TFB3 TFIIH/NER complex subunit TFB3 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: TFB3
Official Full Name: TFIIH/NER complex subunit TFB3
Primary source: SGD:S000002868
Locus tag: YDR460W
See related: AllianceGenome:SGD:S000002868; FungiDB:YDR460W; VEuPathDB:YDR460W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: RIG2
Summary: Predicted to enable cyclin-dependent protein serine/threonine kinase activator activity and zinc ion binding activity. Predicted to contribute to RNA polymerase II complex binding activity. Involved in nucleotide-excision repair and transcription by RNA polymerase II. Part of transcription factor TFIIK complex. Orthologous to human MNAT1 (MNAT1 component of CDK activating kinase). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See TFB3 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 1

Sequence:: Chromosome: IV; NC_001136.10 (1383811..1384776)

Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Transcription start site scanning requires the fungi-specific hydrophobic loop of Tfb3.
Title: Transcription start site scanning requires the fungi-specific hydrophobic loop of Tfb3.
Tfb3, a subunit of the transcription factor TFIIH, controls activation of a subset of cullins.
Title: The TFIIH subunit Tfb3 regulates cullin neddylation.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
contributes_to RNA polymerase II complex binding	IC Inferred by Curator more info	PubMed
enables cyclin-dependent protein serine/threonine kinase activator activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	RCA inferred from Reviewed Computational Analysis more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA repair	IBA Inferred from Biological aspect of Ancestor more info
involved_in nucleotide-excision repair	IEA Inferred from Electronic Annotation more info
involved_in nucleotide-excision repair	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of transcription factor TFIIH holo complex	IBA Inferred from Biological aspect of Ancestor more info
part_of transcription factor TFIIH holo complex	IDA Inferred from Direct Assay more info	PubMed
part_of transcription factor TFIIH holo complex	IEA Inferred from Electronic Annotation more info
part_of transcription factor TFIIK complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: TFIIH/NER complex subunit TFB3

NP_010748.3

Subunit of TFIIH and nucleotide excision repair factor 3 complexes; involved in transcription initiation, required for nucleotide excision repair; ring finger protein similar to mammalian CAK and TFIIH subunit

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001136.10 Reference assembly

Range

1383811..1384776

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001180768.3 → NP_010748.3 TPA: TFIIH/NER complex subunit TFB3 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_010748.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VT84, P89104, Q03290

UniProtKB/TrEMBL

A6ZZ50, B3LFK5, B5VGZ2, C7GKQ1, C8Z618, G2WBJ0, N1P8Z0

Conserved Domains (1) summary

COG5220
Location:2 → 321

TFB3; Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, subunit TFB3 [Cell division and chromosome partitioning / Transcription / DNA replication, recombination, and repair]