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    Fnbp1 formin binding protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 14269, updated on 9-Dec-2024

    Summary

    Official Symbol
    Fnbp1provided by MGI
    Official Full Name
    formin binding protein 1provided by MGI
    Primary source
    MGI:MGI:109606
    See related
    Ensembl:ENSMUSG00000075415 AllianceGenome:MGI:109606
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    FBP1; Fbp17; 1110057E06Rik; 2210010H06Rik
    Summary
    Predicted to enable identical protein binding activity. Predicted to be involved in nervous system development. Predicted to be located in intracellular membrane-bounded organelle and plasma membrane. Is expressed in bladder; central nervous system; dorsal root ganglion; and gut. Orthologous to human FNBP1 (formin binding protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 39.4), bladder adult (RPKM 33.9) and 26 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Fnbp1 in Genome Data Viewer
    Location:
    2 B; 2 21.78 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (30916218..31032046, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (31026206..31145454, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene cDNA sequence BC005624 Neighboring gene predicted gene, 39786 Neighboring gene ubiquitin specific peptidase 20 Neighboring gene STARR-positive B cell enhancer ABC_E9195 Neighboring gene STARR-positive B cell enhancer ABC_E4431 Neighboring gene STARR-seq mESC enhancer starr_04135 Neighboring gene STARR-positive B cell enhancer ABC_E4432 Neighboring gene STARR-positive B cell enhancer ABC_E9196 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:30971715-30971947 Neighboring gene STARR-positive B cell enhancer ABC_E5904 Neighboring gene RIKEN cDNA D330023K18 gene Neighboring gene STARR-seq mESC enhancer starr_04141 Neighboring gene STARR-positive B cell enhancer ABC_E10092 Neighboring gene G protein-coupled receptor 107 Neighboring gene predicted gene, 22516

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in endocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in nervous system development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cell cortex IEA
    Inferred from Electronic Annotation
    more info
     
    located_in clathrin-coated pit IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    formin-binding protein 1
    Names
    formin binding protein 17

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001038700.2NP_001033789.1  formin-binding protein 1 isoform a

      See identical proteins and their annotated locations for NP_001033789.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) lacks two alternate, in-frame exons, compared to variant 3. The resulting protein (isoform a) is shorter when it is compared to isoform c.
      Source sequence(s)
      AI843002, AK122308, AK143512
      Consensus CDS
      CCDS38097.1
      UniProtKB/TrEMBL
      A2AQ42
      Related
      ENSMUSP00000109192.3, ENSMUST00000113562.9
      Conserved Domains (3) summary
      cd07676
      Location:5257
      F-BAR_FBP17; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Formin Binding Protein 17
      cl00087
      Location:340416
      HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases
      cl17036
      Location:486542
      SH3; Src Homology 3 domain superfamily
    2. NM_001177648.1NP_001171119.1  formin-binding protein 1 isoform c

      See identical proteins and their annotated locations for NP_001171119.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents the longest transcript and it encodes the longest protein (isoform c).
      Source sequence(s)
      AI843002, AK122308
      Consensus CDS
      CCDS50561.1
      UniProtKB/Swiss-Prot
      A2AQ40, A2AQ46, Q3TA45, Q3TCW9, Q3U081, Q3UPI7, Q80TY0, Q8C727, Q99L37
      UniProtKB/TrEMBL
      A2AQ42
      Related
      ENSMUSP00000109190.2, ENSMUST00000113560.8
      Conserved Domains (3) summary
      cd07676
      Location:5257
      F-BAR_FBP17; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Formin Binding Protein 17
      cd12071
      Location:552608
      SH3_FBP17; Src Homology 3 domain of Formin Binding Protein 17
      cl00087
      Location:406482
      HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases
    3. NM_001177649.1NP_001171120.1  formin-binding protein 1 isoform d

      See identical proteins and their annotated locations for NP_001171120.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks two alternate, in-frame exons and uses a different splice site in the 3' coding region, compared to variant 3. The resulting protein (isoform d) is shorter when it is compared to isoform c.
      Source sequence(s)
      AI843002, AK122308, AL844546
      Consensus CDS
      CCDS57165.1
      UniProtKB/TrEMBL
      A2AQ42
      Related
      ENSMUSP00000109194.3, ENSMUST00000113564.9
      Conserved Domains (3) summary
      cd07676
      Location:5257
      F-BAR_FBP17; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Formin Binding Protein 17
      cl00087
      Location:340416
      HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases
      cl17036
      Location:487543
      SH3; Src Homology 3 domain superfamily
    4. NM_001177650.1NP_001171121.1  formin-binding protein 1 isoform e

