Tmem100 transmembrane protein 100 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tmem100provided by MGI
Official Full Name: transmembrane protein 100provided by MGI
Primary source: MGI:MGI:1915138
See related: Ensembl:ENSMUSG00000069763 AllianceGenome:MGI:1915138
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 1810057C19Rik
Summary: Involved in positive regulation of endothelial cell differentiation; positive regulation of vasculogenesis; and regulation of sensory perception of pain. Acts upstream of or within several processes, including Notch signaling pathway; circulatory system development; and regulation of intracellular signal transduction. Located in perikaryon; perinuclear region of cytoplasm; and plasma membrane. Is expressed in several structures, including cardiovascular system; eye; genitourinary system; hemolymphoid system gland; and spinal cord. Orthologous to human TMEM100 (transmembrane protein 100). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in lung adult (RPKM 79.8), subcutaneous fat pad adult (RPKM 7.4) and 3 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 C; 11 54.75 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (89921174..89927334)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (90030348..90036508)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Tmem100-BAC-EGFP mice to selectively mark and purify embryonic endothelial cells of large caliber arteries in mid-gestational vascular formation.
Title: Tmem100-BAC-EGFP mice to selectively mark and purify embryonic endothelial cells of large caliber arteries in mid-gestational vascular formation.
TMEM100 is a key factor for specification of lymphatic endothelial progenitors.
Title: TMEM100 is a key factor for specification of lymphatic endothelial progenitors.
Tmem100 is a potential regulator of kidney development by related to BMP signal transduction in the process of metanephric mesenchymal-cell-to-epithelial transition.BMP 7 is a key regulator of Tmem100-mediated cell proliferation in metanephric mesenchymal cells.There is a complicated regulation network among Tmem100, BMP7, and BMPR-II in mouse embryonic kidney-derived cells.
Title: BMP7 plays a critical role in TMEM100-inhibited cell proliferation and apoptosis in mouse metanephric mesenchymal cells in vitro.
TMEM100 has essential functions for the maintenance of vascular integrity as well as the formation of blood vessels.
Title: Essential role for TMEM100 in vascular integrity but limited contributions to the pathogenesis of hereditary haemorrhagic telangiectasia.
The Tmem100 deficiency causes EndMT defect during AVC cushion formation possibly via disturbance of multiple calcium-related signaling events.
Title: Impairment of endothelial-mesenchymal transformation during atrioventricular cushion formation in Tmem100 null embryos.
This study demonistrated that Tmem100 Is a Regulator of TRPA1-TRPV1 Complex and Contributes to Persistent Pain in mice.
Title: Tmem100 Is a Regulator of TRPA1-TRPV1 Complex and Contributes to Persistent Pain.
This study demonistrated that TMEM100 is a novel, membrane-associated marker for enteric nerves and is as effective as PGP9.5 for identifying neuronal structures in the gastrointestinal tract.
Title: Distribution of TMEM100 in the mouse and human gastrointestinal tract--a novel marker of enteric nerves.
TMEM100 may play indispensable roles downstream of BMP9/BMP10-ALK1 signaling during endothelial differentiation and vascular morphogenesis.
Title: Tmem100, an ALK1 receptor signaling-dependent gene essential for arterial endothelium differentiation and vascular morphogenesis.
Tmem100 was predominantly expressed in arterial endothelial cells of developing embryos.
Title: Generation of mice with a conditional and reporter allele for Tmem100.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (9) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in BMP signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in BMP signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in BMP signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within Notch signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within arterial endothelial cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to BMP stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to BMP stimulus	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within endocardial cushion development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within epithelial to mesenchymal transition involved in endocardial cushion formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within in utero embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of endothelial cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of vasculogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of calcium-mediated signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of sensory perception of pain	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of sensory perception of pain	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within vasculogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
located_in perikaryon	IDA Inferred from Direct Assay more info	PubMed
located_in perikaryon	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: transmembrane protein 100

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_026433.2 → NP_080709.1 transmembrane protein 100

See identical proteins and their annotated locations for NP_080709.1

Status: PROVISIONAL

Source sequence(s)

AK007878

Consensus CDS

CCDS25239.1

UniProtKB/Swiss-Prot

Q9CQG9

Related

ENSMUSP00000090464.4, ENSMUST00000092788.4

Conserved Domains (1) summary

pfam16311
Location:1 → 133

TMEM100; Transmembrane protein 100

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

89921174..89927334

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006534031.2 → XP_006534094.1 transmembrane protein 100 isoform X1

See identical proteins and their annotated locations for XP_006534094.1

UniProtKB/Swiss-Prot

Q9CQG9

Conserved Domains (1) summary

pfam16311
Location:1 → 133

TMEM100; Transmembrane protein 100
XM_006534030.5 → XP_006534093.1 transmembrane protein 100 isoform X1

See identical proteins and their annotated locations for XP_006534093.1

UniProtKB/Swiss-Prot

Q9CQG9

Conserved Domains (1) summary

pfam16311
Location:1 → 133

TMEM100; Transmembrane protein 100
XM_036156923.1 → XP_036012816.1 transmembrane protein 100 isoform X1

UniProtKB/Swiss-Prot

Q9CQG9

Conserved Domains (1) summary

pfam16311
Location:1 → 133

TMEM100; Transmembrane protein 100