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    NFT1 putative multidrug transporter NFT1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853978, updated on 9-Dec-2024

    Summary

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    Official Symbol
    NFT1
    Official Full Name
    putative multidrug transporter NFT1
    Primary source
    SGD:S000001811
    Locus tag
    YKR103W
    See related
    AllianceGenome:SGD:S000001811; FungiDB:YKR103W; VEuPathDB:YKR103W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable ATPase-coupled transmembrane transporter activity. Involved in macroautophagy. Located in fungal-type vacuole membrane. Human ortholog(s) of this gene implicated in several diseases, including alcoholic pancreatitis; allergic bronchopulmonary aspergillosis; bronchial disease (multiple); congenital bilateral absence of vas deferens (multiple); and lung disease (multiple). Orthologous to human ABCC10 (ATP binding cassette subfamily C member 10) and CFTR (CF transmembrane conductance regulator). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See NFT1 in Genome Data Viewer
    Location:
    chromosome: XI
    Exon count:
    1
    Sequence:
    Chromosome: XI; NC_001143.9 (653080..656736)

    Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene Sir1p Neighboring gene Flo10p Neighboring gene uncharacterized protein Neighboring gene basic amino acid transporter

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001143.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A region within a lumenal loop of Saccharomyces cerevisiae Ycf1p directs proteolytic processing and substrate specificity. Mason DL, et al. Eukaryot Cell, 2003 Jun. PMID 12796304, Free PMC Article
    2. An In Vitro Assembly System Identifies Roles for RNA Nucleation and ATP in Yeast Stress Granule Formation. Begovich K, et al. Mol Cell, 2020 Sep 17. PMID 32780990
    3. The yeast ATP-binding cassette (ABC) transporter Ycf1p enhances the recruitment of the soluble SNARE Vam7p to vacuoles for efficient membrane fusion. Sasser TL, et al. J Biol Chem, 2013 Jun 21. PMID 23658021, Free PMC Article
    4. Control of Plasma Membrane Permeability by ABC Transporters. Khakhina S, et al. Eukaryot Cell, 2015 May. PMID 25724885, Free PMC Article
    5. The SUN protein Mps3 is required for spindle pole body insertion into the nuclear membrane and nuclear envelope homeostasis. Friederichs JM, et al. PLoS Genet, 2011 Nov. PMID 22125491, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ABC-type transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase-coupled transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in macroautophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in fungal-type vacuole membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in fungal-type vacuole membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    putative multidrug transporter NFT1
    NP_013029.3
    • Putative transporter of the MRP subfamily; adjacent ORFs YKR103W and YKR104W are merged in different strain backgrounds; MRP stands for multidrug resistance-associated protein

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001143.9 Reference assembly

      Range
      653080..656736
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179893.3 → NP_013029.3  TPA: putative multidrug transporter NFT1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013029.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VXG4, P0CE68, P36028, P36171, Q53ZY4, Q6Q5L3
      UniProtKB/TrEMBL
      N1NZL8
      Conserved Domains (1) summary
      TIGR00957
      Location:252 → 1218
      MRP_assoc_pro; multi drug resistance-associated protein (MRP)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P0CE68.1

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