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    Chtf18 CTF18, chromosome transmission fidelity factor 18 [ Mus musculus (house mouse) ]

    Gene ID: 214901, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Chtf18provided by MGI
    Official Full Name
    CTF18, chromosome transmission fidelity factor 18provided by MGI
    Primary source
    MGI:MGI:2384887
    See related
    Ensembl:ENSMUSG00000019214 AllianceGenome:MGI:2384887
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CTF18; Chl12; 6030457M03Rik
    Summary
    Predicted to enable DNA binding activity. Predicted to contribute to DNA clamp loader activity and single-stranded DNA helicase activity. Acts upstream of or within germ cell development; meiotic nuclear division; and negative regulation of chromosome segregation. Located in cytoplasm and male germ cell nucleus. Is expressed in several structures, including brain; genitourinary system; gut; immune system; and integumental system. Orthologous to human CHTF18 (chromosome transmission fidelity factor 18). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in thymus adult (RPKM 10.4), CNS E11.5 (RPKM 10.3) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Chtf18 in Genome Data Viewer
    Location:
    17 A3.3; 17 12.83 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (25938004..25946409, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (25719030..25727434, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930541O19 gene Neighboring gene NSA2 ribosome biogenesis homolog pseudogene Neighboring gene guanine nucleotide binding protein (G protein), gamma 13 Neighboring gene STARR-positive B cell enhancer ABC_E3190 Neighboring gene RNA pseudouridylate synthase domain containing 1 Neighboring gene mesothelin-like Neighboring gene mesothelin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Germline expression of mammalian CTF18, an evolutionarily conserved protein required for germ cell proliferation in the fly and sister chromatid cohesion in yeast. Berkowitz KM, et al. Mol Hum Reprod, 2008 Mar. PMID 18250106
    2. CHTF18 ensures the quantity and quality of the ovarian reserve†. Holton RA, et al. Biol Reprod, 2020 Jun 23. PMID 32219340, Free PMC Article
    3. Disruption of CHTF18 causes defective meiotic recombination in male mice. Berkowitz KM, et al. PLoS Genet, 2012. PMID 23133398, Free PMC Article
    4. Multiple roles of FOXJ3 in spermatogenesis: A lesson from Foxj3 conditional knockout mouse models. Ni L, et al. Mol Reprod Dev, 2016 Dec. PMID 27739607
    5. Molecular Profiling Reveals Involvement of ESCO2 in Intermediate Progenitor Cell Maintenance in the Developing Mouse Cortex. Ulmke PA, et al. Stem Cell Reports, 2021 Apr 13. PMID 33798452, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC38008

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to DNA clamp loader activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to DNA clamp loader activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    contributes_to DNA clamp loader activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    contributes_to single-stranded DNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to single-stranded DNA helicase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    contributes_to single-stranded DNA helicase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA duplex unwinding IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within germ cell development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within male meiotic nuclear division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of DNA-directed DNA polymerase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-directed DNA polymerase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within reciprocal meiotic recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Ctf18 RFC-like complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of Ctf18 RFC-like complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in male germ cell nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    chromosome transmission fidelity protein 18 homolog
    Names
    CTF18, chromosome transmission fidelity factor 18 homolog
    Chl12 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145409.2 → NP_663384.2  chromosome transmission fidelity protein 18 homolog

      See identical proteins and their annotated locations for NP_663384.2

      Status: VALIDATED

      Source sequence(s)
      AK077947, BB861615, BC083096
      Consensus CDS
      CCDS28523.1
      UniProtKB/Swiss-Prot
      Q8BIW9, Q8R1R7
      UniProtKB/TrEMBL
      A0A0R4J0I4
      Related
      ENSMUSP00000043896.8, ENSMUST00000048054.14
      Conserved Domains (2) summary
      cd00009
      Location:347 → 516
      AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
      cl19912
      Location:486 → 553
      DNA_pol3_delta; DNA polymerase III, delta subunit

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      25938004..25946409 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006524017.5 → XP_006524080.1  chromosome transmission fidelity protein 18 homolog isoform X1

      UniProtKB/Swiss-Prot
      Q8BIW9, Q8R1R7
      UniProtKB/TrEMBL
      E9PVJ3
      Related
      ENSMUSP00000131768.3, ENSMUST00000170070.3
      Conserved Domains (1) summary
      PRK04195
      Location:343 → 589
      PRK04195; replication factor C large subunit; Provisional

    2. XM_030249640.2 → XP_030105500.1  chromosome transmission fidelity protein 18 homolog isoform X2

      Conserved Domains (1) summary
      PRK04195
      Location:1 → 196
      PRK04195; replication factor C large subunit; Provisional
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BIW9.2 GenPept UniProtKB/Swiss-Prot:Q8BIW9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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