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    IKI1 Elongator subunit IKI1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856594, updated on 9-Dec-2024

    Summary

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    Official Symbol
    IKI1
    Official Full Name
    Elongator subunit IKI1
    Primary source
    SGD:S000001230
    Locus tag
    YHR187W
    See related
    AllianceGenome:SGD:S000001230; FungiDB:YHR187W; VEuPathDB:YHR187W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    ELP5; HAP2; TOT5
    Summary
    Contributes to ATP hydrolysis activity and tRNA binding activity. Involved in tRNA modification. Located in nucleus and peroxisome. Part of elongator holoenzyme complex. Orthologous to human ELP5 (elongator acetyltransferase complex subunit 5). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See IKI1 in Genome Data Viewer
    Location:
    chromosome: VIII
    Exon count:
    1
    Sequence:
    Chromosome: VIII; NC_001140.6 (480990..481919)

    Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene tRNA-Val Neighboring gene ubiquitin-binding TORC1 subunit KOG1 Neighboring gene GPI-anchor transamidase subunit GPI16 Neighboring gene aminoacyl-tRNA hydrolase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001140.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Isolation and genetic characterization of pGKL killer-insensitive mutants (iki) from Saccharomyces cerevisiae. Kishida M, et al. Biosci Biotechnol Biochem, 1996 May. PMID 8704309
    2. Characterization of IKI1 and IKI3 genes conferring pGKL killer sensitivity on Saccharomyces cerevisiae. Yajima H, et al. Biosci Biotechnol Biochem, 1997 Apr. PMID 9145530
    3. Yeast HAP2 and HAP3: transcriptional activators in a heteromeric complex. Hahn S, et al. Science, 1988 Apr 15. PMID 2832951
    4. Novel domains and orthologues of eukaryotic transcription elongation factors. Ponting CP. Nucleic Acids Res, 2002 Sep 1. PMID 12202748, Free PMC Article
    5. Cloning of yeast HAP5: a novel subunit of a heterotrimeric complex required for CCAAT binding. McNabb DS, et al. Genes Dev, 1995 Jan 1. PMID 7828851

    See all (67) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    contributes_to ATP hydrolysis activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to ATP hydrolysis activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    contributes_to tRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to tRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in tRNA modification IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA modification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA wobble uridine modification IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of elongator holoenzyme complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of elongator holoenzyme complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of elongator holoenzyme complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in peroxisome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Elongator subunit IKI1
    NP_012057.3
    • Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; iki1 mutations confer resistance to the K. lactis toxin zymocin; localizes to cytosol, nucleus and peroxisomes

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001140.6 Reference assembly

      Range
      480990..481919
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179318.3 → NP_012057.3  TPA: Elongator subunit IKI1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012057.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DLD5, P38874
      UniProtKB/TrEMBL
      A6ZT93, B3LSU8, B5VKB6, C7GRK9, C8Z9Y6
      Conserved Domains (1) summary
      pfam10483
      Location:11 → 290
      Elong_Iki1; Elongator subunit Iki1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38874.1

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