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    nanT N-acetylneuraminate:H(+) symporter [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947740, updated on 3-Dec-2024

    Summary

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    Official Symbol
    nanT
    Official Full Name
    N-acetylneuraminate:H(+) symporter
    Primary source
    ECOCYC:G436
    Locus tag
    b3224
    See related
    ASAP:ABE-0010577
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3213
    Summary
    Major Facilitator Superfamily (MFS). [More information is available at EcoGene: EG20145]. NanT is a probable sialic acid transporter. [More information is available at EcoCyc: G436].
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    Genomic context

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    Sequence:
    NC_000913.3 (3371084..3372574, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene N-acetylneuraminate anomerase Neighboring gene N-acetylmannosamine kinase Neighboring gene putative N-acetylmannosamine-6-phosphate 2-epimerase Neighboring gene N-acetylneuraminate lyase Neighboring gene NanR

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Uptake of N-acetylneuraminic acid by Escherichia coli K-235. Biochemical characterization of the transport system. Rodríguez-Aparicio LB, et al. Biochem J, 1987 Sep 1. PMID 2825630, Free PMC Article
    2. The sialic acid transporter NanT is necessary and sufficient for uptake of 3-deoxy-d-manno-oct-2-ulosonic acid (Kdo) and its azido analog in Escherichia coli. Nilsson I, et al. Mol Microbiol, 2018 Oct. PMID 30076772
    3. Identification of an inducible catabolic system for sialic acids (nan) in Escherichia coli. Vimr ER, et al. J Bacteriol, 1985 Nov. PMID 3902799, Free PMC Article
    4. Derived structure of the putative sialic acid transporter from Escherichia coli predicts a novel sugar permease domain. Martinez J, et al. J Bacteriol, 1995 Oct. PMID 7592358, Free PMC Article
    5. Complete nucleotide sequence of the E. coli N-acetylneuraminate lyase. Ohta Y, et al. Nucleic Acids Res, 1985 Dec 20. PMID 3909108, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The sialic acid transporter NanT is the major E. coli 3-deoxy-d-manno-oct-2-ulosonic acid and its azido analog uptake mechanism.
      Title: The sialic acid transporter NanT is necessary and sufficient for uptake of 3-deoxy-d-manno-oct-2-ulosonic acid (Kdo) and its azido analog in Escherichia coli.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables carboxylic acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sialic acid transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sialic acid:proton symporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sialic acid:proton symporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in carboxylic acid transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in carboxylic acid transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within sialic acid transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in sialic acid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    N-acetylneuraminate:H(+) symporter

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3371084..3372574 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417691.4 N-acetylneuraminate:H(+) symporter [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417691.4

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A6D0IBD6, A0AAN5ZJP1
      Conserved Domains (1) summary
      PRK03893
      Location:1 → 496
      PRK03893; putative sialic acid transporter; Provisional
    Nucleotide Protein
    Heading Accession and Version

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