muscle hypertrophy in response to stress; endodermal cell fate determination; and epithelial cell differentiation. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including central nervous system; early conceptus; embryo mesenchyme; gut; and heart. Human ortholog(s) of this gene implicated in adenocarcinoma (multiple); congenital heart disease (multiple); and pancreatic hypoplasia-diabetes-congenital heart disease syndrome. Orthologous to human GATA6 (GATA binding protein 6). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in adrenal adult (RPKM 88.8), ovary adult (RPKM 57.8) and 10 other tissues See more
    Orthologs
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    Genomic context

    See Gata6 in Genome Data Viewer
    Location:
    18 A1; 18 5.63 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (11052510..11085636)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (11052510..11085636)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 35814 Neighboring gene STARR-seq mESC enhancer starr_43807 Neighboring gene STARR-seq mESC enhancer starr_43808 Neighboring gene RIKEN cDNA 9130001E16 gene Neighboring gene STARR-seq mESC enhancer starr_43809 Neighboring gene PHD finger protein 14 pseudogene Neighboring gene GATA binding protein 6, opposite strand Neighboring gene VISTA enhancer mm138 Neighboring gene predicted gene, 35918 Neighboring gene STARR-positive B cell enhancer ABC_E8703 Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:11816567-11816720 Neighboring gene STARR-seq mESC enhancer starr_43816 Neighboring gene retinoblastoma binding protein 8, endonuclease Neighboring gene predicted gene, 54029

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (8) 
    • Targeted (13)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by MGI