      See identical proteins and their annotated locations for NP_001171121.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) has multiple differences, compared to variant 3. These differences result in a distinct 5' UTR and cause translation initiation at a downstream start codon, compared to variant 1. The encoded protein (isoform e) is shorter when it is compared to isoform c.
      Source sequence(s)
      AI843002, AK122308, AK143512
      Consensus CDS
      CCDS50560.1
      UniProtKB/TrEMBL
      A2AQ42
      Related
      ENSMUSP00000109189.4, ENSMUST00000113559.10
      Conserved Domains (3) summary
      cl00087
      Location:312388
      HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases
      cl12013
      Location:1178
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
      cl17036
      Location:458514
      SH3; Src Homology 3 domain superfamily
    5. NM_001355105.1NP_001342034.1  formin-binding protein 1 isoform f

      Status: VALIDATED

      Source sequence(s)
      AL844546
      UniProtKB/TrEMBL
      A2AQ42
      Conserved Domains (3) summary
      cd07676
      Location:5257
      F-BAR_FBP17; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Formin Binding Protein 17
      cl00087
      Location:345421
      HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases
      cl17036
      Location:492548
      SH3; Src Homology 3 domain superfamily
    6. NM_001355106.1NP_001342035.1  formin-binding protein 1 isoform g

      Status: VALIDATED

      Source sequence(s)
      AL844546
      UniProtKB/TrEMBL
      A2AQ42
      Conserved Domains (3) summary
      cd07676
      Location:5257
      F-BAR_FBP17; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Formin Binding Protein 17
      cl00087
      Location:345421
      HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases
      cl17036
      Location:491547
      SH3; Src Homology 3 domain superfamily
    7. NM_019406.3NP_062279.1  formin-binding protein 1 isoform b

      See identical proteins and their annotated locations for NP_062279.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses a different segment for its 3' coding region and UTR, compared to variant 3. The resulting protein (isoform b) has a different and shorter C-terminus when it is compared to isoform c.
      Source sequence(s)
      AK122308, AL844546, BX635769
      Consensus CDS
      CCDS15894.1
      UniProtKB/Swiss-Prot
      Q80TY0
      Related
      ENSMUSP00000109181.3, ENSMUST00000113552.9
      Conserved Domains (1) summary
      cd07676
      Location:5257
      F-BAR_FBP17; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Formin Binding Protein 17

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      30916218..31032046 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030247490.2XP_030103350.1  formin-binding protein 1 isoform X9

      UniProtKB/TrEMBL
      A2AQ42
      Conserved Domains (3) summary
      cd07676
      Location:5257
      F-BAR_FBP17; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Formin Binding Protein 17
      cl00087
      Location:401477
      HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases
      cl17036
      Location:547603
      SH3; Src Homology 3 domain superfamily
    2. XM_030247489.2XP_030103349.1  formin-binding protein 1 isoform X8

      UniProtKB/TrEMBL
      A2AQ42
      Conserved Domains (3) summary
      cd07676
      Location:5257
      F-BAR_FBP17; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Formin Binding Protein 17
      cl00087
      Location:401477
      HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases
      cl17036
      Location:548604
      SH3; Src Homology 3 domain superfamily
    3. XM_006497686.3XP_006497749.1  formin-binding protein 1 isoform X3

      UniProtKB/TrEMBL
      A2AQ42
      Conserved Domains (3) summary
      cd07676
      Location:5257
      F-BAR_FBP17; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Formin Binding Protein 17
      cd12071
      Location:580636
      SH3_FBP17; Src Homology 3 domain of Formin Binding Protein 17
      cl00087
      Location:434510
      HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases
    4. XM_006497685.3XP_006497748.1  formin-binding protein 1 isoform X2

      UniProtKB/TrEMBL
      A2AQ42
      Conserved Domains (3) summary
      cd07676
      Location:5257
      F-BAR_FBP17; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Formin Binding Protein 17
      cd12071
      Location:581637
      SH3_FBP17; Src Homology 3 domain of Formin Binding Protein 17
      cl00087
      Location:434510
      HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases
    5. XM_006497695.5XP_006497758.1  formin-binding protein 1 isoform X16

      UniProtKB/TrEMBL
      A2AQ42
      Conserved Domains (3) summary
      cd07676
      Location:5257
      F-BAR_FBP17; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Formin Binding Protein 17
      cd12071
      Location:552608
      SH3_FBP17; Src Homology 3 domain of Formin Binding Protein 17
      cl00087
      Location:406482
      HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases
    6. XM_006497691.5XP_006497754.1  formin-binding protein 1 isoform X11

      UniProtKB/TrEMBL
      A2AQ42
      Conserved Domains (3) summary
      cd07676
      Location:5257
      F-BAR_FBP17; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Formin Binding Protein 17
      cd12071
      Location:581637
      SH3_FBP17; Src Homology 3 domain of Formin Binding Protein 17
      cl00087
      Location:434510
      HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases
    7. XM_006497690.3XP_006497753.1  formin-binding protein 1 isoform X7

