HSU1 cystathionine gamma-synthase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: HSU1
Official Full Name: cystathionine gamma-synthase
Primary source: SGD:S000003981
Locus tag: YLL058W
See related: AllianceGenome:SGD:S000003981; FungiDB:YLL058W; VEuPathDB:YLL058W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables O-acetylhomoserine sulfhydrylase activity. Involved in sulfur compound metabolic process. Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See HSU1 in Genome Data Viewer

Location:: chromosome: XII

Exon count:: 1

Sequence:: Chromosome: XII; NC_001144.5 (23569..25296)

Chromosome XII - NC_001144.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Inorganic sulfur fixation via a new homocysteine synthase allows yeast cells to cooperatively compensate for methionine auxotrophy.
Title: Inorganic sulfur fixation via a new homocysteine synthase allows yeast cells to cooperatively compensate for methionine auxotrophy.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables O-acetylhomoserine sulfhydrylase activity	IDA Inferred from Direct Assay more info	PubMed
enables O-acetylhomoserine sulfhydrylase activity	IEA Inferred from Electronic Annotation more info
enables cystathionine gamma-synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cystathionine gamma-synthase activity	IEA Inferred from Electronic Annotation more info
enables cysteine synthase activity	IEA Inferred from Electronic Annotation more info
enables pyridoxal phosphate binding	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in 'de novo' L-methionine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in cysteine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in methionine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in sulfur compound metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transsulfuration	IBA Inferred from Biological aspect of Ancestor more info
involved_in transsulfuration	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cystathionine gamma-synthase

NP_013042.1

EC 2.5.1.47

EC 2.5.1.49

Inefficient homocysteine synthase; catalyzes de novo homocysteine biosynthesis; capable of catalyzing same reaction as Met17p; affects S-methylmethionine metabolism; similar to Str2p, which is a cystathionine gamma-synthase important in sulfur metabolism; HSU1 is not an essential gene

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001144.5 Reference assembly

Range

23569..25296

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001181878.1 → NP_013042.1 TPA: cystathionine gamma-synthase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_013042.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VXV0, Q12198

UniProtKB/TrEMBL

C7GND7, G2WIE2

Conserved Domains (1) summary

COG0626
Location:117 → 568

MetC; Cystathionine beta-lyase/cystathionine gamma-synthase [Amino acid transport and metabolism]