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    VPS73 putative sugar transporter [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852774, updated on 9-Dec-2024

    Summary

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    Official Symbol
    VPS73
    Official Full Name
    putative sugar transporter
    Primary source
    SGD:S000003072
    Locus tag
    YGL104C
    See related
    AllianceGenome:SGD:S000003072; FungiDB:YGL104C; VEuPathDB:YGL104C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable hexose transmembrane transporter activity. Involved in protein targeting to vacuole. Located in fungal-type vacuole membrane and mitochondrion. Human ortholog(s) of this gene implicated in epilepsy (multiple); glucose transporter type 1 deficiency syndrome (multiple); myelomeningocele; obesity; and type 2 diabetes mellitus. Orthologous to several human genes including SLC2A4 (solute carrier family 2 member 4) and SLC2A9 (solute carrier family 2 member 9). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See VPS73 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (308713..310173, complement)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene Mlc1p Neighboring gene Arc1p Neighboring gene ribosomal 60S subunit protein L28 Neighboring gene 5'-deoxynucleotidase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A phylogenetic analysis of the sugar porters in hemiascomycetous yeasts. Palma M, et al. J Mol Microbiol Biotechnol, 2007. PMID 17587872
    2. RNAi expression tuning, microfluidic screening, and genome recombineering for improved protein production in Saccharomyces cerevisiae. Wang G, et al. Proc Natl Acad Sci U S A, 2019 May 7. PMID 31000602, Free PMC Article
    3. Prevacuolar compartment morphology in vps mutants of Saccharomyces cerevisiae. Hedman JM, et al. Cell Biol Int, 2007 Oct. PMID 17543551
    4. The Saccharomyces cerevisiae Ptc1 protein phosphatase attenuates G2-M cell cycle blockage caused by activation of the cell wall integrity pathway. Tatjer L, et al. Mol Microbiol, 2016 Aug. PMID 27169355
    5. Genomic screen for vacuolar protein sorting genes in Saccharomyces cerevisiae. Bonangelino CJ, et al. Mol Biol Cell, 2002 Jul. PMID 12134085, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables hexose transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in hexose transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monosaccharide transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein targeting to vacuole HMP PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in fungal-type vacuole membrane HDA PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    putative sugar transporter
    NP_011411.3
    • Mitochondrial protein; mutation affects vacuolar protein sorting; putative transporter; member of the sugar porter family; VPS73 has a paralog, YBR241C, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      308713..310173 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180969.3 → NP_011411.3  TPA: putative sugar transporter [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011411.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VU42, P53142
      UniProtKB/TrEMBL
      A6ZU77, B3LHG8, C7GM21, C8Z8E4, N1P347
      Conserved Domains (1) summary
      cd17357
      Location:31 → 484
      MFS_GLUT_Class1_2_like; Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53142.1

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