    Items 1 - 25 of 26
    Function Evidence Code Pubs
    enables DNA binding PubMed 
    enables DNA-binding transcription factor activity PubMed 
    enables DNA-binding transcription factor activity  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific  
    enables DNA-binding transcription factor binding  
    enables NFAT protein binding  
    enables NFAT protein binding  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding PubMed 
    enables RNA polymerase II-specific DNA-binding transcription factor binding PubMed 
    enables chromatin binding PubMed 
    enables cis-regulatory region sequence-specific DNA binding  
    enables double-stranded DNA binding  
    enables protein binding PubMed 
    enables protein kinase binding  
    enables protein kinase binding  
    enables sequence-specific DNA binding PubMed 
    enables sequence-specific DNA binding  
    enables sequence-specific double-stranded DNA binding  
    enables transcription cis-regulatory region binding PubMed 
    enables transcription coactivator binding PubMed 
    enables transcription coactivator binding  
    enables transcription factor binding PubMed 
    enables zinc ion binding  
    Items 1 - 25 of 26
    Items 1 - 25 of 86
    Process Evidence Code Pubs
    involved_in G1 to G0 transition involved in cell differentiation  
    acts_upstream_of_or_within_negative_effect G1 to G0 transition involved in cell differentiation  
    acts_upstream_of_or_within animal organ formation PubMed 
    acts_upstream_of_or_within cardiac muscle cell differentiation PubMed 
    acts_upstream_of_or_within cardiac muscle cell differentiation PubMed 
    acts_upstream_of cardiac muscle cell proliferation PubMed 
    acts_upstream_of_or_within cardiac muscle hypertrophy in response to stress PubMed 
    acts_upstream_of_or_within cardiac muscle tissue development PubMed 
    involved_in cardiac vascular smooth muscle cell differentiation  
    involved_in cardiac vascular smooth muscle cell differentiation  
    involved_in cell fate commitment  
    acts_upstream_of_or_within cellular response to BMP stimulus PubMed 
    acts_upstream_of_or_within cellular response to gonadotropin stimulus PubMed 
    involved_in cellular response to hypoxia  
    involved_in cellular response to hypoxia  
    acts_upstream_of_or_within club cell differentiation PubMed 
    acts_upstream_of_or_within endodermal cell differentiation PubMed 
    acts_upstream_of_or_within endodermal cell fate determination PubMed 
    involved_in epithelial cell differentiation  
    acts_upstream_of_or_within epithelial cell differentiation PubMed 
    involved_in gene expression PubMed 
    involved_in heart contraction PubMed 
    acts_upstream_of_or_within in utero embryonic development PubMed 
    acts_upstream_of_or_within intestinal epithelial cell differentiation PubMed 
    acts_upstream_of_or_within liver development PubMed 
    acts_upstream_of_or_within lung saccule development PubMed 
    involved_in male gonad development  
    involved_in negative regulation of DNA-templated transcription  
    involved_in negative regulation of apoptotic process  
    involved_in negative regulation of apoptotic process  
    involved_in negative regulation of miRNA transcription  
    involved_in negative regulation of miRNA transcription  
    involved_in negative regulation of sebum secreting cell proliferation  
    involved_in negative regulation of sebum secreting cell proliferation  
    involved_in negative regulation of transcription by RNA polymerase II  
    involved_in negative regulation of transcription by RNA polymerase II  
    involved_in negative regulation of transcription by RNA polymerase II  
    involved_in negative regulation of transforming growth factor beta1 production  
    involved_in negative regulation of transforming growth factor beta1 production  
    involved_in negative regulation of transforming growth factor beta2 production  
    involved_in negative regulation of transforming growth factor beta2 production  
    involved_in odontogenesis of dentin-containing tooth  
    involved_in outflow tract septum morphogenesis  
    involved_in outflow tract septum morphogenesis  
    acts_upstream_of_or_within pancreas development PubMed 
    acts_upstream_of_or_within pancreatic A cell differentiation PubMed 
    acts_upstream_of_or_within phospholipid metabolic process PubMed 
    involved_in positive regulation of BMP signaling pathway  
    involved_in positive regulation of BMP signaling pathway  
    acts_upstream_of_or_within positive regulation of DNA-templated transcription PubMed 
    involved_in positive regulation of DNA-templated transcription  
    involved_in positive regulation of angiogenesis  
    involved_in positive regulation of angiogenesis  
    involved_in positive regulation of apoptotic process  
    involved_in positive regulation of cardiac muscle cell apoptotic process  
    involved_in positive regulation of cardiac muscle cell apoptotic process  
    acts_upstream_of_or_within positive regulation of cardiac muscle cell proliferation PubMed 
    involved_in positive regulation of cardiac muscle myoblast proliferation  
    involved_in positive regulation of cardiac muscle myoblast proliferation  
    involved_in positive regulation of transcription by RNA polymerase II  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II PubMed 
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in regulation of antimicrobial humoral response  
    involved_in regulation of antimicrobial humoral response  
    acts_upstream_of_or_within regulation of gene expression PubMed 
    involved_in response to cAMP  
    acts_upstream_of_or_within response to estrogen PubMed 
    involved_in response to growth factor  
    involved_in response to retinoic acid  
    involved_in response to retinoic acid  
    involved_in response to toxic substance  
    involved_in response to xenobiotic stimulus  
    involved_in response to xenobiotic stimulus  
    involved_in sebaceous gland cell differentiation  
    involved_in sebaceous gland cell differentiation  
    involved_in sinoatrial node development PubMed 
    involved_in skin epidermis development  
    involved_in skin epidermis development  
    involved_in smooth muscle cell differentiation  
    acts_upstream_of_or_within stem cell differentiation PubMed 
    acts_upstream_of_or_within stem cell differentiation PubMed 
    acts_upstream_of_or_within tube morphogenesis PubMed 
    acts_upstream_of_or_within type B pancreatic cell differentiation PubMed 
    acts_upstream_of_or_within type II pneumocyte differentiation PubMed 
    Items 1 - 25 of 86
    Component Evidence Code Pubs
    located_in nuclear membrane  
    located_in nuclear membrane  
    located_in nucleoplasm  
    located_in nucleoplasm  
    is_active_in nucleus  
    located_in nucleus PubMed 
    located_in nucleus PubMed 
    part_of transcription regulator complex PubMed 

    General protein information

    Preferred Names
    transcription factor GATA-6
    Names
    GATA-binding factor 6

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010258.3NP_034388.2  transcription factor GATA-6

      See identical proteins and their annotated locations for NP_034388.2

      Status: VALIDATED

      Source sequence(s)
      AI120546, AK142381, BB042635, BY084328
      Consensus CDS
      CCDS29059.1
      UniProtKB/Swiss-Prot
      P97729, Q3UQJ2, Q61169, Q9QZK3
      Related
      ENSMUSP00000041774.8, ENSMUST00000047762.10
      Conserved Domains (3) summary
      smart00401
      Location:435482
      ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
      cd00202
      Location:437488
      ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
      pfam05349
      Location:147371
      GATA-N; GATA-type transcription activator, N-terminal

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      11052510..11085636
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017317834.1XP_017173323.1  transcription factor GATA-6 isoform X1

      Conserved Domains (2) summary
      cd00202
      Location:437488
      ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
      pfam05349
      Location:147371
      GATA-N; GATA-type transcription activator, N-terminal
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