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    Usp20 ubiquitin specific peptidase 20 [ Mus musculus (house mouse) ]

    Gene ID: 74270, updated on 9-Dec-2024

    Summary

    Official Symbol
    Usp20provided by MGI
    Official Full Name
    ubiquitin specific peptidase 20provided by MGI
    Primary source
    MGI:MGI:1921520
    See related
    Ensembl:ENSMUSG00000026854 AllianceGenome:MGI:1921520
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Vdu2; 1700055M05Rik
    Summary
    Predicted to enable G protein-coupled receptor binding activity; cysteine-type deubiquitinase activity; and cysteine-type endopeptidase activity. Predicted to be involved in several processes, including antiviral innate immune response; protein deubiquitination; and regulation of signal transduction. Predicted to be located in centrosome. Is expressed in ganglia; retina; and trigeminal nerve. Orthologous to human USP20 (ubiquitin specific peptidase 20). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 28.5), genital fat pad adult (RPKM 18.2) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Usp20 in Genome Data Viewer
    Location:
    2 B; 2 21.77 cM
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (30872291..30912667)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (30982279..31022655)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene torsin family 1, member B Neighboring gene torsin family 1, member A (torsin A) Neighboring gene cDNA sequence BC005624 Neighboring gene predicted gene, 39786 Neighboring gene formin binding protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E9195 Neighboring gene STARR-positive B cell enhancer ABC_E4431 Neighboring gene STARR-seq mESC enhancer starr_04135 Neighboring gene STARR-positive B cell enhancer ABC_E4432 Neighboring gene STARR-positive B cell enhancer ABC_E9196 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:30971715-30971947 Neighboring gene STARR-positive B cell enhancer ABC_E5904 Neighboring gene RIKEN cDNA D330023K18 gene Neighboring gene G protein-coupled receptor 107

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (9)  1 citation
    • Gene trapped (1) 
    • Targeted (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables G protein-coupled receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables cysteine-type deubiquitinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables cysteine-type deubiquitinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables cysteine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables cysteine-type endopeptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in antiviral innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in antiviral innate immune response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in endocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of canonical NF-kappaB signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in nervous system development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of autophagy IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of autophagy ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein K48-linked deubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein K48-linked deubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein K63-linked deubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein K63-linked deubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein deubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein deubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of G protein-coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in centrosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    ubiquitin carboxyl-terminal hydrolase 20
    Names
    VHL-interacting deubiquitinating enzyme 2
    deubiquitinating enzyme 20
    ubiquitin specific protease 20
    ubiquitin thioesterase 20
    ubiquitin thiolesterase 20
    ubiquitin-specific-processing protease 20
    NP_083122.1
    XP_030107995.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028846.5NP_083122.1  ubiquitin carboxyl-terminal hydrolase 20

      See identical proteins and their annotated locations for NP_083122.1

      Status: VALIDATED

      Source sequence(s)
      AK047242, AK054279, AK173083, BY251374
      Consensus CDS
      CCDS15893.1
      UniProtKB/Swiss-Prot
      Q69ZT5, Q8C6M1, Q8CJ72
      Related
      ENSMUSP00000099913.5, ENSMUST00000102849.11
      Conserved Domains (4) summary
      smart00695
      Location:812896
      DUSP; Domain in ubiquitin-specific proteases
      COG5560
      Location:73688
      UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
      pfam00443
      Location:145684
      UCH; Ubiquitin carboxyl-terminal hydrolase
      pfam02148
      Location:3090
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      30872291..30912667
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030252135.1XP_030107995.1  ubiquitin carboxyl-terminal hydrolase 20 isoform X1

      UniProtKB/Swiss-Prot
      Q69ZT5, Q8C6M1, Q8CJ72
      Conserved Domains (4) summary
      smart00695
      Location:812896
      DUSP; Domain in ubiquitin-specific proteases
      COG5560
      Location:73688
      UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
      pfam00443
      Location:145684
      UCH; Ubiquitin carboxyl-terminal hydrolase
      pfam02148
      Location:3090
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein