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    luxS S-ribosylhomocysteine lyase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947168, updated on 3-Dec-2024

    Summary

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    Official Symbol
    luxS
    Official Full Name
    S-ribosylhomocysteine lyase
    Primary source
    ECOCYC:EG12712
    Locus tag
    b2687
    See related
    ASAP:ABE-0008842
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2681; ygaG
    Summary
    Escherichia coli luxS is capable of inducing V. harveyi luminescence. [More information is available at EcoGene: EG12712]. LuxS is involved in biosynthesis of autoinducer, the hormone-like signal that mediates cell-cell communication during quorum sensing, the response to increased cell density . [More information is available at EcoCyc: EG12712].
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    Genomic context

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    Sequence:
    NC_000913.3 (2814218..2814733, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene multidrug efflux pump membrane fusion protein EmrA Neighboring gene multidrug efflux pump membrane subunit EmrB Neighboring gene ncRNA Neighboring gene glutamate--cysteine ligase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Quorum-sensing gene luxS regulates flagella expression and Shiga-like toxin production in F18ab Escherichia coli. Yang Y, et al. Can J Microbiol, 2014 Jun. PMID 24848979
    2. S-ribosylhomocysteine cleavage enzyme from Escherichia coli. Miller CH, et al. J Biol Chem, 1968 Jan 10. PMID 4867478
    3. Quorum sensing in Escherichia coli and Salmonella typhimurium. Surette MG, et al. Proc Natl Acad Sci U S A, 1998 Jun 9. PMID 9618536, Free PMC Article
    4. LuxS: its role in central metabolism and the in vitro synthesis of 4-hydroxy-5-methyl-3(2H)-furanone. Winzer K, et al. Microbiology (Reading), 2002 Apr. PMID 11932438
    5. Bacterial cell-to-cell communication: sorry, can't talk now - gone to lunch! Winzer K, et al. Curr Opin Microbiol, 2002 Apr. PMID 11934621

    See all (59) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Expression of Meiothermus ruber luxS in E. coli alters the antibiotic susceptibility and biofilm formation.
      Title: Expression of Meiothermus ruber luxS in E. coli alters the antibiotic susceptibility and biofilm formation.
    2. study demonstrated that luxS affects the expression of flagella and Stx2e toxin, 2 important STEC virulence factors
      Title: Quorum-sensing gene luxS regulates flagella expression and Shiga-like toxin production in F18ab Escherichia coli.
    3. LuxS contributes to virulence in avian pathogenic Escherichia coli O78:K80:H9.
      Title: LuxS contributes to virulence in avian pathogenic Escherichia coli O78:K80:H9.
    4. Proteomic profiling of luxS mutants showed only a few proteins were differentially expressed and those that were altered suggested a metabolic rather than communication role for the E. coli luxS gene product.
      Title: Mutation design and strain background influence the phenotype of Escherichia coli luxS mutants.
    5. Deletion of the luxS gene reduced the bacterial virulence by 31.5-fold in ducklings.
      Title: The luxS gene functions in the pathogenesis of avian pathogenic Escherichia coli.
    6. Polyphosphate degradation in stationary phase triggers biofilm formation via LuxS quorum sensing system in Escherichia coli.
      Title: Polyphosphate degradation in stationary phase triggers biofilm formation via LuxS quorum sensing system in Escherichia coli.
    7. Pfs and LuxS synthesize AI-2 in vitro from S-ribosylhomocysteine.
      Title: [Cloning and expression of luxS and pfs and in vitro biosynthesis autoinducer 2 of avian pathogenic Escherichia coli from Anhui Province].
    8. luxS deletion significantly increases swimming motility and flagella synthesis in Escherichia coli K12.
      Title: The absence of the luxS gene increases swimming motility and flagella synthesis in Escherichia coli K12.
    9. Culture supernatants of E. coli and Staphylococcus aureus luxS mutants were found not to contain detectable levels of AI-2 activity.
      Title: LuxS-independent formation of AI-2 from ribulose-5-phosphate.
    10. N-terminus verified by Edman degradation on mature peptide
      Title: Comparing the predicted and observed properties of proteins encoded in the genome of Escherichia coli K-12.
    Submit: New GeneRIF Correction See all GeneRIFs (12)

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables S-ribosylhomocysteine lyase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables S-ribosylhomocysteine lyase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables S-ribosylhomocysteine lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables S-ribosylhomocysteine lyase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in L-methionine salvage from S-adenosylmethionine IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within L-methionine salvage from S-adenosylmethionine IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in quorum sensing IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within quorum sensing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    S-ribosylhomocysteine lyase
    NP_417172.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2814218..2814733 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417172.1 S-ribosylhomocysteine lyase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417172.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A5B9ARD5
      Conserved Domains (1) summary
      PRK02260
      Location:1 → 161
      PRK02260; S-ribosylhomocysteine lyase
    Nucleotide Protein
    Heading Accession and Version

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