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    Slc25a38 solute carrier family 25, member 38 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 301067, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Slc25a38provided by RGD
    Official Full Name
    solute carrier family 25, member 38provided by RGD
    Primary source
    RGD:1311914
    See related
    EnsemblRapid:ENSRNOG00000018552 AllianceGenome:RGD:1311914
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1311914
    Summary
    Predicted to enable glycine transmembrane transporter activity. Predicted to be involved in erythrocyte differentiation and glycine import into mitochondrion. Predicted to be located in mitochondrial inner membrane. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in autosomal recessive pyridoxine-refractory sideroblastic anemia 2. Orthologous to human SLC25A38 (solute carrier family 25 member 38). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 83.3), Spleen (RPKM 57.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Slc25a38 in Genome Data Viewer
    Location:
    8q32
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (128713180..128725968)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (119835546..119848334)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (128790348..128802988)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480114 Neighboring gene C-X3-C motif chemokine receptor 1 Neighboring gene C-C motif chemokine receptor 8 Neighboring gene small nucleolar RNA, H/ACA box 73B like 1 Neighboring gene small nucleolar RNA, H/ACA box 6 Neighboring gene ribosomal protein SA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Characterization of Human and Yeast Mitochondrial Glycine Carriers with Implications for Heme Biosynthesis and Anemia. Lunetti P, et al. J Biol Chem, 2016 Sep 16. PMID 27476175, Free PMC Article
    2. Mutations in mitochondrial carrier family gene SLC25A38 cause nonsyndromic autosomal recessive congenital sideroblastic anemia. Guernsey DL, et al. Nat Genet, 2009 Jun. PMID 19412178
    3. Synthesis, delivery and regulation of eukaryotic heme and Fe-S cluster cofactors. Barupala DP, et al. Arch Biochem Biophys, 2016 Feb 15. PMID 26785297, Free PMC Article
    4. Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context. Morgenstern M, et al. Cell Metab, 2021 Dec 7. PMID 34800366, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC124671

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables glycine transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glycine transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycine transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in erythrocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in erythrocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in erythrocyte differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in glycine import into mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycine import into mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glycine import into mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial inner membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    mitochondrial glycine transporter

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001030032.2 → NP_001025203.2  mitochondrial glycine transporter

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/Swiss-Prot
      G3V8E7, Q499U1
      UniProtKB/TrEMBL
      A0A8L2QD79
      Related
      ENSRNOP00000025142.6, ENSRNOT00000025142.8
      Conserved Domains (1) summary
      pfam00153
      Location:46 → 137
      Mito_carr; Mitochondrial carrier protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      128713180..128725968
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039081302.2 → XP_038937230.1  mitochondrial glycine transporter isoform X2

      Conserved Domains (1) summary
      pfam00153
      Location:51 → 134
      Mito_carr; Mitochondrial carrier protein

    2. XM_006244089.5 → XP_006244151.1  mitochondrial glycine transporter isoform X1

      UniProtKB/TrEMBL
      A0A0G2K0U7, A0A8L2QD79
      Related
      ENSRNOP00000071588.1, ENSRNOT00000083329.3
      Conserved Domains (2) summary
      PTZ00169
      Location:30 → 297
      PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
      pfam00153
      Location:25 → 116
      Mito_carr; Mitochondrial carrier protein

    3. XM_039081301.2 → XP_038937229.1  mitochondrial glycine transporter isoform X2

      Conserved Domains (1) summary
      pfam00153
      Location:51 → 134
      Mito_carr; Mitochondrial carrier protein

    4. XM_039081304.2 → XP_038937232.1  mitochondrial glycine transporter isoform X3

      UniProtKB/TrEMBL
      A6I3Z2
      Conserved Domains (1) summary
      pfam00153
      Location:89 → 176
      Mito_carr; Mitochondrial carrier protein

    5. XM_039081305.2 → XP_038937233.1  mitochondrial glycine transporter isoform X3

      UniProtKB/TrEMBL
      A6I3Z2
      Conserved Domains (1) summary
      pfam00153
      Location:89 → 176
      Mito_carr; Mitochondrial carrier protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q499U1.2 GenPept UniProtKB/Swiss-Prot:Q499U1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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