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    Fut11 fucosyltransferase 11 [ Mus musculus (house mouse) ]

    Gene ID: 73068, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Fut11provided by MGI
    Official Full Name
    fucosyltransferase 11provided by MGI
    Primary source
    MGI:MGI:1920318
    See related
    Ensembl:ENSMUSG00000039357 AllianceGenome:MGI:1920318
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    3110009G03Rik
    Summary
    Predicted to enable alpha-(1->3)-fucosyltransferase activity. Predicted to be involved in N-glycan fucosylation. Predicted to be located in Golgi cisterna membrane and Golgi membrane. Human ortholog(s) of this gene implicated in stomach cancer. Orthologous to human FUT11 (fucosyltransferase 11). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in ovary adult (RPKM 33.9), adrenal adult (RPKM 32.8) and 22 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Fut11 in Genome Data Viewer
    Location:
    14 A3; 14 11.53 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (20745036..20750265)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (20694968..20700197)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7297 Neighboring gene synaptopodin 2-like Neighboring gene STARR-seq mESC enhancer starr_36115 Neighboring gene SEC24 homolog C, COPII coat complex component Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:21501696-21501849 Neighboring gene microRNA 6946 Neighboring gene RIKEN cDNA 6230400D17 gene Neighboring gene predicted gene, 25328 Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Dry and wet experiments reveal the significant role of FUT11 in clear cell renal cell carcinoma. Zhang P, et al. Int Immunopharmacol, 2022 Dec. PMID 36403525
    2. Comparison of human and mouse Fuc-TX and Fuc-TXI genes, and expression studies in the mouse. Baboval T, et al. Mamm Genome, 2002 Sep. PMID 12370785
    3. Composition of Drosophila melanogaster proteome involved in fucosylated glycan metabolism. Roos C, et al. J Biol Chem, 2002 Feb 1. PMID 11698403
    4. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
    5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Dry and wet experiments reveal the significant role of FUT11 in clear cell renal cell carcinoma.
      Title: Dry and wet experiments reveal the significant role of FUT11 in clear cell renal cell carcinoma.
    2. amino acid sequence and expression
      Title: Comparison of human and mouse Fuc-TX and Fuc-TXI genes, and expression studies in the mouse.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables alpha-(1->3)-fucosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alpha-(1->3)-fucosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables fucosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables fucosyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in N-glycan fucosylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in N-glycan fucosylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in fucosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi cisterna membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    alpha-(1,3)-fucosyltransferase 11
    Names
    fuc-TXI
    fucT-XI
    fucosyltransferase XI
    galactoside 3-L-fucosyltransferase 11
    NP_082704.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028428.2 → NP_082704.1  alpha-(1,3)-fucosyltransferase 11 precursor

      See identical proteins and their annotated locations for NP_082704.1

      Status: PROVISIONAL

      Source sequence(s)
      AC121599
      Consensus CDS
      CCDS26851.1
      UniProtKB/Swiss-Prot
      Q8BHC9, Q9CXS9
      UniProtKB/TrEMBL
      B2RRR9
      Related
      ENSMUSP00000040370.2, ENSMUST00000048016.3
      Conserved Domains (2) summary
      pfam00852
      Location:212 → 351
      Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
      pfam17039
      Location:115 → 176
      Glyco_tran_10_N; Fucosyltransferase, N-terminal

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      20745036..20750265
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BHC9.1 GenPept UniProtKB/Swiss-Prot:Q8BHC9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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