      UniProtKB/TrEMBL
      A2AQ41, A2AQ42
      Related
      ENSMUSP00000097782.3, ENSMUST00000100208.9
      Conserved Domains (3) summary
      cd07676
      Location:5257
      F-BAR_FBP17; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Formin Binding Protein 17
      cl00087
      Location:401477
      HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases
      cl17036
      Location:547603
      SH3; Src Homology 3 domain superfamily
    8. XM_006497689.3XP_006497752.1  formin-binding protein 1 isoform X6

      UniProtKB/TrEMBL
      A2AQ42
      Conserved Domains (3) summary
      cd07676
      Location:5257
      F-BAR_FBP17; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Formin Binding Protein 17
      cl00087
      Location:401477
      HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases
      cl17036
      Location:548604
      SH3; Src Homology 3 domain superfamily
    9. XM_006497687.3XP_006497750.1  formin-binding protein 1 isoform X4

      UniProtKB/TrEMBL
      A2AQ42
      Conserved Domains (3) summary
      cd07676
      Location:5257
      F-BAR_FBP17; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Formin Binding Protein 17
      cd12071
      Location:553609
      SH3_FBP17; Src Homology 3 domain of Formin Binding Protein 17
      cl00087
      Location:406482
      HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases
    10. XM_006497684.3XP_006497747.1  formin-binding protein 1 isoform X1

      UniProtKB/TrEMBL
      A2AQ42
      Conserved Domains (3) summary
      cd07676
      Location:5257
      F-BAR_FBP17; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Formin Binding Protein 17
      cd12071
      Location:580636
      SH3_FBP17; Src Homology 3 domain of Formin Binding Protein 17
      cl00087
      Location:434510
      HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases
    11. XM_006497694.3XP_006497757.1  formin-binding protein 1 isoform X15

      UniProtKB/TrEMBL
      A2AQ42, A2AQ43
      Related
      ENSMUSP00000109188.2, ENSMUST00000073879.12
      Conserved Domains (3) summary
      cd07676
      Location:5257
      F-BAR_FBP17; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Formin Binding Protein 17
      cl00087
      Location:340416
      HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases
      cl17036
      Location:486542
      SH3; Src Homology 3 domain superfamily
    12. XM_006497693.3XP_006497756.1  formin-binding protein 1 isoform X14

      UniProtKB/TrEMBL
      A2AQ42
      Conserved Domains (3) summary
      cd07676
      Location:5257
      F-BAR_FBP17; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Formin Binding Protein 17
      cl00087
      Location:340416
      HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases
      cl17036
      Location:487543
      SH3; Src Homology 3 domain superfamily
    13. XM_017315551.3XP_017171040.1  formin-binding protein 1 isoform X13

      UniProtKB/TrEMBL
      A2AQ42, A2AQ44
      Related
      ENSMUSP00000097781.3, ENSMUST00000100207.9
      Conserved Domains (3) summary
      cd07676
      Location:5257
      F-BAR_FBP17; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Formin Binding Protein 17
      cl00087
      Location:345421
      HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases
      cl17036
      Location:491547
      SH3; Src Homology 3 domain superfamily
    14. XM_006497692.3XP_006497755.1  formin-binding protein 1 isoform X12

      UniProtKB/TrEMBL
      A2AQ42
      Conserved Domains (3) summary
      cd07676
      Location:5257
      F-BAR_FBP17; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Formin Binding Protein 17
      cl00087
      Location:345421
      HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases
      cl17036
      Location:492548
      SH3; Src Homology 3 domain superfamily
    15. XM_030247491.2XP_030103351.1  formin-binding protein 1 isoform X10

      UniProtKB/TrEMBL
      A2AQ42, A2AQ45
      Related
      ENSMUSP00000109184.2, ENSMUST00000113555.8
      Conserved Domains (3) summary
      cd07676
      Location:5257
      F-BAR_FBP17; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Formin Binding Protein 17
      cl00087
      Location:377453
      HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases
      cl17036
      Location:523579
      SH3; Src Homology 3 domain superfamily
    16. XM_006497688.3XP_006497751.1  formin-binding protein 1 isoform X5

      UniProtKB/TrEMBL
      A2AQ42
      Conserved Domains (3) summary
      cd07676
      Location:5257
      F-BAR_FBP17; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Formin Binding Protein 17
      cl00087
      Location:405481
      HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases
      cl17036
      Location:552608
      SH3; Src Homology 3 domain superfamily
    17. XM_036158324.1XP_036014217.1  formin-binding protein 1 isoform X17

      Conserved Domains (3) summary
      cd11629
      Location:277353
      HR1_FBP17; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Formin Binding Protein 17
      cd12071
      Location:424480
      SH3_FBP17; Src Homology 3 domain of Formin Binding Protein 17
      cl12013
      Location:1100
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    RNA

    1. XR_374060.4 RNA Sequence