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    queF 7-cyano-7-deazaguanine reductase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947270, updated on 3-Dec-2024

    Summary

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    Official Symbol
    queF
    Official Full Name
    7-cyano-7-deazaguanine reductase
    Primary source
    ECOCYC:G7452
    Locus tag
    b2794
    See related
    ASAP:ABE-0009162
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2789; yqcD
    Summary
    Asn, Asp, Tyr, and His tRNA GUN anticodons are modified by queuosine at the G. [More information is available at EcoGene: EG13173]. QueF catalyzes a later step of queuosine biosynthesis, the formation of preQ1 from preQ0 . [More information is available at EcoCyc: G7452].
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    Genomic context

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    Sequence:
    NC_000913.3 (2925348..2926196)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene SecY-interacting protein Neighboring gene nucleotide 5'-monophosphate nucleosidase Neighboring gene L-serine:H(+) symporter SdaC

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Expression and characterization of the nitrile reductase queF from E. coli. Moeller K, et al. Enzyme Microb Technol, 2013 Mar 5. PMID 23410922
    2. Kinetic Analysis and Probing with Substrate Analogues of the Reaction Pathway of the Nitrile Reductase QueF from Escherichia coli. Jung J, et al. J Biol Chem, 2016 Dec 2. PMID 27754868, Free PMC Article
    3. Three-dimensional structure of hyper-modified nucleoside Q located in the wobbling position of tRNA. Yokoyama S, et al. Nature, 1979 Nov 1. PMID 388227
    4. Structure of the modified nucleoside Q isolated from Escherichia coli transfer ribonucleic acid. 7-(4,5-cis-Dihydroxy-1-cyclopenten-3-ylaminomethyl)-7-deazaguanosine. Kasai H, et al. Biochemistry, 1975 Sep 23. PMID 1101947
    5. Possible anticodon sequences of tRNA His , tRNA Asm , and tRNA Asp from Escherichia coli B. Universal presence of nucleoside Q in the first postion of the anticondons of these transfer ribonucleic acids. Harada F, et al. Biochemistry, 1972 Jan 18. PMID 4550561

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A model of QueF substrate recognition and a catalytic pathway for the enzyme are proposed based on these data.
      Title: Kinetic Analysis and Probing with Substrate Analogues of the Reaction Pathway of the Nitrile Reductase QueF from Escherichia coli.
    2. The expression of NP-417272 after cloning in E coli BL21 cells was studied, and optimal conditions for its activity toward its natural substrate were determined.
      Title: Expression and characterization of the nitrile reductase queF from E. coli.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables preQ1 synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables preQ1 synthase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables preQ1 synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in queuosine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in queuosine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within queuosine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tRNA modification IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    7-cyano-7-deazaguanine reductase
    NP_417274.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2925348..2926196
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417274.1 7-cyano-7-deazaguanine reductase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417274.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8S0FM31
      Conserved Domains (1) summary
      PRK11792
      Location:9 → 282
      queF; 7-cyano-7-deazaguanine reductase; Provisional
    Nucleotide Protein
    Heading Accession and Version

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