gnd 6-phosphogluconate dehydrogenase, decarboxylating [Escherichia coli str. K-12 substr. MG1655] - Gene

Summary

Official Symbol: gnd
Official Full Name: 6-phosphogluconate dehydrogenase, decarboxylating
Primary source: ECOCYC:EG10411
Locus tag: b2029
See related: ASAP:ABE-0006737
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage: Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as: ECK2024
Summary: A null mutation in the gnd gene encoding 6-phosphogluconate dehydrogenase does not affect the growth rate significantly. [More information is available at EcoCyc: EG10411].
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NC_000913.3 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

The enzyme responsible for the TeO3(2-) toxicant reduction was identified as 6-phosphogluconate dehydrogenase (Gnd).
Title: Escherichia coli 6-phosphogluconate dehydrogenase aids in tellurite resistance by reducing the toxicant in a NADPH-dependent manner.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables NADP binding	IBA Inferred from Biological aspect of Ancestor more info
enables NADP binding	IEA Inferred from Electronic Annotation more info
enables guanosine tetraphosphate binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	IEA Inferred from Electronic Annotation more info
enables phosphogluconate dehydrogenase (decarboxylating) activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphogluconate dehydrogenase (decarboxylating) activity	IDA Inferred from Direct Assay more info	PubMed
enables phosphogluconate dehydrogenase (decarboxylating) activity	IEA Inferred from Electronic Annotation more info
enables phosphogluconate dehydrogenase (decarboxylating) activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed
enables protein homodimerization activity	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in D-gluconate catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within D-gluconate catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in D-gluconate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in organic acid catabolic process	IEA Inferred from Electronic Annotation more info
involved_in pentose-phosphate shunt	IDA Inferred from Direct Assay more info	PubMed
involved_in pentose-phosphate shunt	IEA Inferred from Electronic Annotation more info
involved_in pentose-phosphate shunt, oxidative branch	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed

NP_416533.1

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The following sections contain reference sequences that belong to a specific genome build. Explain